Author: Francesco Saverio De Ponte
Publisher: Springer Science & Business Media
ISBN: 8847020832
Category : Medical
Languages : en
Pages : 186
Get Book Here
Book Description
During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.
Author: Sven Otto
Publisher: Springer
ISBN: 3662437333
Category : Medical
Languages : en
Pages : 216
Get Book Here
Book Description
Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.
Author: Salvatore L. Ruggiero
Publisher: Elsevier Health Sciences
ISBN: 0323413471
Category : Medical
Languages : en
Pages : 113
Get Book Here
Book Description
Editor Salvatore Ruggiero, DMD, MD and authors review the Diagnosis, Management and Prevention of Medication-related Osteonecrosis of the Jaw. Articles will include: Osteoporosis and bone modulation therapies: indications and outcomes; Antiresorptive therapies for the treatment of malignant osteolytic bone disease; Clinical presentation and staging of antiresorptive agent-induced osteonecrosis of the jaw; Epidemiology and risk factors of antiresorptive agent-induced osteonecrosis of the jaw; Basic science research of antiresorptive agent-induced osteonecrosis of the jaw: an update; Pathophysiology of antiresorptive agent-induced osteonecrosis of the jaw: what we know and what we don’t know; The genetics of osteonecrosis of the jaw; Preventive strategies for patients at risk of antiresorptive agent-induced osteonecrosis of the jaw; Non-operative and operative therapies for treatment of antiresorptive agent-induced osteonecrosis of the jaw; The role of anti-angiogenic therapy in the development of osteonecrosis of the jaw; Antiresorptive therapies: what they are and how do they work, and more!
Author: Robert E. Marx
Publisher: Quintessence Publishing (IL)
ISBN:
Category : Medical
Languages : en
Pages : 172
Get Book Here
Book Description
Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws deals with dentistry.
Author: Luchetti Cesar
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Clinical Management and Successful Treatment of Bisphosphonates Related Osteonecrosis of the JawBackground Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious oral complication of bisphosphonate treatment involving the exposure of necrotic maxillary or mandibular bone. BRONJ is associated with pain, paresthesia, and oral dysfunction generating an impairment of the quality of life. Treatment of this complication remains difficult. Surgery is normally contraindicated and the most useful action is prevention.Aim/Hypothesis To develop a conservative and active approach to treat BRONJ in patients receiving intravenous bisphosphonates.Materials and Methods 46 patients over last 12 years, who received an active, still conservative treatment, were analyzed. In each case, the protocol was to manipulate the bone exposure by gently trying to loosen it three times a week. During each visit, we carefully irrigated and cleansed the area apical to the bony sequestrum using 5cc of chlorhexidine 0.12 % followed by 5cc of 3% hydrogen peroxide. Detritus were eliminated by means of a hand brush. The aim is that soft tissue healing begin to occur below the bone exposure before the final removal of the sequestrum. Home care included local rinses with chlorhexidine 0.12 % 3 times a day and 3% hydrogen peroxide once a day, and the use of a soft brush to clean the exposed bone.Antibiotics were used just when an active infection was present. Antibiotics of choice were mainly Ciprofloxacin and Metronidazole, and in some cases Azitromicin, always based in the results of an antibiogram.After some time, ranging from a few weeks to 4 months, sequestrums were loose enough to attempt removal. We successfully removed the sequestrums with rongeurs and used rotary instruments to eliminate remaining bony spicules to get a smooth bone surface and facilitate healing.Results In all cases, after the procedure was done, the soft tissue healed after around one month. No new bone exposure were observed.31 cases received no more treatment, 14 cases were delivered removable prosthesis, and in one case, dental implants were placed 7 years after the BRONJ treatment, and they were successful after 3 attempts. The last case was performed due to patient request and based in favorable values of Serum C-terminal telopeptide (CTX) test.Conclusions and Clinical implications The latest literature, and also this study, supports the concept that BRONJ may be successfully treated. The approach described here, especially regarding bone exposure management, could minimize necessary surgical corrections upon removal of the sequestrum.The resolution of these cases does not ensure that every case can be resolved in the same way or with the same results, but shows us that there is a real possibility to treat this pathology with success. Each case must be evaluated individually and primary approaches must always be conservative and focused on prevention.
