Author: Fabien Deligey
Publisher:
ISBN:
Category :
Languages : fr
Pages : 0
Book Description
Actuellement, une voie de développement de formulations médicamenteuses novatrices passe par la vectorisation de principes actifs connus dans des nanoparticules. Des matériaux hybrides sont ainsi formés, possédant de nouvelles propriétés liées au nano-confinement. Les travaux ici menés s'appuient sur la sensibilité de la Résonance Magnétique Nucléaire (RMN) du solide aux phénomènes prenant place aux échelles moléculaires, pour effectuer une analyse structurelle et dynamique de deux vecteurs. Le premier, hydrophile, est une matrice nanoporeuse de silice sol-gel, dans laquelle sont confinés des complexes de nitroprussiate de sodium isolés. À partir de mesures de relaxation de spin et d'anisotropie de déplacement chimique, différents régimes de dynamique moléculaire sont mis en évidence. Ils sont modulés par la présence de molécules de solvant résiduelles (H2O). Des gammes de température et d'hydratation sont identifiées, pour lesquelles le complexe reste associé malgré un état ''pseudo-liquide''. Dans la condition limite d'absence d'eau, la restriction du mouvement des complexes confinés est élucidée en caractérisant les interactions dipolaires hôtes / invités. Le second système allie la double vectorisation de la curcumine hydrophobe dans des nanoparticules de lipides solides encapsulées dans une matrice de silice (SBA-15). Une stratégie d'étude conjointe par RMN du solide et par calorimétrie différentielle à balayage (DSC) est mise en place. Les résultats montrent que d'autres facteurs que la compartimentalisation (polymorphisme, dynamique moléculaire des composés hôtes) doivent également être pris en compte pour la compréhension des propriétés de ces matériaux très hétérogènes. Malgré le recours à une instrumentation RMN de dernière génération (spectromètre 1GHz, sonde MAS 1.3mm), la présence de principe actif est observée uniquement dans les compartiments de tensioactif. Ces résultats permettent d'émettre de nouvelles hypothèses sur la distribution du principe actif, tout en montrant les limites de l'approche RMN basée uniquement sur l'étude des noyaux 1H.
Caractérisation RMN de matériaux hybrides pour l'encapsulation de principes actifs
Author: Fabien Deligey
Publisher:
ISBN:
Category :
Languages : fr
Pages : 0
Book Description
Actuellement, une voie de développement de formulations médicamenteuses novatrices passe par la vectorisation de principes actifs connus dans des nanoparticules. Des matériaux hybrides sont ainsi formés, possédant de nouvelles propriétés liées au nano-confinement. Les travaux ici menés s'appuient sur la sensibilité de la Résonance Magnétique Nucléaire (RMN) du solide aux phénomènes prenant place aux échelles moléculaires, pour effectuer une analyse structurelle et dynamique de deux vecteurs. Le premier, hydrophile, est une matrice nanoporeuse de silice sol-gel, dans laquelle sont confinés des complexes de nitroprussiate de sodium isolés. À partir de mesures de relaxation de spin et d'anisotropie de déplacement chimique, différents régimes de dynamique moléculaire sont mis en évidence. Ils sont modulés par la présence de molécules de solvant résiduelles (H2O). Des gammes de température et d'hydratation sont identifiées, pour lesquelles le complexe reste associé malgré un état ''pseudo-liquide''. Dans la condition limite d'absence d'eau, la restriction du mouvement des complexes confinés est élucidée en caractérisant les interactions dipolaires hôtes / invités. Le second système allie la double vectorisation de la curcumine hydrophobe dans des nanoparticules de lipides solides encapsulées dans une matrice de silice (SBA-15). Une stratégie d'étude conjointe par RMN du solide et par calorimétrie différentielle à balayage (DSC) est mise en place. Les résultats montrent que d'autres facteurs que la compartimentalisation (polymorphisme, dynamique moléculaire des composés hôtes) doivent également être pris en compte pour la compréhension des propriétés de ces matériaux très hétérogènes. Malgré le recours à une instrumentation RMN de dernière génération (spectromètre 1GHz, sonde MAS 1.3mm), la présence de principe actif est observée uniquement dans les compartiments de tensioactif. Ces résultats permettent d'émettre de nouvelles hypothèses sur la distribution du principe actif, tout en montrant les limites de l'approche RMN basée uniquement sur l'étude des noyaux 1H.
