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Author: Ronald P. Rubin
Publisher: Springer Science & Business Media
ISBN: 1468442171
Category : Science
Languages : en
Pages : 284
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Book Description
Since the publication of my previous monograph in 1974, important progress has been made in the broad area of calcium research, partic ularly as it pertains to secretory phenomena. The significant advance in methodology, while widening the scope of our knowledge, has caused research in this particular area to become more and more specialized. It has, therefore, become increasingly difficult for researchers to consider and evaluate work outside their own areas of specialization and to com prehend the field from a broad perspective. While many valuable re views on the importance of calcium in cellular function are being pro duced, they have not attempted to pull together all of the existing knowledge into a more general narrative. This volume brings together experimental data and theories from diverse sources, and attempts to synthesize into a broad conceptual framework the massive amount of specialized information that presently exists in the general area of cal cium metabolism and the secretory process. It is impossible in a book of this length to discuss specific references in detail and still maintain readability, so generalizations must be made.
Author: Ronald P. Rubin
Publisher: Springer Science & Business Media
ISBN: 1468442171
Category : Science
Languages : en
Pages : 284
Get Book
Book Description
Since the publication of my previous monograph in 1974, important progress has been made in the broad area of calcium research, partic ularly as it pertains to secretory phenomena. The significant advance in methodology, while widening the scope of our knowledge, has caused research in this particular area to become more and more specialized. It has, therefore, become increasingly difficult for researchers to consider and evaluate work outside their own areas of specialization and to com prehend the field from a broad perspective. While many valuable re views on the importance of calcium in cellular function are being pro duced, they have not attempted to pull together all of the existing knowledge into a more general narrative. This volume brings together experimental data and theories from diverse sources, and attempts to synthesize into a broad conceptual framework the massive amount of specialized information that presently exists in the general area of cal cium metabolism and the secretory process. It is impossible in a book of this length to discuss specific references in detail and still maintain readability, so generalizations must be made.
Author: Ernesto Carafoli
Publisher: Oxford University Press, USA
ISBN: 9780195094213
Category : Calcium
Languages : en
Pages : 664
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Book Description
Encompassing all aspects of calcium signalling, from methods of measuring calcium in cells to the molecular mechanisms for decoding its information, this comprehensive book balances historical aspects and state of the art developments.
Author: Juliusz Ashot Kozak
Publisher: CRC Press
ISBN: 149875273X
Category : Science
Languages : en
Pages : 343
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Book Description
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309
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Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author: Wai Yiu Cheung
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 536
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Book Description
Author:
Publisher: Academic Press
ISBN: 0124079385
Category : Science
Languages : en
Pages : 307
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Book Description
Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Author: Brunde Broady
Publisher: Simon and Schuster
ISBN: 1510763929
Category : Medical
Languages : en
Pages : 264
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Book Description
Did you know that one single enzyme impacts your odds of contracting most deadly diseases and health conditions? An enormous body of reputable research into this enzyme has been isolated, ignored, and misunderstood by medical experts. The importance of this enzyme simply cannot be overstated. The Calcium Connection: The Little-Known Enzyme at the Root of Your Cellular Health delivers a clear explanation of this enzyme’s function and outlines the steps you can take to gain optimal enzyme health. The accessible, information-packed format teaches you all about Calcium ATPase: how it works, what happens when it goes awry, and easy, practical methods to bring it back into balance and protect it—and your overall health. Whether you’re a health enthusiast, environmentalist, parent, or just want to be better informed, this book will help you boost your health now and into the future. Brunde Broady recounts her tireless quest to find a cure for her son Knute’s compromised health since being whisked away and kept in ICU after birth. The medical establishment could only help manage his condition, but not diagnose or cure him. Doing her own research and documenting everything Knute ate and his reactions to certain foods, she came across two ubiquitous food additives. Diving deeper, she learned how Calcium ATPase, a fundamental regulator of intercellular calcium, is negatively impacted, not only by these additives, but by a torrent of other inhibitors. Knute’s health is a testament to Brunde’s discoveries, and The Calcium Connection gives readers a front-row seat to understanding how to maintain optimized cellular health.
Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258
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Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author: James G. McCormack
Publisher: IRL Press
ISBN:
Category : Medical
Languages : en
Pages : 452
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Book Description
Calcium plays a key role in signal transduction - hormones and other extracellular agents bring about many of the changes in intracellular calcium concentrations. This book provides a comprehensive description of current techniques for measuring intracellular calcium ion concentrations.
Author:
Publisher: Academic Press
ISBN: 0080859380
Category : Science
Languages : en
Pages : 393
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Book Description
A Practical Guide to the Study of Calcium in Living Cells describes popular techniques along with helpful do's and don't's and computer programs. The volume enables investigators to evaluate confocal images, use the latest dyes, and design Calcium buffers appropriate to their research needs. This book is designed for laboratory use by graduate students, technicians, and researchers in many disciplines, ranging from molecular to cellular levels of investigation. Describes techniques for detection of [Ca2+]I: Ca2+ - sensitive microelectrodes Fluorescent dyes Luminescent proteins Includes techniques for perturbing intracellular Ca2+ Covers detailed methodology plus problems and pitfalls of each technique Contains a practical guide to preparing Ca2+ buffers with an easy-to-use computer program Color plates illustrate techniques such as Confocal ratio-imaging Use of aequorin
