Cardiovascular Risk in Rheumatoid Arthritis and Other Inflammatory Disorders PDF Download
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Author:
Publisher:
ISBN: 9789463327435
Category :
Languages : en
Pages : 0
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Book Description
The risk for cardiovascular disease in rheumatoid arthritis (RA) patients has been a concern for the last two decades; since research showed that this risk is increased compared to the general population. In 2009, the European League Against Rheumatism (EULAR) task force recommended screening, identification of CVD risk factors and CVD risk management in RA patients. Since then, substantial new insights in this field has been published, largely based on expert opinion. In the updated recommendations on cardiovascular risk management from the EULAR task force, three overarching principles and 10 recommendations were formulated. These recommendations, are meant to facilitate CVD risk management in daily clinical practice, ultimately leading to a decreased CVD burden in RA patients. We conducted the I-CaRe Project in Reade, Amsterdam, and Antonius Hospital, Sneek to investigate and optimize cardiovascular risk management. Over half of our patients (53%) were found to have a high cardiovascular risk. Furthermore, we identified (under) treatment of CV risk factors in these patients. In total, 69% had an indication to use cholesterol lowering or antihypertensive drugs. Of those, 42% received inadequate treatment and 40% received no treatment at all. Despite clear guidelines, both local (Dutch guideline) and international, like the EUAR guideline, and the active implementation of a screening program, we have to conclude that optimal CV risk management remains a major challenge in the RA population. Not only cardiovascular risk management, but also the prediction of cardiovascular risk itself remains a challenge in the RA population. It appears to make most sense to calculate cardiovascular risk during the period that RA patients are in a state of low or stable disease activity. This of course needs to be further investigated by studies using longer follow up.
Author:
Publisher:
ISBN: 9789463327435
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
The risk for cardiovascular disease in rheumatoid arthritis (RA) patients has been a concern for the last two decades; since research showed that this risk is increased compared to the general population. In 2009, the European League Against Rheumatism (EULAR) task force recommended screening, identification of CVD risk factors and CVD risk management in RA patients. Since then, substantial new insights in this field has been published, largely based on expert opinion. In the updated recommendations on cardiovascular risk management from the EULAR task force, three overarching principles and 10 recommendations were formulated. These recommendations, are meant to facilitate CVD risk management in daily clinical practice, ultimately leading to a decreased CVD burden in RA patients. We conducted the I-CaRe Project in Reade, Amsterdam, and Antonius Hospital, Sneek to investigate and optimize cardiovascular risk management. Over half of our patients (53%) were found to have a high cardiovascular risk. Furthermore, we identified (under) treatment of CV risk factors in these patients. In total, 69% had an indication to use cholesterol lowering or antihypertensive drugs. Of those, 42% received inadequate treatment and 40% received no treatment at all. Despite clear guidelines, both local (Dutch guideline) and international, like the EUAR guideline, and the active implementation of a screening program, we have to conclude that optimal CV risk management remains a major challenge in the RA population. Not only cardiovascular risk management, but also the prediction of cardiovascular risk itself remains a challenge in the RA population. It appears to make most sense to calculate cardiovascular risk during the period that RA patients are in a state of low or stable disease activity. This of course needs to be further investigated by studies using longer follow up.
Author: Hani Almoallim
Publisher: Springer Nature
ISBN: 9811583234
Category : Medical
Languages : en
Pages : 562
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Book Description
This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.
Author: Udi Nussinovitch
Publisher: Academic Press
ISBN: 0128032685
Category : Medical
Languages : en
Pages : 768
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Book Description
The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. - A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. - Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. - Presents an up-to-date "level of evidence and "strengths of recommendations for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.
Author: Anne Grete Semb
Publisher: Springer
ISBN: 3319267825
Category : Medical
Languages : en
Pages : 122
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Book Description
This book is a practical and up-to-date review that discusses the impact of traditional cardiovascular risk factors in patients with rheumatoid arthritis, the effect of rheumatoid arthritis disease activity and severity on cardiovascular comorbidity, and the influence of rheumatoid arthritis drug therapy on cardiovascular risk. This title also explores cardiovascular disease as a manifestation of rheumatoid arthritis and highlights the available methods for screening and diagnosing these conditions. Current and emerging therapies to aid clinicians in the daily management of their patients are also featured in this title. Busy healthcare professionals who are looking for a collaborative approach to these conditions will benefit from this comprehensive overview.
Author: Filippo Crea
Publisher: Springer Science & Business Media
ISBN: 8847053676
Category : Medical
Languages : en
Pages : 263
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Book Description
In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Author: Paul Emery
Publisher:
ISBN: 9781416027676
Category : Rheumatoid arthritis
Languages : en
Pages : 0
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Book Description
This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.
Author: Alberto Lo Gullo
Publisher: Frontiers Media SA
ISBN: 2832500781
Category : Medical
Languages : en
Pages : 171
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Book Description
Author: Alexandru Caraba
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0
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Book Description
Rheumatoid arthritis (RA), one of the most common inflammatory rheumatic diseases. It is defined as a chronic destructive and deforming arthropathy; it also finds its expression through systemic manifestations. RA has an undulating evolution, with remissions and relapses. Atherosclerotic cardiovascular disease represents one of the most common extra-articular manifestations of RA. It is known that the cardiovascular (CV) morbidity and mortality represent one of the leading causes of reduced life expectancy in RA. Patients with RA develop a premature and accelerated atherosclerosis, explaining the high incidence and prevalence of angina, myocardial infarction, congestive heart failure, stroke, peripheral artery disease, and the need for revascularization. Traditional risk factors (arterial hypertension, obesity, smoking, dyslipidemia, insulin resistance and metabolic syndrome, diabetes mellitus, male gender, physical inactivity) interplay with RA-related risk factors, generating endothelial dysfunction, arterial stiffness, carotid plaque, and atherosclerosis. Traditional cardiovascular risk factors alone cannot explain the increased incidence of premature and accelerated atherogenesis. Chronic inflammation, hyperhomocysteinemia, and hypercoagulation act as novel cardiovascular risk factors. Rheumatoid inflammation exerts direct effects on vessels, or by means of altered traditional risk factors. Antirheumatic drugs may promote atherogenesis or by reducing systemic inflammation may decrease cardiovascular risk. EULAR recommendations require annual cardiovascular risk assessment.
Author: Robert D. Ficalora
Publisher: Oxford University Press, USA
ISBN: 0199985871
Category : Medical
Languages : en
Pages : 164
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Book Description
Companion volume to: Mayo Clinic internal medicine board review. 10th ed. c2013.
Author: Reem Hamdy A. Mohammed
Publisher: BoD – Books on Demand
ISBN: 1839625325
Category : Medical
Languages : en
Pages : 170
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Book Description
Rheumatoid Arthritis - Other Perspectives towards Better Practice sheds light on the disease process of rheumatoid arthritis as well as the disease’s related comorbidities. Chapters cover such topics as immune-pathogenic theories, classification criteria, available composite measures of disease assessment, and latest available therapeutic approaches.
