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Author: Sally A. Moody
Publisher: Elsevier
ISBN: 0080528783
Category : Science
Languages : en
Pages : 661
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Book Description
Cell Lineage and Fate Determination provides a comprehensive view of the mechanisms regulating cell lineage and fate determination in an effort to understand how the fertilized egg is transformed into a complex of specialized tissues. It presents basic information on eight different animal models and recent developmental biological research done in each model. The book provides a focused forum presenting key information for researchers studying various aspects of developmental and cellular biology. Extensive use of tables and black-and-white and color figures helps illustrate each model. The book concludes by discussing future goals for bringing cellular, molecular, and genetic research to clinical applications and tissue replacement therapies. Key Features* Presents eight different animal models* Provides a focused forum on cell fate determination that provides comprehensive and key information for researchers* Illustrates the transitional relationship between researchers and clinicians* Includes the extensive use of tables and color figures
Author: Sally A. Moody
Publisher: Elsevier
ISBN: 0080528783
Category : Science
Languages : en
Pages : 661
Get Book Here
Book Description
Cell Lineage and Fate Determination provides a comprehensive view of the mechanisms regulating cell lineage and fate determination in an effort to understand how the fertilized egg is transformed into a complex of specialized tissues. It presents basic information on eight different animal models and recent developmental biological research done in each model. The book provides a focused forum presenting key information for researchers studying various aspects of developmental and cellular biology. Extensive use of tables and black-and-white and color figures helps illustrate each model. The book concludes by discussing future goals for bringing cellular, molecular, and genetic research to clinical applications and tissue replacement therapies. Key Features* Presents eight different animal models* Provides a focused forum on cell fate determination that provides comprehensive and key information for researchers* Illustrates the transitional relationship between researchers and clinicians* Includes the extensive use of tables and color figures
Author: August Weismann
Publisher:
ISBN:
Category : Genetics
Languages : en
Pages : 524
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Book Description
Author: Paul Wassarman
Publisher: Academic Press
ISBN: 0128016167
Category : Science
Languages : en
Pages : 916
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Book Description
In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come. Covers the area of developmental processes for a variety of model organisms International board of authors Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman
Author: Chin-Hsing Annie Lin
Publisher: Frontiers Media SA
ISBN: 2889198529
Category : Genetics
Languages : en
Pages : 104
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Book Description
The fundamental question of how an undifferentiated progenitor cell adopts a more specialized cell fate that then contributes to the development of specialized tissues, organs, organ systems and ultimately a unique individual of a given species has intrigued cell and developmental biologists for many years. Advances in molecular and cell biology have enabled investigators to identify genetic and epigenetic factors that contribute to these processes with increasing detail and also to define the various molecular characteristics of each cell fate with greater precision. Understanding these processes have also provided greater insights into disorders in which the normal mechanisms of cell fate determination are altered, such as in cancer and inherited malformations. With these advances have come techniques that facilitate the manipulation of cell fate, which have the potential to revolutionize the field of medicine by facilitating the repair and/or regeneration of diseased organs. Given the rapid advances that are occurring in the field, the articles in this eBook are both relevant and timely. These articles originally appeared online as part of the Research Topic “Cell Fate” overseen by my colleagues Dr. Lin, Dr. Buttitta, Dr. Maves, Dr. Dilworth, Dr. Paladini and myself and have been viewed extensively. Because of their popularity, they are now made available as an eBook, in a more easily downloadable form. Michael T. Chin
Author: Thomas Hunt Morgan
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 794
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Book Description
Experimentelle Embryologie.
Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258
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Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author:
Publisher: Elsevier
ISBN: 008048915X
Category : Science
Languages : en
Pages : 623
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Book Description
International Review of Cytology presents current advances and comprehensive reviews in cell biology, both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. This volume brings together current information on the localization and roles of RNAs in cell-lineage determination and subsequent patterning in embryonic development. Guest co-editor Lawrence Etkin is one of the leading researchers in molecular genetics of Xenopus. Key Features * A number of important concepts are discussed, including: * How polarity is established during oogenesis * How germ cell determinants become organized in the establishment of the germ cell lineage * Different strategies used by organisms to establish the germ cell lineage * Similarities and differences between the mechanisms used in embryonic patterning * The mechanisms and machinery by which molecules such as RNA become asymmetrically segregated * The use of similar signaling pathways in patterning of the dorsal-ventral and right-left asymmetries, embryonic germ layers, limb, and nervous system * The link between fundamental biological processes such as RNA translation and localization in the regulation of axis specification
Author: William Barry Wood
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 694
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Book Description
Author: Nicole Le Douarin
Publisher: North-Holland
ISBN:
Category : Science
Languages : en
Pages : 404
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Book Description
Author: Albert C. Huang
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Cell fate determination, the process of transforming a unicellular embryonic cell into lineage-restricted specific tissues of a multicellular organism, is fundamental to the process of development. Following the division of a single zygote, how can seemingly similar neighboring cells ultimately differentiate into disparate cell fates, and maintain their differences? An understanding of this complex and intricate process is important for stem cell-based therapies and treatment of cancer. To provide the necessary conceptual background, we review two complementary perspectives that aid our understanding of the differentiation process -- a systems dynamics level view and a molecular mechanism level view. We introduce the experimental systems, the diverse types of data collected for this work, and computational methods to integrate them to arrive at a coherent model. From a systems dynamics perspective, cell fates can be thought of as attractors in the high dimensional gene regulatory networks. With this view, we designed experiments that identified a class of genes that are "divergent" in their expression during the differentiation process. These genes are associated with neutrophil differentiation and cell cycle progression. Further promoter-based transcription factor binding site analyses reveal enrichment of factors functionally linked to cancer progression and neutrophil differentiation, suggesting a systems dynamics view has the potential to elucidate mechanistic level details. From a molecular mechanistic perspective, we investigate how T-bet, a Th1 lineage defining transcription factor, functionally regulates its target genes. We experimentally determine genome-wide binding locations of T-bet and target genes that it regulates. We find distinct genomic signal patterns for genes that are differentially regulated compared to those that are not. We find that the chromatin-modifying and N-terminal domains of the T-bet protein are necessary for the regulation of T-bet targets. Further, T-bet targets are also differentially regulated in other T helper subtypes. Both perspectives offer unique insights into the differentiation process. Future direction would include methods to combine both perspectives by modeling mechanistic details while keeping track of the larger dynamic "emergent" attractor properties of the network.
