Cardiac Arrhythmias: New Therapeutic Drugs and Devices PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Cardiac Arrhythmias: New Therapeutic Drugs and Devices PDF full book. Access full book title Cardiac Arrhythmias: New Therapeutic Drugs and Devices by J. Morganroth. Download full books in PDF and EPUB format.
Author: J. Morganroth
Publisher: Springer Science & Business Media
ISBN: 1461325951
Category : Medical
Languages : en
Pages : 359
Get Book Here
Book Description
In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .
Author: J. Morganroth
Publisher: Springer Science & Business Media
ISBN: 1461325951
Category : Medical
Languages : en
Pages : 359
Get Book Here
Book Description
In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .
Author: I. Eli Ovsyshcher, MD, PhD, FESC, FACC
Publisher: Wiley-Blackwell
ISBN: 9780879934552
Category : Medical
Languages : en
Pages : 423
Get Book Here
Book Description
The final decades of this century have been a period of expansive growth for the electrophysiological management of cardiac arrhythmias. Subsequently, the rapid and widespread clinical application of so many technological advances has made the exchange of ideas in this field an urgent necessity. Cardiac Arrhythmias and Device Therapy: Results and Perspectives for the New Century addresses the issue by gathering current, relevant information in a clear, user-friendly format. This book covers a broad spectrum of subjects, including basic electrophysiology (impulse propagation, subthreshold stimulation, genetics and the molecular base of arrhythmias), invasive and noninvasive clinical electrophysiology, and the clinical aspects of cardiac pacing and defibrillation. It provides a comprehensive review of various methods of treatment of atrial fibrillation, and of the role of pacing in prevention of atrial fibrillation and in treatment of congestive heart failure, dilated, hypertrophic, and restrictive cardiomyopathies. The results of recent clinical trials in cardiac pacing and in the prevention and treatment of malignant venticular arrhythmias are also presented. Special sections have been dedicated to the various aspects of preventing sudden death, including the use of internal and external defibrillation. Finally, the book offers a current review of "hot" topics, with personal experiences and critical evaluations by the world-renowned authors. This book will be of interest to all cardiologists, EP technicians, and health care personnel involved in the diagnosis and management of arrhythmias, who wish to gain a complete perspective on modern pacing and electrophysiology.
Author: Raymond Woosley
Publisher: CRC Press
ISBN: 9780824781644
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
This vitally important reference traces the progress of antiarrhythmic drug trials and treatment methods-from the vantage point of the clinicians who designed and conducted the studies to objective views of the strengths and weaknesses of the results, identifying unresolved questions or newly created issues. Reviews significant studies in chronological order-providing a clear, informative account of how current thinking about arrhythmia treatment has evolved. Written by over 35 leading experts in the field, Clinical Trials on the Treatment of Arrhythmias emphasizes the need for science-based therapeutics and rigorously controlled clinical trials of drugs and implantable devices compares electrocardiographic monitoring with electrophysiological techniques for arrhythmia management analyzes the landmark Cardiac Arrhythmia Suppression Trial (CAST) evaluates the effectiveness of amiodarone describes sodium and potassium channel blockers and the development of drugs that slow conduction velocity and prolong repolarization and refractoriness investigates the effects of the d-isomer of sotalol on mortality critiques studies on the established efficacy of implantable devices versus amiodarone to benefit post-bypass surgery patients and more! Containing over 600 literature citations, Clinical Trials on the Treatment of Arrhythmias is an invaluable resource for cardiologists and cardiovascular specialists, pharmacologists, pharmaceutical researchers, and graduate and medical school students in these disciplines.
Author: Ruey J. Sung
Publisher: Springer Science & Business Media
ISBN: 9401143714
Category : Medical
Languages : en
Pages : 826
Get Book Here
Book Description
This new edition provides up-to-date comprehensive coverage of the rapidly evolving field of clinical cardiac electrophysiology. It is designed for physicians, cardiologists, cardiac electrophysiologists, and allied professionals practising or learning the speciality of clinical cardiac electrophysiology. This textbook - written entirely by two practising authorities in the field - offers a cohesive and comprehensive summary of the principles and practice of clinical cardiac electrophysiology. The authors emphasize the clinical approach to the patient and provide a fundamental, yet thorough, discussion of the primary therapeutic modalities used today in a state-of-the-art electrophysiology laboratory, including the latest pharmacotherapy options, catheter ablation treatment, and the newest implantable devices. The authors provide the reader with a concise, organized discussion of the management of patients with benign to life-threatening arrhythmias using the newest concepts, equipment, and techniques of diagnostic and therapeutic electrophysiology.