Author: Kenneth Fleisher
Publisher: Thieme
ISBN: 313258228X
Category : Medical
Languages : en
Pages : 125
Get Book Here
Book Description
A collaboration between some of the leading international experts in the field, AOCMF proudly presents Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research, which unravels the many biologic processes and risk factors associated with this debilitating condition. With its unknown pathophysiology, lack of established management regimens, and because of the millions of patients currently taking antiresorptive agents, this important book on ARONJ has been produced to provide the latest in contemporary evidence and insight. The book's key features include: Detailed analysis of the historical definitions, classifications, and clinical features of ARONJ Review of the risk factors and treatment options currently available, and why the jaw bone is predominantly affected Discussion on the use of large and small animals in modelling. With dozens of clinical images to help illustrate the impact of this condition on real patients, Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research is an excellent resource for anyone involved or interested in this important medical field.
Author: Jodi Shannon
Publisher:
ISBN:
Category : Diphosphonates
Languages : en
Pages : 88
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Diphosphonates
Languages : en
Pages : 87
Get Book Here
Book Description
"'Bisphosphonates and Osteonecrosis of the Jaw' stems from a conference held at the New York Academy of Sciences organized by John P. Bilezikian and John T. Grbic (Columbia University College of Physicians and Surgeons, New York, New York), G. David Roodman (University of Pittsburgh Hillman Cancer Center, Pittsburgh, Pennsylvania), and Catherine H. Van Poznak (University of Michigan, Ann Arbor, Michigan). Bisphosphonates work by inhibiting osteoclast action. Millions of people with osteoporosis and other bone diseases have been treated with bisphosphonates. These drugs are also used in chemotherapy to prevent bone pain and bone loss in advanced cancer that has metastasized. In the past few years there have been reports that patients on bisphosphonates have been developing a condition termed osteonecrosis of the jaw (ONJ). The papers in this volume discuss various aspects of ONJ and strategies to move the research on bisphosphonates and ONJ forward, as well as evaluate the risk of ONJ relative to the beneficial effects of bisphosphonates."--Academy website.
Author: Krishnamurthy Bonanthaya
Publisher: Springer Nature
ISBN: 9811513465
Category : Face
Languages : en
Pages : 1965
Get Book Here
Book Description
This is an open access book with CC BY 4.0 license. This comprehensive open access textbook provides a comprehensive coverage of principles and practice of oral and maxillofacial surgery. With a range of topics starting from routine dentoalveolar surgery to advanced and complex surgical procedures, this volume is a meaningful combination of text and illustrations including clinical photos, radiographs, and videos. It provides guidance on evidence-based practices in context to existing protocols, guidelines and recommendations to help readers deal with most clinical scenarios in their daily surgical work. This multidisciplinary textbook is meant for postgraduate trainees, young practicing oral surgeons and experienced clinicians, as well as those preparing for university and board certification exams. It also aids in decision-making, the implementation of treatment plans and the management of complications that may arise. This book is an initiative of Association of Oral and Maxillofacial Surgeons of India (AOMSI) to its commitment to academic medicine. As part of this commitment, this textbook is in open access to help ensure widest possible dissemination to readers across the world. ; Open access Unique presentation with contents divided into color-coded core competency gradations Covers all aspects of oral and maxillofacial surgery Supplemented with videos of all commonly carried out procedures as operative video Every chapter or topic concludes with "future perspective" and addresses cutting edge advances in each area Every topic has a pull out box that provides the most relevant systematic reviews/ key articles to every topic.
Author: Eric S. Orwoll
Publisher: Academic Press
ISBN: 0080923461
Category : Medical
Languages : en
Pages : 764
Get Book Here
Book Description
Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy There is no book on the market that covers osteoporosis in men as comprehensively as this book
