Biology of Aminoacyl-tRNA Synthetases PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Biology of Aminoacyl-tRNA Synthetases PDF full book. Access full book title Biology of Aminoacyl-tRNA Synthetases by . Download full books in PDF and EPUB format.
Author:
Publisher: Academic Press
ISBN: 0128202610
Category : Science
Languages : en
Pages : 440
Get Book Here
Book Description
Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
Author:
Publisher: Academic Press
ISBN: 0128202610
Category : Science
Languages : en
Pages : 440
Get Book Here
Book Description
Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
Author: Sunghoon Kim
Publisher: Springer
ISBN: 9401787018
Category : Science
Languages : en
Pages : 355
Get Book Here
Book Description
This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
Author: Michael Ibba
Publisher: CRC Press
ISBN: 9781587061899
Category : Science
Languages : en
Pages : 0
Get Book Here
Book Description
By virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Anders Liljas
Publisher: World Scientific
ISBN: 9814531804
Category : Science
Languages : en
Pages : 494
Get Book Here
Book Description
This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases.Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.
Author: Walt Ream
Publisher: Elsevier
ISBN: 0080479510
Category : Science
Languages : en
Pages : 322
Get Book Here
Book Description
Molecular Microbiology Laboratory is designed to teach molecular biology techniques to upper level undergraduates majoring in the life sciences. An extremely detailed lab preparation manual for teaching assistants accompanies the lab book and contains a general discussion of scientific writing and critical reading, as well as detailed instructions for preparation and peer review of lab reports. Each experimental unit is accompanied by a number of additional writing exercises based upon primary journal articles. The studies in these articles employ the techniques that the students are learning in the lab exercises, which reinforces their understanding of the material. These are techniques that students in any biological science will need to know, making this manual applicable to any life science curriculum. Key Features * Not a typical cookbook lab exercise, offers students the excitement and intellectual challenge of characterizing true unknowns. They could discover a new species! * Success rate greater than 85% for the entire experiment, even with very inexperienced students. * The ONLY manual that incorporates writing exercises into the curriculum. * Co-authored by Dr. Janine Trempy, one of four senior editors of the Journal of Microbiology Education, published by the American Society for Microbiology.
Author: Koji Tamura
Publisher: MDPI
ISBN: 3038427691
Category : Science
Languages : en
Pages : 203
Get Book Here
Book Description
This book is a printed edition of the Special Issue "The Origin and Evolution of the Genetic Code: 100th Anniversary Year of the Birth of Francis Crick" that was published in Life
Author: Biman Bagchi
Publisher: Cambridge University Press
ISBN: 1107037298
Category : Medical
Languages : en
Pages : 383
Get Book Here
Book Description
A unified overview of the dynamical properties of water and its unique and diverse role in biological and chemical processes.
Author: Naohiro Terasaka
Publisher: Springer
ISBN: 4431565175
Category : Science
Languages : en
Pages : 99
Get Book Here
Book Description
In this thesis, applications of aminoacylation ribozymes named flexizymes are described. Flexizymes have the following unique characteristics: (i) substrate RNA is recognized by two consecutive base pairs between the 3'-end of substrate RNA and the 3'-end of the flexizyme; (ii) these base pairs can be substituted with other base pairs; and (iii) various activated amino acids can be used as substrates including both canonical and noncanonical amino acids. This flexible aminoacylation of RNAs by flexizymes was used to label endogenous tRNAs to be removed, and in vitro selection using the tRNA-depleted library enabled the discovery of the novel interaction between the microRNA precursor and metabolites. Flexizymes are also used to prepare various aminoacyl-tRNAs bearing mutations at the 3'-end to engineer the translation machinery and to develop the orthogonal translation machinery. The first part of the research demonstrated that SELEX is appropriate for discovering the interaction between small RNA and ligands, and suggested that more RNA motif binding to small molecules exists in small RNAs. The second part opened a door to new opportunities for in vitro synthetic biology involving the engineering of the genetic codes and translation machineries. This research also indicated the great potential of aminoacylation by flexizymes to be applied in various fields of RNA research, which is beneficial for RNA researchers.
Author: Darren John Parker
Publisher:
ISBN:
Category :
Languages : en
Pages : 203
Get Book Here
Book Description
The phenotype of a cell is a consequence of both the identity of the genes in the genome and the magnitude of their expression into proteins. While the biochemical function of many proteins has been uncovered, for most it is unclear how important native protein abundances are for cell fitness. Furthermore, linking changes in abundances with downstream effects on enzymatic output, pathway function, and ultimately cell fitness is unexplored in nearly all cases. Here I use a model enzyme family, the aminoacyl tRNA synthetases (aaRS), to explore how sensitive Bacillus subtilis are to changes in aaRS production from the molecular to phenotypic level. This culmination of protein levels, functional output, and fitness, leads to a complete “fitness landscape” for the aaRS proteins and provides a framework for future study in quantitative biology. In Chapter I, I outline the conceptual questions explored in this thesis, review the current understandings of bacterial translation and aaRS function, and note the various regulatory strategies bacteria utilize to adapt to perturbations. In Chapter II, I find that the aaRS proteins are produced to optimize the growth rate of cells despite the presence of uncharged tRNAs. These native levels are positioned near a ‘fitness cliff’ as the underlying molecular processes of tRNA charging, translation, and regulation, are sensitive to reductions but not increases in synthetase production. In Chapter III, I complete the characterization of the aaRS fitness landscapes by exploring the source of the fitness defects of aaRS overproduction. In Chapter IV, I present a novel protocol for RNA-seq library preparation to reduce the cost and time associated with generating transcriptomic datasets. In Chapter V, using the aforementioned protocol, I characterize the transcriptomes of over 70 strains within the Escherichia coli single gene knockout collection. With the help of a colleague we find that strong selective pressures to induce genes involved in motility leads to a large amount of transcriptome heterogeneity within the collection. Finally, in Chapter VI, I discuss the results of my work, setting up future directions within the context of gene expression, bacterial physiology, and beyond.