Author: Robert E. Kass
Publisher: Springer Science & Business Media
ISBN: 9783540249672
Category : Medical
Languages : en
Pages : 384
Get Book Here
Book Description
This book incorporates the most up-to date information related to mechanisms and treatment of cardiac arrhythmia. Many of the topics discussed in this text reflect very recently undertaken research directions including genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These new approaches and implementations of anti-arrhythmic therapy derive from many decades of research as outlined in the first chapter by distinguished Professors Michael Rosen (Columbia University) and Michiel Janse (University of Amsterdam). The text covers changes in approaches to therapy over time, arrhythmias in multiple cardiac regions and over many scales, from gene to protein to cell to tissue to organ.
Author: J. Morganroth
Publisher:
ISBN: 9781461338772
Category :
Languages : en
Pages : 324
Get Book Here
Book Description
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 030915698X
Category : Medical
Languages : en
Pages : 304
Get Book Here
Book Description
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Author: Gerry Kaye
Publisher: Karger Medical and Scientific Publishers
ISBN: 1908541253
Category : Medical
Languages : en
Pages : 150
Get Book Here
Book Description
Recent progress in interventional therapies has revolutionized the management of cardiac arrhythmias, resulting in a remarkable improvement in outcomes for patients. Yet the diagnosis and management of arrhythmias are still viewed as a complex and inaccessible area of modern cardiology. 'Fast Facts: Cardiac Arrhythmias' cuts through the technical detail to provide a better understanding of how the patient with arrhythmia presents, and how the problem should be best investigated and managed. Highlights include: • Succinct descriptions with clear well-annotated illustrations of normal conduction and the mechanisms of arrhythmias • A simple classification of arrhythmias based on 12-lead ECG patterns • A comprehensive review of presenting signs and symptoms, with key questions to ask the patient • A logical approach to investigation: predict it (history and examination), wait for it (monitoring) or provoke it (electrophysiological testing) • Practical information on management options: pharmacological therapy, direct cardioversion, catheter ablation and cardiac devices • The latest international guidelines on atrial fibrillation and catheter and surgical ablation • Important pharmacological updates, including the latest thinking on anticoagulation. This highly readable handbook is a practical resource for all primary care physicians, cardiologists in training, cardiac nurses, technicians and medical students seeking a better understanding of the mechanisms of arrhythmias and the contemporary therapies available, with a view to improving patient care. Contents: • Conduction within the heart • Classification and mechanisms of arrhythmias • Presenting signs and symptoms • Investigation • Management principles • Supraventricular arrhythmias • Atrial flutter • Atrial fibrillation • Ventricular arrhythmias • Rare and unusual arrhythmias • Cardiac devices: Pacemakers and defibrillators • Useful resources
Author: David H. Bennett
Publisher: John Wiley & Sons
ISBN: 1118432401
Category : Medical
Languages : en
Pages : 336
Get Book Here
Book Description
Reviews of previous editions: "...a well conceived practical guide to the interpretation andtreatment of the main cardiac rhythm disturbances." —Lancet "This book presents a concise and simplified approach to thediagnosis and management of abnormalities in cardiac rhythm.... Oneof the book's strengths is the number and quality ofelectrocardiographic tracings" —New England Journal of Medicine "...this book provides an excellent foundation for all thoseinvolved in the care of arrhythmia patients" —British Journal of Hospital Medicine "…would recommend it unreservedly to anaesthetists whowish to improve their knowledge of cardiac arrhythmias" —British Journal of Anaesthesia "This book about cardiac arrhythmias is of much educationalvalue" —European Heart Journal A trusted source for junior doctors, students, nurses andcardiac technicians for over 30 years, the new edition of thisclassic reference continues the winning formula of previouseditions while at the same time incorporating essential new contenton today's most important clinical topics, including: Atrial fibrillation: ablation, drugs, rate control versusrhythm control, risk of systemic embolism, prognosis Indications for and management of implantable defibrillatorsincluding complications such as arrhythmia storms Indications for pacemaker implantation Anticoagulant therapy (for atrial fibrillation) Long QT syndromes and other channelopathies Recently-approved anti-arrhythmia drugs The 8th edition also features the latest guidelines on ECGscreening of athletes and clear guidance for anaesthetists andsurgeons dealing with patients with arrhythmias an/or implantabledevices. Rich with example ECGs and designed for ease of access toinformation, Bennett's Cardiac Arrhythmias is the referenceyou can trust to help you master arrhythmia diagnosis and provideoptimal treatment of any patient under your care.
Author: George Edward Billman
Publisher: John Wiley & Sons
ISBN: 0470261005
Category : Medical
Languages : en
Pages : 610
Get Book Here
Book Description
PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.
