Catalytic Enantioselective Transformations with Chiral Cyclopentadienyl Ruthenium(II) Complexes PDF Download
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Author: Sung Hwan Park
Publisher:
ISBN:
Category :
Languages : en
Pages : 280
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Book Description
Mots-clés de l'auteur: ruthenium ; cyclopentadienyl ligand ; asymmetric catalysis.
Author: Sung Hwan Park
Publisher:
ISBN:
Category :
Languages : en
Pages : 280
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Book Description
Mots-clés de l'auteur: ruthenium ; cyclopentadienyl ligand ; asymmetric catalysis.
Author: David Kossler
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Mots-clés de l'auteur: ruthenium ; cyclopentadienyl ligand ; asymmetric catalysis ; cycloisomerization.
Author: Helene Pellissier
Publisher: World Scientific
ISBN: 1783268964
Category : Science
Languages : en
Pages : 278
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Book Description
Chiral titanium complexes are low-cost, low-toxicity and high-efficiency catalysts. Impressive progress on enantioselective titanium-catalysed transformations has been achieved in the past seven years, with exciting new discoveries ranging from basic reactions to novel methodologies. Despite this, the field has not been substantially reviewed since 2008.This book contains up to date research and covers all types of enantioselective transformations using chiral titanium catalysts. It illustrates the economic, health, and environmental benefits of chiral titanium catalysts, showing the types of highly enantioselective reactions that they are able to induce are unlimited.Work presented here is aimed at researchers in organic and catalytic chemistry, and has been carefully curated to encourage future research possibilities.
Author: Hélène Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1788015150
Category : Science
Languages : en
Pages : 375
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Book Description
With a foreword from leading organic chemist Professor Paul Wender, this book collects the major developments reported in the past thirty years in the field of enantioselective reactions promoted by chiral cobalt catalysts, illustrating the power of these green catalysts to provide all types of organic reactions from the basic to completely novel methodologies. The search for new methodologies to prepare optically pure products is one of the most active areas of research in organic synthesis. Of the methods available for preparing chiral compounds, catalytic asymmetric synthesis has attracted the most attention. In particular, asymmetric transition-metal catalysis is a powerful tool for performing reactions in a highly enantioselective fashion. Efforts to develop new asymmetric transformations have previously focused on the use of rare metals such as titanium, palladium, iridium and gold. However, the ever-growing need for environmentally friendly catalytic processes has prompted chemists to focus on the more abundant and less toxic first-row transition metals, such as cobalt, to develop new catalytic systems. The ability of cobalt catalysts to adopt unexpected reaction pathways has led to an impressive number of enantioselective cobalt-promoted transformations being developed over the past three decades. These have included the synthesis of many different types of products, often under relatively mild conditions and with remarkable enantioselectivities. This book is a useful reference resource for chemists, both academic and industrial, working in organic synthesis and interested in greener or more economical catalytic alternatives.
Author: Helene Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1782626700
Category : Science
Languages : en
Pages : 405
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Book Description
Due to the lower costs of nickel catalysts and the high abundance of nickel complexes, enantioselective nickel-mediated transformations have received a continuous and growing attention in recent years. This book demonstrates the diversity of chemistry catalysed by chiral nickel catalysts. Discussing several different enantioselective transformations, this book presents the impressive range of uses that have been found for novel and already known nickel chiral catalysts, from basic organic transformations to completely novel methodologies including fascinating one-pot domino and multicomponent reactions. This much-needed book is ideal for researchers and industrialists in organic chemistry, synthesis and medicinal chemistry.
Author: Pher G. Andersson
Publisher: Springer Science & Business Media
ISBN: 364215333X
Category : Science
Languages : en
Pages : 244
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Book Description
From the contents: Robert H Crabtree: Introduction and History. - Montserrat Diéguez, Oscar Pàmies and Carmen Claver: Iridium-catalysed hydrogenation using phosphorous ligands. - David H. Woodmansee and Andreas Pfaltz: Iridium Catalyzed Asymmetric Hydrogenation of Olefins with Chiral N,P and C,N Ligands. - Ourida Saidi and Jonathan M J Williams: Iridium-catalyzed Hydrogen Transfer Reactions. - John F. Bower and Michael J. Krische: Formation of C-C Bonds via Iridium Catalyzed Hydrogenation and Transfer Hydrogenation. - Jongwook Choi, Alan S. Goldman: Ir-Catalyzed Functionalization of CH Bonds. - Mark P. Pouy and John F. Hartwig: Iridium-Catalyzed Allylic Substitution. - Daniel Carmona and Luis A. Oro: Iridium-catalyzed 1.3-dipolar cycloadditions.