Publisher:
ISBN:
Category :
Languages : fr
Pages : 0
Book Description
Actuellement, une voie de développement de formulations médicamenteuses novatrices passe par la vectorisation de principes actifs connus dans des nanoparticules. Des matériaux hybrides sont ainsi formés, possédant de nouvelles propriétés liées au nano-confinement. Les travaux ici menés s'appuient sur la sensibilité de la Résonance Magnétique Nucléaire (RMN) du solide aux phénomènes prenant place aux échelles moléculaires, pour effectuer une analyse structurelle et dynamique de deux vecteurs. Le premier, hydrophile, est une matrice nanoporeuse de silice sol-gel, dans laquelle sont confinés des complexes de nitroprussiate de sodium isolés. À partir de mesures de relaxation de spin et d'anisotropie de déplacement chimique, différents régimes de dynamique moléculaire sont mis en évidence. Ils sont modulés par la présence de molécules de solvant résiduelles (H2O). Des gammes de température et d'hydratation sont identifiées, pour lesquelles le complexe reste associé malgré un état ''pseudo-liquide''. Dans la condition limite d'absence d'eau, la restriction du mouvement des complexes confinés est élucidée en caractérisant les interactions dipolaires hôtes / invités. Le second système allie la double vectorisation de la curcumine hydrophobe dans des nanoparticules de lipides solides encapsulées dans une matrice de silice (SBA-15). Une stratégie d'étude conjointe par RMN du solide et par calorimétrie différentielle à balayage (DSC) est mise en place. Les résultats montrent que d'autres facteurs que la compartimentalisation (polymorphisme, dynamique moléculaire des composés hôtes) doivent également être pris en compte pour la compréhension des propriétés de ces matériaux très hétérogènes. Malgré le recours à une instrumentation RMN de dernière génération (spectromètre 1GHz, sonde MAS 1.3mm), la présence de principe actif est observée uniquement dans les compartiments de tensioactif. Ces résultats permettent d'émettre de nouvelles hypothèses sur la distribution du principe actif, tout en montrant les limites de l'approche RMN basée uniquement sur l'étude des noyaux 1H.
N-Heterocyclic Carbenes
Author: Silvia Diez-Gonzalez
Publisher: Royal Society of Chemistry
ISBN: 1782626816
Category : Science
Languages : en
Pages : 637
Book Description
In less than 20 years N-heterocyclic carbenes (NHCs) have become well-established ancillary ligands for the preparation of transition metal-based catalysts. This is mainly due to the fact that NHCs tend to bind strongly to metal centres, avoiding the need of excess ligand in catalytic reactions. Also, NHC‒metal complexes are often insensitive to air and moisture, and have proven remarkably resistant to oxidation. This book showcases the wide variety of applications of NHCs in different chemistry fields beyond being simple phosphine mimics. This second edition has been updated throughout, and now includes a new chapter on NHC‒main group element complexes. It covers the synthesis of NHC ligands and their corresponding metal complexes, as well as their bonding and stereoelectronic properties and applications in catalysis. This is complemented by related topics such as organocatalysis and biologically active complexes. Written for organic and inorganic chemists, this book is ideal for postgraduates, researchers and industrialists.
Publisher: Royal Society of Chemistry
ISBN: 1782626816
Category : Science
Languages : en
Pages : 637
Book Description
In less than 20 years N-heterocyclic carbenes (NHCs) have become well-established ancillary ligands for the preparation of transition metal-based catalysts. This is mainly due to the fact that NHCs tend to bind strongly to metal centres, avoiding the need of excess ligand in catalytic reactions. Also, NHC‒metal complexes are often insensitive to air and moisture, and have proven remarkably resistant to oxidation. This book showcases the wide variety of applications of NHCs in different chemistry fields beyond being simple phosphine mimics. This second edition has been updated throughout, and now includes a new chapter on NHC‒main group element complexes. It covers the synthesis of NHC ligands and their corresponding metal complexes, as well as their bonding and stereoelectronic properties and applications in catalysis. This is complemented by related topics such as organocatalysis and biologically active complexes. Written for organic and inorganic chemists, this book is ideal for postgraduates, researchers and industrialists.
Buyology
Author: Martin Lindstrom
Publisher: Currency
ISBN: 0385523890
Category : Business & Economics
Languages : en
Pages : 274
Book Description
NEW YORK TIMES BESTSELLER • “A fascinating look at how consumers perceive logos, ads, commercials, brands, and products.”—Time How much do we know about why we buy? What truly influences our decisions in today’s message-cluttered world? In Buyology, Martin Lindstrom presents the astonishing findings from his groundbreaking three-year, seven-million-dollar neuromarketing study—a cutting-edge experiment that peered inside the brains of 2,000 volunteers from all around the world as they encountered various ads, logos, commercials, brands, and products. His startling results shatter much of what we have long believed about what captures our interest—and drives us to buy. Among the questions he explores: • Does sex actually sell? • Does subliminal advertising still surround us? • Can “cool” brands trigger our mating instincts? • Can our other senses—smell, touch, and sound—be aroused when we see a product? Buyology is a fascinating and shocking journey into the mind of today's consumer that will captivate anyone who's been seduced—or turned off—by marketers' relentless attempts to win our loyalty, our money, and our minds.
