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Author: Roland Vetter
Publisher: Springer Science & Business Media
ISBN: 1461312892
Category : Science
Languages : en
Pages : 334
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Book Description
This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews dedi cated, on the occasion of the 40th anniversary of the inauguration of the Heart Research Group in Berlin-Buch that today forms a part there of the Max Delbriick Center for Molecular Medicine, to Professor Albert Wollenberger, founder of the Heart Research Group and for 21 years its head. The papers in this issue are written by researchers working in the field of cardiovascular research who together with Albert Wollenberger share the belief that an integrative application of advances in molecular and cellular biology will lead to new concepts for treatment and prevention of cardiovascular diseases. We hope that this special will serve as a good source of information in this regard. We wish to thank all of the contributors for their help and cooperation. We also wish to thank Mrs. Verona Kuhle for her secretarial help. We are grateful to Dr. Naranjan S. Dhalla, Editor-in-Chief of Molecular and Cellular Biochemistry for his interest and encouragement, and for agreeing to publish this issue in honor of Albert Wollenberger. ROLAND VETTER and ERNST -GEORG KRAUSE Max Delbriick Center for Molecular Medicine, Robert-Rossle-StraBe 10, 13122 Berlin-Buch, Germany PART I CARDIAC DEVELOPMENT AND REGULATION Molecular and Cellular Biochemistry 163/164: 5-11, 1996. © 1996 Kluwer Academic Publishers.
Author: Roland Vetter
Publisher: Springer Science & Business Media
ISBN: 1461312892
Category : Science
Languages : en
Pages : 334
Get Book Here
Book Description
This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews dedi cated, on the occasion of the 40th anniversary of the inauguration of the Heart Research Group in Berlin-Buch that today forms a part there of the Max Delbriick Center for Molecular Medicine, to Professor Albert Wollenberger, founder of the Heart Research Group and for 21 years its head. The papers in this issue are written by researchers working in the field of cardiovascular research who together with Albert Wollenberger share the belief that an integrative application of advances in molecular and cellular biology will lead to new concepts for treatment and prevention of cardiovascular diseases. We hope that this special will serve as a good source of information in this regard. We wish to thank all of the contributors for their help and cooperation. We also wish to thank Mrs. Verona Kuhle for her secretarial help. We are grateful to Dr. Naranjan S. Dhalla, Editor-in-Chief of Molecular and Cellular Biochemistry for his interest and encouragement, and for agreeing to publish this issue in honor of Albert Wollenberger. ROLAND VETTER and ERNST -GEORG KRAUSE Max Delbriick Center for Molecular Medicine, Robert-Rossle-StraBe 10, 13122 Berlin-Buch, Germany PART I CARDIAC DEVELOPMENT AND REGULATION Molecular and Cellular Biochemistry 163/164: 5-11, 1996. © 1996 Kluwer Academic Publishers.
Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
ISBN: 4431683674
Category : Medical
Languages : en
Pages : 330
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Book Description
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Author: Michael Schwarzer
Publisher: Academic Press
ISBN: 0128026146
Category : Science
Languages : en
Pages : 241
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Book Description
The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. - Provides a quick and comprehensive introduction into cardiac metabolism - Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs - Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function - Includes historical perspectives that reference important investigators that have contributed to the development of the field
Author: Monte Willis
Publisher: Academic Press
ISBN: 0124055257
Category : Medical
Languages : en
Pages : 339
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Book Description
Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Author: Roland N. Pittman
Publisher: Biota Publishing
ISBN: 1615047212
Category : Medical
Languages : en
Pages : 117
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Book Description
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Author: Gary D. Lopaschuk
Publisher: Springer
ISBN: 1493912275
Category : Science
Languages : en
Pages : 301
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Book Description
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
Author: Hiroshi Abe
Publisher: VSP
ISBN: 9789067640350
Category : Medical
Languages : en
Pages : 346
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Book Description
This book gives a consensus of views and research trends in the regulation of cardiac function and metabolism. Emphasis is given to the elucidation of fundamental concepts and principles of clinically relevant issues. The aim is that the clinician should be able to approach a particular aspect of any given problem logically, thereby gaining insights into the fundamental pathophysiological mechanism underlying diseases states. Regulation of Cardiac Function is organized within six principle areas from the molecular and cellular aspects to more clinically applied problems of heart disease. This book gives pertinent guidelines and summarizes knowledge on basic research relevant to cardiac function and metabolism in health and disease.
Author: Stanley A. Briller
Publisher: University of Pennsylvania Press
ISBN: 1512814792
Category : Science
Languages : en
Pages : 376
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Book Description
This book is a volume in the Penn Press Anniversary Collection. To mark its 125th anniversary in 2015, the University of Pennsylvania Press rereleased more than 1,100 titles from Penn Press's distinguished backlist from 1899-1999 that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas.
Author: Stephen W. Schaffer
Publisher: Springer Science & Business Media
ISBN: 0387699457
Category : Science
Languages : en
Pages : 359
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Book Description
This book is indispensable to researchers in fields as diverse as Molecular Biology and Biophysics. It covers the important role that mitochondria play in a variety of biochemical spheres. It analyses how mitochondria affect metabolic pathways, how they are active in the regulation of cytosolic constituents, and their role in initiating signal pathways. Also covered are the way mitochondria help to regulate apoptosis, and how they modulate cellular hypertrophy and proliferation. It gives an overview of the emergence of mitochondria as an important regulator of cell signaling, with a particular focus on their pathophysiology.
Author: National Heart and Lung Institute
Publisher:
ISBN:
Category : Cardiology
Languages : en
Pages : 482
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Book Description
