Author: Helmut Knolle
Publisher: Springer Science & Business Media
ISBN: 3642456510
Category : Medical
Languages : en
Pages : 170
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Book Description
During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977).
Author: Stanley Zietz
Publisher:
ISBN:
Category :
Languages : en
Pages : 442
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Book Description
Author: M Eisen
Publisher:
ISBN: 9783642931277
Category :
Languages : en
Pages : 452
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Book Description
Author: Kang Geun Shin
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 312
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Book Description
Author: T. E. Wheldon
Publisher: CRC Press
ISBN:
Category : Art
Languages : en
Pages : 272
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Book Description
Cancer research deals with all aspects of malignant transformation, tumour growth and the effects of treatment. Mathematical models enable quantitative representations of the changes affecting cell state and cell number. This book provides a review of the scope of mathematical modelling in cancer research, bringing together for the first time a group of related mathematical topics including multistage carcinogenesis, tumour growth kinetics, growth control, radiotherapy, chemotherapy and biological targeting in cancer treatment. Physicists and mathematicians interested in medical research, biomathematicians, biostatisticians, radiation and medical oncologists and experimental and theoretical biologists will welcome this critical review of mathematical modelling in cancer research. This book will also be of interest to clinicians, basic cancer scientists and physicists working in radiotherapy departments, and to postgraduate students on courses in oncology and subjects.
Author: Robert C. Jackson
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 472
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Book Description
Describes the principles of cancer chemotherapy quantitatively, using computer modelling. The book includes a computer program on disk to allow the user to model tumour biology and drug effects. This allows a trial and error approach to understanding the principles of chemotherapy.
Author: N. M. Emanuel
Publisher: Elsevier
ISBN: 1483145182
Category : Medical
Languages : en
Pages : 349
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Book Description
Kinetics of Experimental Tumour Processes focuses on the principles of the kinetics of experimental malignant growth. This book also looks into the molecular mechanisms of chemotherapy and certain problems of carcinogenesis and biochemistry. Organized into eight chapters, this monograph first describes the kinetic curve for tumor growth and the experimental data on tumor growth from the USSR and elsewhere. Subsequent chapters deal with kinetic analysis of the results obtained by various treatments of tumors; pharmacokinetic methods of major regularities connected with general problems of cancer chemotherapy; molecular mechanisms of chemotherapy; and the role of free radicals in the mechanisms of carcinogenesis and tumor growth. The last two chapters detail the kinetic analysis of biochemical shifts occurring in tumor tissues and the disturbance of structure and biosynthesis of informational macromolecules occurring in tumor growth. This book will help in the mutual efforts among researchers for the solution of the most important current problems in oncology.
Author: Richard Alan Fundakowski
Publisher:
ISBN:
Category :
Languages : en
Pages : 502
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Book Description
Author: W. Y. Tan
Publisher: World Scientific
ISBN: 9812779485
Category : Political Science
Languages : en
Pages : 592
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Book Description
Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer, and stochastic models of metastasis. The book also provides some important applications of cancer models to the assessment of cancer risk associated with various hazardous environmental agents, to cancer screening by MRI, and to drug resistance in cancer chemotherapy. An updated statistical design and analysis of xenograft experiments as well as a statistical analysis of cancer occult clinical data are also provided.The book will serve as a useful source of reference for researchers in biomathematics, biostatistics and bioinformatics; for clinical investigators and medical doctors employing quantitative methods to develop procedures for cancer diagnosis, prevention, control and treatment; and for graduate students.
Author:
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 216
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Book Description