Publisher: Currency
ISBN: 0385523890
Category : Business & Economics
Languages : en
Pages : 274
Book Description
NEW YORK TIMES BESTSELLER • “A fascinating look at how consumers perceive logos, ads, commercials, brands, and products.”—Time How much do we know about why we buy? What truly influences our decisions in today’s message-cluttered world? In Buyology, Martin Lindstrom presents the astonishing findings from his groundbreaking three-year, seven-million-dollar neuromarketing study—a cutting-edge experiment that peered inside the brains of 2,000 volunteers from all around the world as they encountered various ads, logos, commercials, brands, and products. His startling results shatter much of what we have long believed about what captures our interest—and drives us to buy. Among the questions he explores: • Does sex actually sell? • Does subliminal advertising still surround us? • Can “cool” brands trigger our mating instincts? • Can our other senses—smell, touch, and sound—be aroused when we see a product? Buyology is a fascinating and shocking journey into the mind of today's consumer that will captivate anyone who's been seduced—or turned off—by marketers' relentless attempts to win our loyalty, our money, and our minds.
Encapsulations
Author: Alexandru Grumezescu
Publisher: Academic Press
ISBN: 0128043784
Category : Science
Languages : en
Pages : 926
Book Description
Encapsulations, a volume in the Nanotechnology in the Agri-Food Industry series,presents key elements in establishing food quality through the improvement of food flavor and aroma. The major benefits of nanoencapsulation for food ingredients include improvement in bioavailability of flavor and aroma ingredients, improvement in solubility of poor water-soluble ingredients, higher ingredient retention during production process, higher activity levels of encapsulated ingredients, improved shelf life, and controlled release of flavor and aroma. This volume discusses main nanoencapsulation processes such as spray drying, melt injection, extrusion, coacervation, and emulsification. The materials used in nanoencapsulation include lipids, proteins, carbohydrates, cellulose, gums, and food grade polymers. Applications and benefits of nanoencapsulation such as controlled release, protections, and taste masking will be explained in detail. Includes the most up-to-date information on nanoencapsulation and nanocontainer-based delivery of antimicrobials Presents nanomaterials for innovation based on scientific advancements in the field Provides control release strategies to enhance bioactivity, including methods and techniques for research and innovation Provides useful tools to improve the delivery of bioactive molecules and living cells into foods
Publisher: Academic Press
ISBN: 0128043784
Category : Science
Languages : en
Pages : 926
Book Description
Encapsulations, a volume in the Nanotechnology in the Agri-Food Industry series,presents key elements in establishing food quality through the improvement of food flavor and aroma. The major benefits of nanoencapsulation for food ingredients include improvement in bioavailability of flavor and aroma ingredients, improvement in solubility of poor water-soluble ingredients, higher ingredient retention during production process, higher activity levels of encapsulated ingredients, improved shelf life, and controlled release of flavor and aroma. This volume discusses main nanoencapsulation processes such as spray drying, melt injection, extrusion, coacervation, and emulsification. The materials used in nanoencapsulation include lipids, proteins, carbohydrates, cellulose, gums, and food grade polymers. Applications and benefits of nanoencapsulation such as controlled release, protections, and taste masking will be explained in detail. Includes the most up-to-date information on nanoencapsulation and nanocontainer-based delivery of antimicrobials Presents nanomaterials for innovation based on scientific advancements in the field Provides control release strategies to enhance bioactivity, including methods and techniques for research and innovation Provides useful tools to improve the delivery of bioactive molecules and living cells into foods
Phosphorus Compounds
Author: Maurizio Peruzzini
Publisher: Springer Science & Business Media
ISBN: 9048138175
Category : Science
Languages : en
Pages : 477
Book Description
Each chapter of Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences have been carefully selected by the editors in order to represent a state-of-the-art overview of how phosphorus chemistry can provide solutions in various fields of applications. The editors have assembled an international array of world-renowned scientists and each chapter is written by experts in the fields of synthetic chemistry, homogeneous catalysis, dendrimers, theoretical calculations, materials science, and medicinal chemistry with a special focus on the chemistry of phosphorus compounds. Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences is of interest to a general readership ranging from advanced university course students to experts in academia and industry.
Publisher: Springer Science & Business Media
ISBN: 9048138175
Category : Science
Languages : en
Pages : 477
Book Description
Each chapter of Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences have been carefully selected by the editors in order to represent a state-of-the-art overview of how phosphorus chemistry can provide solutions in various fields of applications. The editors have assembled an international array of world-renowned scientists and each chapter is written by experts in the fields of synthetic chemistry, homogeneous catalysis, dendrimers, theoretical calculations, materials science, and medicinal chemistry with a special focus on the chemistry of phosphorus compounds. Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences is of interest to a general readership ranging from advanced university course students to experts in academia and industry.
