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Author: Marco Scutari
Publisher: CRC Press
ISBN: 1000410382
Category : Computers
Languages : en
Pages : 275
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Book Description
Explains the material step-by-step starting from meaningful examples Steps detailed with R code in the spirit of reproducible research Real world data analyses from a Science paper reproduced and explained in detail Examples span a variety of fields across social and life sciences Overview of available software in and outside R
Author: Marco Scutari
Publisher: CRC Press
ISBN: 1000410382
Category : Computers
Languages : en
Pages : 275
Get Book Here
Book Description
Explains the material step-by-step starting from meaningful examples Steps detailed with R code in the spirit of reproducible research Real world data analyses from a Science paper reproduced and explained in detail Examples span a variety of fields across social and life sciences Overview of available software in and outside R
Author: Christine Sinoquet
Publisher: OUP Oxford
ISBN: 0191019208
Category : Science
Languages : en
Pages : 415
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Book Description
Nowadays bioinformaticians and geneticists are faced with myriad high-throughput data usually presenting the characteristics of uncertainty, high dimensionality and large complexity. These data will only allow insights into this wealth of so-called 'omics' data if represented by flexible and scalable models, prior to any further analysis. At the interface between statistics and machine learning, probabilistic graphical models (PGMs) represent a powerful formalism to discover complex networks of relations. These models are also amenable to incorporating a priori biological information. Network reconstruction from gene expression data represents perhaps the most emblematic area of research where PGMs have been successfully applied. However these models have also created renewed interest in genetics in the broad sense, in particular regarding association genetics, causality discovery, prediction of outcomes, detection of copy number variations, and epigenetics. This book provides an overview of the applications of PGMs to genetics, genomics and postgenomics to meet this increased interest. A salient feature of bioinformatics, interdisciplinarity, reaches its limit when an intricate cooperation between domain specialists is requested. Currently, few people are specialists in the design of advanced methods using probabilistic graphical models for postgenomics or genetics. This book deciphers such models so that their perceived difficulty no longer hinders their use and focuses on fifteen illustrations showing the mechanisms behind the models. Probabilistic Graphical Models for Genetics, Genomics and Postgenomics covers six main themes: (1) Gene network inference (2) Causality discovery (3) Association genetics (4) Epigenetics (5) Detection of copy number variations (6) Prediction of outcomes from high-dimensional genomic data. Written by leading international experts, this is a collection of the most advanced work at the crossroads of probabilistic graphical models and genetics, genomics, and postgenomics. The self-contained chapters provide an enlightened account of the pros and cons of applying these powerful techniques.
Author: Olivier Pourret
Publisher: John Wiley & Sons
ISBN: 9780470994542
Category : Mathematics
Languages : en
Pages : 446
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Book Description
Bayesian Networks, the result of the convergence of artificial intelligence with statistics, are growing in popularity. Their versatility and modelling power is now employed across a variety of fields for the purposes of analysis, simulation, prediction and diagnosis. This book provides a general introduction to Bayesian networks, defining and illustrating the basic concepts with pedagogical examples and twenty real-life case studies drawn from a range of fields including medicine, computing, natural sciences and engineering. Designed to help analysts, engineers, scientists and professionals taking part in complex decision processes to successfully implement Bayesian networks, this book equips readers with proven methods to generate, calibrate, evaluate and validate Bayesian networks. The book: Provides the tools to overcome common practical challenges such as the treatment of missing input data, interaction with experts and decision makers, determination of the optimal granularity and size of the model. Highlights the strengths of Bayesian networks whilst also presenting a discussion of their limitations. Compares Bayesian networks with other modelling techniques such as neural networks, fuzzy logic and fault trees. Describes, for ease of comparison, the main features of the major Bayesian network software packages: Netica, Hugin, Elvira and Discoverer, from the point of view of the user. Offers a historical perspective on the subject and analyses future directions for research. Written by leading experts with practical experience of applying Bayesian networks in finance, banking, medicine, robotics, civil engineering, geology, geography, genetics, forensic science, ecology, and industry, the book has much to offer both practitioners and researchers involved in statistical analysis or modelling in any of these fields.
Author: Ilya Shmulevich
Publisher: SIAM
ISBN: 0898716926
Category : Mathematics
Languages : en
Pages : 276
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Book Description
The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.
Author: Radhakrishnan Nagarajan
Publisher: Springer Science & Business Media
ISBN: 1461464463
Category : Computers
Languages : en
Pages : 168
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Book Description
Bayesian Networks in R with Applications in Systems Biology is unique as it introduces the reader to the essential concepts in Bayesian network modeling and inference in conjunction with examples in the open-source statistical environment R. The level of sophistication is also gradually increased across the chapters with exercises and solutions for enhanced understanding for hands-on experimentation of the theory and concepts. The application focuses on systems biology with emphasis on modeling pathways and signaling mechanisms from high-throughput molecular data. Bayesian networks have proven to be especially useful abstractions in this regard. Their usefulness is especially exemplified by their ability to discover new associations in addition to validating known ones across the molecules of interest. It is also expected that the prevalence of publicly available high-throughput biological data sets may encourage the audience to explore investigating novel paradigms using the approaches presented in the book.
