Author: Peter R. Kvietys
Publisher: Morgan & Claypool Publishers
ISBN: 1615041176
Category : Medical
Languages : en
Pages : 127
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Book Description
The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography
Author: John W. Harmon
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 440
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Jonh W. Harmon
Publisher:
ISBN:
Category :
Languages : en
Pages : 415
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Book Description
Author: Sandor Szabo
Publisher: Springer Science & Business Media
ISBN: 1461518679
Category : Medical
Languages : en
Pages : 251
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Book Description
Proceedings of a meeting held in Esterel, Quebec, Canada, September 13-15, 1989.
Author: P. Malfertheiner
Publisher: S. Karger AG (Switzerland)
ISBN: 9783318026320
Category :
Languages : en
Pages : 0
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Book Description
This special topic issue of 'Digestive Diseases' contains contributions discussing the subject in-depth. 'Digestive Diseases' is a well-respected, international peer-reviewed journal in Gastroenterology. Special topic issues are included in the subscription.
Author: A. Bennett
Publisher: Springer Science & Business Media
ISBN: 1468448536
Category : Medical
Languages : en
Pages : 358
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Book Description
Author: Gyula Mózsik
Publisher: Springer Science & Business Media
ISBN: 9401153922
Category : Medical
Languages : en
Pages : 366
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Book Description
The scientific main programmes of these series of symposia changed from time to time following the international scientific trends. The main programmes of the First Symposium were: 1. Gastric and intestinal cytoprotection; 2. Hepatoprotection; 3. Pancreatic protection. For the second one: 1. Gastrointestinal mucosal 'cytoprotection'; 2. Liver 'cytoprotection'; 3. Pancreatic 'cytoprotection'; 4. Free radicals and scavangers; 5. Computer approach to cytoprotec tion. For the third one: 1. Basic, central, peripheral and cellular mechanisms of gastrointestinaol cytoprotection; 2. Esophagal protection; 3. Gastric protection; 4. Small intestinal injury and protection; 5. Large bowel injury and protection; 6. Liver injury and protection; 7. Pancreas injury and protection. The main scientific programmes of the Fourth International Symposium on 'Cell Injury and Protection in the Gastrointestinal Tract' are: 1. General mechanisms of gastrointestinal injury and protection; 2. Cell injury and protection in the stomach; 3. Cell injury and protection in the small intestine and in the large bowel; 4. Cell injury and protection in the liver and pancreas; 5. Cell injury and protection of the premalignant status and malignant diseases in the gastrointestinal tract. The presented papers are published in this book. The abstracts of this meeting were published in Digestive Diseases and Sciences, and we record appreciation of the Editor ofthatjoumal for their publication. Some of the papers published here have appeared in Inflammopharmacology 1996;4:331-398.
Author: James Conklin
Publisher: Elsevier
ISBN: 0323151442
Category : Social Science
Languages : en
Pages : 415
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Book Description
Military Radiobiology provides an understanding of the sources and consequences of radiation exposure. Military personnel must develop a working knowledge of postexposure effects in order to determine points of intervention. The medical problems confronting military radiobiology include target damage, which causes decrements in normal performance, physiological injury, and impairments of the immunological-hematological system that lead to life-threatening infectious complications. The book begins by describing the properties of nuclear weapons, including the mechanisms by which nuclear energy is stored within the nucleus, its release, and its conversion to those forces associated with nuclear weapons. This is followed by discussions of the sources, patterns, radiological effects, and management of nuclear fallout; the biological effects of exposure to ionizing radiation released by nuclear weapons; and effects of radiation on the immune system, gastrointestinal physiology, and cardiovascular function. Subsequent chapters cover the diagnosis, triage, and treatment of radiation-associated injuries; internal contamination with radionuclides; radioprotective drugs; psychological reactions to nuclear confrontation; and the response to a nuclear weapon accident.
Author: Helmut Sinzinger
Publisher: Springer Science & Business Media
ISBN: 9780306457760
Category : Medical
Languages : en
Pages : 480
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Book Description
One hundred papers treat advances in research of the effects and uses of prostaglandins, thromboxanes, and leukotrienes in such medical fields as organ transplantation, male erectile dysfunction, amniotic fluid infection and labour, renal function, anti-inflammatory drugs, allergic and aspirin-intolerant asthma, angioplasty and heart ischemia, Alzheimer's disease, vessel wall hyperplasia, and more. Annotation copyrighted by Book News, Inc., Portland, OR