In-Situ Gelling Polymers
Author: Xian Jun Loh
Publisher: Springer
ISBN: 9812871527
Category : Technology & Engineering
Languages : en
Pages : 229
Book Description
This book presents the research involving in situ gelling polymers and can be used as a guidebook for academics, industrialists and postgraduates interested in this area. This work summaries the academic contributions from the top authorities in the field and explore the fundamental principles of in situ gelling polymeric networks, along with examples of their major applications. This book aims to provide an up-to-date resource of in situ gelling polymer research.
Publisher: Springer
ISBN: 9812871527
Category : Technology & Engineering
Languages : en
Pages : 229
Book Description
This book presents the research involving in situ gelling polymers and can be used as a guidebook for academics, industrialists and postgraduates interested in this area. This work summaries the academic contributions from the top authorities in the field and explore the fundamental principles of in situ gelling polymeric networks, along with examples of their major applications. This book aims to provide an up-to-date resource of in situ gelling polymer research.
Wood Adhesives
Author: Antonio Pizzi
Publisher: CRC Press
ISBN: 9004190937
Category : Technology & Engineering
Languages : en
Pages : 464
Book Description
Wood adhesives are of tremendous industrial importance, as more than two-thirds of wood products in the world today are completely or partially bonded together using a variety of adhesives. Adhesive bonding offers many advantages over other joining methods for wood components, and there has been a great deal of R& D activity in devising new wood adhesives or improving the existing ones. The modern mantra in all industrial sectors is: "think green, go green," which has attracted much attention in the wood adhesive industry. Therefore, there is also a lot of research activity in synthesizing environmentally benign and human-friendly wood adhesives. This book is divided into four parts: Part 1: Fundamental Adhesion Aspects in Wood Bonding; Part 2: Synthetic Adhesives; Part 3: Environment-friendly adhesives; and Part 4: Wood Welding and General Paper. It addresses many different types of wood adhesives, as well as bonding (welding) of wood components without adhesives, a more recent development. The information contained in this book is valuable for individuals engaged in all aspects of wood adhesion and adhesives and, hopefully, will inspire new ideas in wood adhesives, a topic of vital industrial importance.
Publisher: CRC Press
ISBN: 9004190937
Category : Technology & Engineering
Languages : en
Pages : 464
Book Description
Wood adhesives are of tremendous industrial importance, as more than two-thirds of wood products in the world today are completely or partially bonded together using a variety of adhesives. Adhesive bonding offers many advantages over other joining methods for wood components, and there has been a great deal of R& D activity in devising new wood adhesives or improving the existing ones. The modern mantra in all industrial sectors is: "think green, go green," which has attracted much attention in the wood adhesive industry. Therefore, there is also a lot of research activity in synthesizing environmentally benign and human-friendly wood adhesives. This book is divided into four parts: Part 1: Fundamental Adhesion Aspects in Wood Bonding; Part 2: Synthetic Adhesives; Part 3: Environment-friendly adhesives; and Part 4: Wood Welding and General Paper. It addresses many different types of wood adhesives, as well as bonding (welding) of wood components without adhesives, a more recent development. The information contained in this book is valuable for individuals engaged in all aspects of wood adhesion and adhesives and, hopefully, will inspire new ideas in wood adhesives, a topic of vital industrial importance.
"All it Is, It's a Carnival"
Author: Mária Németh Lenke
Publisher:
ISBN:
Category : American drama
Languages : en
Pages : 164
Book Description
Publisher:
ISBN:
Category : American drama
Languages : en
Pages : 164
Book Description
Sea Plants
Author:
Publisher: Elsevier
ISBN: 012408107X
Category : Science
Languages : en
Pages : 593
Book Description
Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. The series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume, number 71, features reviews on sea plants. Its chapters cover topics such as the role of algae in sustainability; the status of kelp exploitation and marine agronomy; potential applications for enzymatic recovery of metabolites from seaweeds; and many more. - Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences - Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology - Volume features reviews on sea plants
Publisher: Elsevier
ISBN: 012408107X
Category : Science
Languages : en
Pages : 593
Book Description
Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. The series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume, number 71, features reviews on sea plants. Its chapters cover topics such as the role of algae in sustainability; the status of kelp exploitation and marine agronomy; potential applications for enzymatic recovery of metabolites from seaweeds; and many more. - Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences - Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology - Volume features reviews on sea plants
Advances in Polymer Science
Author:
Publisher:
ISBN: 9780387134833
Category : Membranes (Biology)
Languages : en
Pages : 165
Book Description
Publisher:
ISBN: 9780387134833
Category : Membranes (Biology)
Languages : en
Pages : 165
Book Description