Chemical and Enzymatic Synthesis of Beta Lactam Antibiotics PDF Download
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Author: C. J. Schofield
Publisher:
ISBN:
Category : Beta lactam antibiotics
Languages : en
Pages : 0
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Author: C. J. Schofield
Publisher:
ISBN:
Category : Beta lactam antibiotics
Languages : en
Pages : 0
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Author: C. J. Schofield
Publisher:
ISBN:
Category : Beta lactam antibiotics
Languages : en
Pages : 478
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Author: Alle Bruggink
Publisher: Springer Science & Business Media
ISBN: 9401008507
Category : Science
Languages : en
Pages : 328
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Book Description
Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Author: M.I. Page
Publisher: Springer Science & Business Media
ISBN: 9401129282
Category : Science
Languages : en
Pages : 368
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Book Description
It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH )=r)
![Chemistry and Biology of [beta]-lactam Antibiotics PDF](https://books.google.com/books/content/images/frontcover/_LBFAQAAMAAJ?fife=w80-h100)
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 464
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![Chemical and Enzymatic Synthesis of [beta]-lactams PDF](https://books.google.com/books/content/images/frontcover/un_PoAEACAAJ?fife=w80-h100)
Author: Jane Virden
Publisher:
ISBN:
Category : Beta lactam antibiotics
Languages : en
Pages : 348
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Author: Andria Lynn Deaguero
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages :
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Book Description
Semi-synthetic ©3¡2©60́9©30́Œ©2℗ư©3¡2â2́Ơš©30́(©2℗ø-lactam antibiotics are the most prescribed class of antibiotics in the world. Chemical coupling of a ©3¡2©60́9©30́Œ©2℗ư©3¡2â2́Ơš©30́(©2℗ø-lactam moiety with an acyl side chain has dominated the industrial production of semi-synthetic ©3¡2©60́9©30́Œ©2℗ư©3¡2â2́Ơš©30́(©2℗ø-lactam antibiotics since their discovery in the early 1960s. Enzymatic coupling of a ©3¡2©60́9©30́Œ©2℗ư©3¡2â2́Ơš©30́(©2℗ø-lactam moiety with an acyl side chain can be accomplished in a process that is much more environmentally benign but also results in a much lower yield. The goal of the research presented in this dissertation is to improve the enzymatic synthesis of ©3¡2©60́9©30́Œ©2℗ư©3¡2â2́Ơš©30́(©2℗ø-lactam antibiotics via reaction engineering, medium engineering and data-drive protein engineering. :Reaction engineering was employed to demonstrate that the hydrolysis of penicillin G to produce the ©3¡2©60́9©30́Œ©2℗ư©3¡2â2́Ơš©30́(©2℗ø-lactam nucleus 6-aminopenicillanic acid (6-APA), and the synthesis of ampicillin from 6-APA and (R)-phenylglycine methyl ester ((R)-PGME), can be combined in a cascade conversion. In this work, penicillin G acylase (PGA) was utilized to catalyze the hydrolysis step, and PGA and ©3¡2©60́9©30́Œ©2℗ư©3¡2â2́Ơš©30́(©2±-amino ester hydrolase (AEH) were both studied to catalyze the synthesis step. Two different reaction configurations and various relative enzyme loadings were studied. Both configurations present a promising alternative to the current two-pot set-up which requires intermittent isolation of the intermediate, 6-APA.
Author: Luigi De Martin
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Bimal K. Banik
Publisher: Springer
ISBN: 3319556215
Category : Science
Languages : en
Pages : 423
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Book Description
This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.
Author: Maghar S. Manhas
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 264
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