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Author: Douglas W Houston
Publisher: Academic Press
ISBN: 0128125918
Category : Science
Languages : en
Pages : 238
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Book Description
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. - Provides basic science understanding of cell polarity disease and development - Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer - Includes historical context of cell polarity research for potential future breakthroughs
Author: Douglas W Houston
Publisher: Academic Press
ISBN: 0128125918
Category : Science
Languages : en
Pages : 238
Get Book Here
Book Description
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. - Provides basic science understanding of cell polarity disease and development - Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer - Includes historical context of cell polarity research for potential future breakthroughs
Author: Keith E. Mostov
Publisher: Perspectives Cshl
ISBN: 9781621821458
Category : Science
Languages : en
Pages : 0
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Book Description
Most animal cells are polarized, with structurally and functionally distinct regions. This polarization facilitates processes such as differentiation and morphogenesis, directional cell migration, nerve impulse transmission, and transport of molecules across tissues. The dysregulation of these processes can lead to developmental disorders and is a feature of many cancers. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of the molecular mechanisms involved in establishing and maintaining cell polarity, as well as their relevance for human disorders. Contributors discuss how cells coordinate signaling pathways, membrane trafficking, and cytoskeletal remodeling to ensure proper spatial arrangement of cellular components. Processes such as transcytosis, exocyst-mediated vesicle trafficking, and endosomal sorting are covered in detail. Throughout, the focus is on epithelial cells and how polarity mechanisms facilitate the development of their apical and basolateral surfaces, tube formation (e.g., in blood vessel development), exchange of waste and nutrients, and the generation and maintenance of specialized structures at the cell surface (e.g., cilia). The authors also describe the polarity mechanisms involved in collective cell migration, a phenomenon seen during morphogenesis and cancer metastasis. This volume will thus be essential reading for all cell and developmental biologists, as well as those interested in how cell polarity processes impact human health and disease.
Author: Jamie A. Davies
Publisher: Academic Press
ISBN: 0124157572
Category : Science
Languages : en
Pages : 417
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Book Description
Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, Mechanisms of Morphogenesis, second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. By combining hard data with computer modeling, Mechanisms of Morphogenesis, second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future - Includes over 200 four-color figures - Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries - Covers experimental techniques as a guide to the reader - Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems
Author: K. Lindsey
Publisher: John Wiley & Sons
ISBN: 9780849323447
Category : Science
Languages : en
Pages : 368
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Book Description
The establishment of polarity is a fundamental feature in eukaryotic development. Polarity in Plants provides an account of current research into the mechanisms by which polarity is generated at the level of the cell, organ and organism in plants, drawing especially on recent work with model organisms. The emphasis is on the use of the techniques of molecular genetics to dissect molecular mechanisms. This is the first volume to bring together the diverse aspects of polarity in plant development.
Author: Vance Tartar
Publisher: Elsevier
ISBN: 148316456X
Category : Science
Languages : en
Pages : 426
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Book Description
The Biology of Stentor summarizes all that has been learned about the biology of a certain group of ciliate protozoa: the stentors. Topics covered range from form and function in Stentor to behavior, fine structure, growth and division, and reorganization. Regeneration is also discussed, along with polarity, metabolism, genetics, and primordium development. This volume is comprised of 20 chapters and begins with a characterization of Stentor, with emphasis on its particular advantages in addressing general problems of biology. The reader is then introduced to form and function in Stentor, particularly S. coeruleus. The following chapters focus on the behavior (food selection, swimming, response to light, etc.) of stentors and the fine points of structure in terms of which this behavior is to be explained and which demonstrate the highly complex and precise achievements of morphogenesis. The remaining chapters explore growth and division in Stentor as well as the course of reorganization and regeneration; development of the oral primordium and how it is activated and inhibited; rate of regeneration in relation to the polar axis; fusion masses of whole stentors; and reconstitution in disarranged stentors. Various species of Stentor are also described, together with the techniques used to study them. The final chapter deals with hypotheses concerning the morphogenesis of ciliates. This book will be of interest to students and practitioners of biology and physiology.
Author: Vincenzo Capasso
Publisher: Springer Science & Business Media
ISBN: 3642201636
Category : Mathematics
Languages : en
Pages : 283
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Book Description
Pattern Formation in Morphogenesis is a rich source of interesting and challenging mathematical problems. The volume aims at showing how a combination of new discoveries in developmental biology and associated modelling and computational techniques has stimulated or may stimulate relevant advances in the field. Finally it aims at facilitating the process of unfolding a mutual recognition between Biologists and Mathematicians of their complementary skills, to the point where the resulting synergy generates new and novel discoveries. It offers an interdisciplinary interaction space between biologists from embryology, genetics and molecular biology who present their own work in the perspective of the advancement of their specific fields, and mathematicians who propose solutions based on the knowledge grasped from biologists.
Author:
Publisher: Academic Press
ISBN: 0123850452
Category : Science
Languages : en
Pages : 337
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Book Description
Vision is our primary sensory modality, and we are naturally curious as to how the visual system assembles. The visual system is in many ways remarkably simple, a repeating assemblage of neurons and support cells that parse the visual field through precision and redundancy. Through this simplicity the eye has often led the way in our exploration of how an organ is assembled. Eye development has therefore long been a favorite for exploring mechanisms of cell fate choice, patterning and cell signaling.This volume, which is part of the Current Topics in Developmental Biology series, highlights the exceptional advances over the past 20 years. Chapters emphasize our knowledge of transcription factors and how these generate networks to direct the eye field and associated structures. Topics such as cell fate specification are also explored, along with the potential of Drosophila as a model for lens formation and the progress made in using the Drosophila eye to examine planar cell polarity. - Contributions from researchers who are active in identifying new paradigms to explore - Review of our current state of knowledge - Chapters written by authors with a new generation approach that takes a more systems approach to identifying factors and better defines cell subtypes
Author: James Spudich
Publisher:
ISBN: 9780824331733
Category : Actin
Languages : en
Pages : 0
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Book Description
Author: Alexander Anderson
Publisher: Springer Science & Business Media
ISBN: 376438123X
Category : Mathematics
Languages : en
Pages : 346
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Book Description
Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.
Author:
Publisher: Academic Press
ISBN: 0128094575
Category : Science
Languages : en
Pages : 238
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Book Description
Cell Polarity and Morphogenesis, the latest volume in the Methods in Cell Biology series, looks at cell polarity and morphogenesis. Edited by leaders in the field, this volume provides proven, state-of-art techniques, along with relevant historical background and theory, to aid researchers in efficient design and effective implementation of experimental methodologies. - Covers sections on cell polarity, morphogenesis, and emerging studies - Written by experts in the field - Includes cutting-edge materials