Author: Giovanni Petris
Publisher: Springer Science & Business Media
ISBN: 0387772383
Category : Mathematics
Languages : en
Pages : 258
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Book Description
State space models have gained tremendous popularity in recent years in as disparate fields as engineering, economics, genetics and ecology. After a detailed introduction to general state space models, this book focuses on dynamic linear models, emphasizing their Bayesian analysis. Whenever possible it is shown how to compute estimates and forecasts in closed form; for more complex models, simulation techniques are used. A final chapter covers modern sequential Monte Carlo algorithms. The book illustrates all the fundamental steps needed to use dynamic linear models in practice, using R. Many detailed examples based on real data sets are provided to show how to set up a specific model, estimate its parameters, and use it for forecasting. All the code used in the book is available online. No prior knowledge of Bayesian statistics or time series analysis is required, although familiarity with basic statistics and R is assumed.
Author: Sylvia Fruhwirth-Schnatter
Publisher: CRC Press
ISBN: 0429508867
Category : Computers
Languages : en
Pages : 489
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Book Description
Mixture models have been around for over 150 years, and they are found in many branches of statistical modelling, as a versatile and multifaceted tool. They can be applied to a wide range of data: univariate or multivariate, continuous or categorical, cross-sectional, time series, networks, and much more. Mixture analysis is a very active research topic in statistics and machine learning, with new developments in methodology and applications taking place all the time. The Handbook of Mixture Analysis is a very timely publication, presenting a broad overview of the methods and applications of this important field of research. It covers a wide array of topics, including the EM algorithm, Bayesian mixture models, model-based clustering, high-dimensional data, hidden Markov models, and applications in finance, genomics, and astronomy. Features: Provides a comprehensive overview of the methods and applications of mixture modelling and analysis Divided into three parts: Foundations and Methods; Mixture Modelling and Extensions; and Selected Applications Contains many worked examples using real data, together with computational implementation, to illustrate the methods described Includes contributions from the leading researchers in the field The Handbook of Mixture Analysis is targeted at graduate students and young researchers new to the field. It will also be an important reference for anyone working in this field, whether they are developing new methodology, or applying the models to real scientific problems.
Author: Ming-Hui Chen
Publisher: Springer Science & Business Media
ISBN: 1441969446
Category : Mathematics
Languages : en
Pages : 631
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Book Description
Research in Bayesian analysis and statistical decision theory is rapidly expanding and diversifying, making it increasingly more difficult for any single researcher to stay up to date on all current research frontiers. This book provides a review of current research challenges and opportunities. While the book can not exhaustively cover all current research areas, it does include some exemplary discussion of most research frontiers. Topics include objective Bayesian inference, shrinkage estimation and other decision based estimation, model selection and testing, nonparametric Bayes, the interface of Bayesian and frequentist inference, data mining and machine learning, methods for categorical and spatio-temporal data analysis and posterior simulation methods. Several major application areas are covered: computer models, Bayesian clinical trial design, epidemiology, phylogenetics, bioinformatics, climate modeling and applications in political science, finance and marketing. As a review of current research in Bayesian analysis the book presents a balance between theory and applications. The lack of a clear demarcation between theoretical and applied research is a reflection of the highly interdisciplinary and often applied nature of research in Bayesian statistics. The book is intended as an update for researchers in Bayesian statistics, including non-statisticians who make use of Bayesian inference to address substantive research questions in other fields. It would also be useful for graduate students and research scholars in statistics or biostatistics who wish to acquaint themselves with current research frontiers.
Author: Andrew Gelman
Publisher: CRC Press
ISBN: 1439840954
Category : Mathematics
Languages : en
Pages : 677
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Book Description
Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.
Author: Syed Ejaz Ahmed
Publisher: CRC Press
ISBN: 1000876659
Category : Business & Economics
Languages : en
Pages : 409
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Book Description
This book presents some post-estimation and predictions strategies for the host of useful statistical models with applications in data science. It combines statistical learning and machine learning techniques in a unique and optimal way. It is well-known that machine learning methods are subject to many issues relating to bias, and consequently the mean squared error and prediction error may explode. For this reason, we suggest shrinkage strategies to control the bias by combining a submodel selected by a penalized method with a model with many features. Further, the suggested shrinkage methodology can be successfully implemented for high dimensional data analysis. Many researchers in statistics and medical sciences work with big data. They need to analyse this data through statistical modelling. Estimating the model parameters accurately is an important part of the data analysis. This book may be a repository for developing improve estimation strategies for statisticians. This book will help researchers and practitioners for their teaching and advanced research, and is an excellent textbook for advanced undergraduate and graduate courses involving shrinkage, statistical, and machine learning. The book succinctly reveals the bias inherited in machine learning method and successfully provides tools, tricks and tips to deal with the bias issue. Expertly sheds light on the fundamental reasoning for model selection and post estimation using shrinkage and related strategies. This presentation is fundamental, because shrinkage and other methods appropriate for model selection and estimation problems and there is a growing interest in this area to fill the gap between competitive strategies. Application of these strategies to real life data set from many walks of life. Analytical results are fully corroborated by numerical work and numerous worked examples are included in each chapter with numerous graphs for data visualization. The presentation and style of the book clearly makes it accessible to a broad audience. It offers rich, concise expositions of each strategy and clearly describes how to use each estimation strategy for the problem at hand. This book emphasizes that statistics/statisticians can play a dominant role in solving Big Data problems, and will put them on the precipice of scientific discovery. The book contributes novel methodologies for HDDA and will open a door for continued research in this hot area. The practical impact of the proposed work stems from wide applications. The developed computational packages will aid in analyzing a broad range of applications in many walks of life.