Author: Ilya D. Gridnev
Publisher: CRC Press
ISBN: 1498726550
Category : Science
Languages : en
Pages : 234
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Book Description
The field of asymmetric catalysis is currently one of the hottest areas in chemistry. This unique book focuses on the mechanism of enantioselectivity in asymmetric catalysis, rather than asymmetric catalysis from the synthetic view. It describes reliable, experimentally and computationally supported mechanisms, and discusses the danger of so-called "plausible" or "accepted" mechanisms leading to wrong conclusions. It draws parallels to enzymatic catalysis in biochemistry, and examines in detail the physico-chemical aspects of enantioselective catalysis.
Author: Elias J. Corey
Publisher: Elsevier
ISBN: 0128001518
Category : Science
Languages : en
Pages : 334
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Book Description
Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. - In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. - Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. - Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules - Clearly explains stereochemical synthesis in theory and practice - Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis - Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages
Author: Helene Pellissier
Publisher: John Wiley & Sons
ISBN: 3527822526
Category : Science
Languages : en
Pages : 342
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Book Description
Introduces an innovative and outstanding tool for the easy synthesis of complex chiral structures in a single step Covering all of the literature since the beginning of 2006, this must-have book for chemists collects the major progress in the field of enantioselective one-, two-, and multicomponent domino reactions promoted by chiral metal catalysts. It clearly illustrates how enantioselective metal-catalyzed processes constitute outstanding tools for the development of a wide variety of fascinating one-pot asymmetric domino reactions, thereby allowing many complex products to be easily generated from simple materials in one step. The book also strictly follows the definition of domino reactions by Tietze as single-, two-, as well as multicomponent transformations. Asymmetric Metal Catalysis in Enantioselective Domino Reactions is divided into twelve chapters, dealing with enantioselective copper-, palladium-, rhodium-, scandium-, silver-, nickel-, gold-, magnesium-, cobalt-, zinc-, yttrium and ytterbium-, and other metal-catalyzed domino reactions. Most of the chapters are divided into two parts dealing successively with one- and two-component domino reactions, and three-component processes. Each part is subdivided according to the nature of domino reactions. Each chapter of the book includes selected applications of synthetic methodologies to prepare natural and biologically active products. -Presents the novel combination of asymmetric metal catalysis with the concept of fascinating domino reactions, which allows high molecular complexity with a remarkable level of enantioselectivity -Showcases an incredible tool synthesizing complex and diverse chiral structures in a single reaction step -Includes applications in total synthesis of natural products and biologically active compounds -Written by a renowned international specialist in the field -Stimulates the design of novel asymmetric domino reactions and their use in the synthesis of natural products, pharmaceuticals, agrochemicals, and materials Asymmetric Metal Catalysis in Enantioselective Domino Reactions will be of high interest to synthetic, organic, medicinal, and catalytic chemists in academia and R&D departments.
Author: Yiming Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 243
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Book Description
The activation of relatively unreactive carbon-carbon (C-C) multiple bonds is an important tool for the introduction of functional groups and stereochemical information in organic molecules. In recent years, the use of electrophilic cationic gold(I) complexes for the functionalization of alkynes and allenes has seen rapid development. An especially general application of gold catalysis is the nucleophilic trapping of gold-activated ð bond to give a heterocyclic compound. In the case of allenes, chiral ligands have been used to generate product with excellent enantiocontrol. In the first part of this Thesis we report studies on the development of an enantioselective cyclization using the gold-catalyzed transformation of propargyl esters to generate allenes in situ. A subsequent gold-catalyzed dynamic kinetic asymmetric cyclization of a phenol onto the allene resulted in the generation of enantioenriched cyclized chromanone derivatives from racemic starting material. The optimal catalyst for this transformation was a (biscarbene)digold(I) complex, which delivered better enantioselectivities than previously known phosphine-gold and phosphoramidite-gold complexes. Electrophilic sources of the halogens (fluorine, chlorine, bromine, and iodine) activate C-C multiple bonds in much the same way as gold(I) complexes, but the electrophilic atom of the reagent is incorporated into the final product. Because halogen atoms are amenable to further functional group manipulation and are also present in complex natural products, the enantioselective synthesis of halofunctionalized products from alkenes is an important synthetic goal. Typically, enantioselectivity is achieved using a chiral catalyst to activate the electrophilic reagent. However, high enantioselectivities may be hampered by uncatalyzed background reactivity. The Toste research group has introduced a new approach for electrophilic functionalization (chiral anion phase transfer catalysis) by inducing ion pairing between a phosphate anion chiral source and a cationic electrophilic reagent by phase transfer. This concept was initially demonstrated for fluorination, using the cationic reagent F-TEDA-BF4 (Selectfluor®). In the second part of the Thesis, we report studies on the extension of this strategy to the heavier halogens. With the successful development of bromination and iodination reagents suitable for chiral anion phase transfer, we applied these reagents to the synthesis of halogenated benzoxazines with high levels of enantioselectivity.
