Behavioral Models and the Analysis of Drug Action PDF Download
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Author: Michael Y. Spiegelstein
Publisher: Elsevier Science & Technology
ISBN:
Category : Medical
Languages : en
Pages : 526
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Book Description
Author: Michael Y. Spiegelstein
Publisher: Elsevier Science & Technology
ISBN:
Category : Medical
Languages : en
Pages : 526
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Book Description
Author: Robert B. Raffa
Publisher: CRC Press
ISBN: 1498713599
Category : Science
Languages : en
Pages : 150
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Book Description
The study of drug action has benefitted greatly from the development and use of in vivo model systems. In model systems, manipulations and observations can be more rigorously controlled and screens of novel therapeutic agents can be more safely conducted.No single model system provides all of the possible advantages. At one end, mammalian models al
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309175380
Category : Medical
Languages : en
Pages : 329
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Book Description
Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Author: Paul Willner
Publisher: Cambridge University Press
ISBN: 9780521391924
Category : Medical
Languages : en
Pages : 564
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Book Description
Behavioural models in psychopharmacology are used for different purposes. The main concern of industrial psychopharmacologists is specifically to develop new and improved drugs for the treatment of mental disorders, while basic scientists use animal models to investigate the underlying nature of such conditions. The important distinction between these different perspectives is made explicit for the first time in this book. By considering such conditions as anxiety, depression, mania and schizophrenia, feeding disorders, dementia, and drug dependence, this book provides a comprehensive and critical review of the adequacy of the behavioural procedures used by psychopharmacologists to model psychiatric disorders. Graduate students and research workers in pscyhopharmacology, from both academic and industrial spheres, as well as clinicians, will find this book of considerable interest.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1712
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Leslie Iversen
Publisher: Springer Science & Business Media
ISBN: 146131819X
Category : Medical
Languages : en
Pages : 652
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Book Description
Volumes 7 and 8 of the Handbook were published in 1977. In Volume 7 methods for studying unconditioned and conditioned behavior were reviewed. Attention was given to both ethological methods and operant conditioning techniques as applied to some selected aspects of behavior. Genetic, developmental, and environmental factors influencing behavior were also discussed. In Volume 8, neurotransmitter systems, and in par ticular brain circuits, were discussed in relation to behavior and to the effects of psychoactive drugs on behavior. The coverage was not exhaus tive because of space limitations. The topics selected for review were, at the time, the focus of considerable experimental effort; they included homeostasis-motivated behaviors: sleep, locomotion, feeding, drinking, and sexual behavior. Brain dopamine systems were therefore discussed in depth, since they were already known to be centrally involved in motivated behaviors. Learning mechanisms and emotion were reviewed in the remaining chapters. In 1984 we initiated an update of behavioral pharmacology to review areas of progress within the same scope as the earlier volumes. This update continues in Volume 19. Among the contributions are several that represent important advances in analyzing behavior and the use of more sophisticated methods to define the effect of drugs on particular aspects of behavior. The chapters by Blundell on feeding and Miczek on aggres sion illustrate the sophistication of modern ethopharmacology.
Author:
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 696
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Book Description
Author: C. F. Lowe
Publisher: Taylor & Francis
ISBN: 100064913X
Category : Psychology
Languages : en
Pages : 308
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Book Description
Originally published in 1985, Behaviour Analysis and Contemporary Psychology presents chapters from the first European Meeting on the Experimental Analysis of Behaviour. The book is divided into six parts and provides a useful account of issues and work in behaviour analysis by both European and North American contributors at the time. The first part provides an introduction, with following parts looking at behaviourist and ethological approaches; determinants of human operant behaviour; fundamental research and behaviour modification; recent developments in the behavioural analysis of drug effects; ending with an overview of contemporary behaviourism.
Author: Li Di
Publisher: Elsevier
ISBN: 0080557619
Category : Science
Languages : en
Pages : 549
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Book Description
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Author: T. Thompson
Publisher: Psychology Press
ISBN: 1317768078
Category : Psychology
Languages : en
Pages : 394
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Book Description
First published in 1987. Advances in Behavioral Pharmacology has broadened its scope in an attempt to provide a better understanding of behavioral actions of drugs and their applied implications. Each volume will be increasingly thematic and successive volumes will cover a wider range of issues. Some publications in this series, such as the present volume 6, Neurobehavioral Pharmacology, will primarily explore relations between neurochemistry and related areas of neurobiology and behavioral pharmacology.
