Virus-Induced Immunosuppression

Virus-Induced Immunosuppression PDF Author: Steven Specter
Publisher: Springer Science & Business Media
ISBN: 1468455834
Category : Medical
Languages : en
Pages : 486

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Book Description
It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.

Virus-Induced Immunosuppression

Virus-Induced Immunosuppression PDF Author: Steven Specter
Publisher: Springer Science & Business Media
ISBN: 1468455834
Category : Medical
Languages : en
Pages : 486

Get Book Here

Book Description
It is now widely acknowledged that at the beginning of this century Claude von Pirquet first pointed out that a viral disease, i. e. , measles, resulted in an anergy or depression of preexisting immune response, namely, delayed continuous hypersensitivity to PPD derived from Mycobacterium tuberculosis. Thereafter ob servations that viral infections may result in immunosuppression have been recorded by many clinicians and infectious disease investigators for six or seven decades. Nevertheless, despite sporadic reports that infectious diseases caused by viruses may result in either transient or prolonged immunodepression, investigation of this phenomenon languished until the mid-1960s, when it was pointed out that a number of experimental retroviral infections of mice with tumor viruses may result in marked immunosuppression. However, it was not until the recognition of the new epidemic of acquired immunodeficiency syn drome (AIDS) caused by the human immunodeficiency virus and related vi ruses that acquired immunodeficiencies associated with virus infection became general knowledge among biomedical investigators as well as the lay public. A number of reviews published during the past decade or so pointed out that numerous viruses may affect humoral and cellular immune responses. Furthermore, expanding knowledge about the nature and mechanisms of both humoral and cellular immunity and pathogenesis of viral infections has pro vided clinical and experimental models for investigating in depth how and why viruses of man and animals profoundly affect immune responses.

Names for the Sea

Names for the Sea PDF Author: Sarah Moss
Publisher: Catapult
ISBN: 1619022176
Category : Biography & Autobiography
Languages : en
Pages : 226

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Book Description
A beautifully written memoir of a family’s year living in Reykjavik, Iceland that “captures the fierce beauty of the Arctic landscape”—from the acclaimed author of Ghost Wall (Booklist). Sarah Moss had a childhood dream of moving to Iceland, sustained by a wild summer there when she was nineteen. In 2009, she saw an advertisement for a job at the University of Iceland and applied on a whim, despite having two young children and a comfortable life in Kent, England. The resulting adventure was shaped by Iceland’s economic collapse, which halved the value of her salary; by the eruption of the volcano Eyjafjallajokull; and by a collection of new friends, including a poet who saw the only bombs fall on Iceland in 1943; a woman who speaks to elves; and a chef who guided Sarah’s family around the intricacies of Icelandic cuisine. Moss explored hillsides of boiling mud and volcanic craters and learned to drive like an Icelander on the unsurfaced roads that link remote farms and fishing villages in the far north. She watched the northern lights and the comings and goings of migratory birds, and as the weeks and months went by, she and her family learned new ways to live. Names for the Sea is her compelling and very funny account of living in a country poised on the edge of Europe, where modernization clashes with living folklore.

The Underside of Joy

The Underside of Joy PDF Author: Sere Prince Halverson
Publisher: Penguin
ISBN: 1101554339
Category : Fiction
Languages : en
Pages : 242

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Book Description
Set against the backdrop of Redwood forests and shimmering vineyards, Seré Prince Halverson's compelling debut tells the story of two women, bound by an unspeakable loss, who each claims to be the mother of the same two children. To Ella Beene, happiness means living in the northern California river town of Elbow with her husband, Joe, and his two young children. Yet one summer day Joe breaks his own rule-never turn your back on the ocean-and a sleeper wave strikes him down, drowning not only the man but his many secrets. For three years, Ella has been the only mother the kids have known and has believed that their biological mother, Paige, abandoned them. But when Paige shows up at the funeral, intent on reclaiming the children, Ella soon realizes there may be more to Paige and Joe's story. "Ella's the best thing that's happened to this family," say her close-knit Italian-American in-laws, for generations the proprietors of a local market. But their devotion quickly falters when the custody fight between mother and stepmother urgently and powerfully collides with Ella's quest for truth. The Underside of Joy is not a fairy-tale version of stepmotherhood pitting good Ella against evil Paige, but an exploration of the complex relationship of two mothers. Their conflict uncovers a map of scars-both physical and emotional-to the families' deeply buried tragedies, including Italian internment camps during World War II and postpartum psychosis. Weaving a rich fictional tapestry abundantly alive with the glorious natural beauty of the novel's setting, Halverson is a captivating guide through the flora and fauna of human emotion-grief and anger, shame and forgiveness, happiness and its shadow complement . . . the underside of joy.

Public Sector Reforms in Pakistan

Public Sector Reforms in Pakistan PDF Author: Abiha Zahra
Publisher: Springer Nature
ISBN: 3030968251
Category : Political Science
Languages : en
Pages : 393

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Book Description
This book provides a research-based analysis of public sector reforms in Pakistan. It offers a broad overview of reforms at different levels of government – including federal, provincial and local – and examines decentralization and devolution reforms in various policy sectors. It also reflects on market-oriented reforms and the steps taken to involve the private sector to build a better-governed public sector, and explores new trends in the public sector in the areas of digitalisation and disaster management. Bringing together young researchers, academics, and practitioners, the book sets a new milestone in the movement towards context-specific reform studies in both academia and the professional practice of public administration, particularly in South Asia.

The Indian Heritage of America

The Indian Heritage of America PDF Author: Alvin M. Josephy
Publisher: Houghton Mifflin Harcourt
ISBN: 9780395573204
Category : History
Languages : en
Pages : 468

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Book Description
From the prehistoric peoples who inhabited the Americas at the end of the last Ice Age to the American Indian of the 20th century, this book encompasses the whole historical and cultural range of Indian life in Corth, Central, and South America. 32 pages of black-and-white photographs.

State and Local Government Purchasing

State and Local Government Purchasing PDF Author: National Association of State Purchasing Officials (U.S.)
Publisher:
ISBN: 9780872920125
Category : Government purchasing
Languages : en
Pages : 324

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Book Description


Adaptive Radiation Therapy

Adaptive Radiation Therapy PDF Author: X. Allen Li
Publisher: CRC Press
ISBN: 1439816352
Category : Medical
Languages : en
Pages : 404

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Book Description
Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging an

The Rucker Family Genealogy, with Their Ancestors, Descendants and Connections

The Rucker Family Genealogy, with Their Ancestors, Descendants and Connections PDF Author: Sudie Rucker Wood
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description


The Land of Open Graves

The Land of Open Graves PDF Author: Jason De Leon
Publisher: Univ of California Press
ISBN: 0520958683
Category : Social Science
Languages : en
Pages : 378

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Book Description
In this gripping and provocative “ethnography of death,” anthropologist and MacArthur "Genius" Fellow Jason De León sheds light on one of the most pressing political issues of our time—the human consequences of US immigration and border policy. The Land of Open Graves reveals the suffering and deaths that occur daily in the Sonoran Desert of Arizona as thousands of undocumented migrants attempt to cross the border from Mexico into the United States. Drawing on the four major fields of anthropology, De León uses an innovative combination of ethnography, archaeology, linguistics, and forensic science to produce a scathing critique of “Prevention through Deterrence,” the federal border enforcement policy that encourages migrants to cross in areas characterized by extreme environmental conditions and high risk of death. For two decades, systematic violence has failed to deter border crossers while successfully turning the rugged terrain of southern Arizona into a killing field. Featuring stark photography by Michael Wells, this book examines the weaponization of natural terrain as a border wall: first-person stories from survivors underscore this fundamental threat to human rights, and the very lives, of non-citizens as they are subjected to the most insidious and intangible form of American policing as institutional violence. In harrowing detail, De León chronicles the journeys of people who have made dozens of attempts to cross the border and uncovers the stories of the objects and bodies left behind in the desert. The Land of Open Graves will spark debate and controversy.

The Baldwin genealogy from 1500 to 1881

The Baldwin genealogy from 1500 to 1881 PDF Author: C.C. Baldwin
Publisher: Рипол Классик
ISBN: 5874721363
Category : History
Languages : en
Pages : 989

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Book Description