Cheap?

Cheap? PDF Author: David Bosshart
Publisher: Kogan Page Publishers
ISBN: 9780749449933
Category : Business & Economics
Languages : en
Pages : 210

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Book Description
Challenges the idea of "cheap" and examines the long-term consequences of excessive consumer choice and low prices.

Cheap?

Cheap? PDF Author: David Bosshart
Publisher: Kogan Page Publishers
ISBN: 9780749449933
Category : Business & Economics
Languages : en
Pages : 210

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Book Description
Challenges the idea of "cheap" and examines the long-term consequences of excessive consumer choice and low prices.

Thyroid Autoimmunity

Thyroid Autoimmunity PDF Author: A. Pinchera
Publisher: Springer Science & Business Media
ISBN: 146130945X
Category : Medical
Languages : en
Pages : 579

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Book Description
In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.

Signaling Mechanisms Regulating T Cell Diversity and Function

Signaling Mechanisms Regulating T Cell Diversity and Function PDF Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258

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Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Antibody Fc

Antibody Fc PDF Author: Margaret Ackerman
Publisher: Academic Press
ISBN: 0123948185
Category : Medical
Languages : en
Pages : 376

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Book Description
Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. - Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro - Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies - Color illustrations enhance explanations of the immune system

Immunotherapy of Type 1 Diabetes

Immunotherapy of Type 1 Diabetes PDF Author: Domenico Andreani
Publisher: John Wiley & Sons
ISBN:
Category : Health & Fitness
Languages : en
Pages : 280

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Book Description
Recent national, European and international diabetes meetings have seen controversial discussions on the potential benefit and also on ethical aspects of immune intervention in patients with Type 1 diabetes or in persons with a high risk of developing the disease.

Immunopathology of Type 1 Diabetes

Immunopathology of Type 1 Diabetes PDF Author: F. Susan Wong
Publisher: Frontiers Media SA
ISBN: 2889748235
Category : Medical
Languages : en
Pages : 270

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Book Description


Type 1 Diabetes: New Insights for the Healthcare Professional: 2013 Edition

Type 1 Diabetes: New Insights for the Healthcare Professional: 2013 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 1481656333
Category : Medical
Languages : en
Pages : 293

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Book Description
Type 1 Diabetes: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Type 1 Diabetes: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Type 1 Diabetes: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Resampling-Based Multiple Testing

Resampling-Based Multiple Testing PDF Author: Peter H. Westfall
Publisher: John Wiley & Sons
ISBN: 9780471557616
Category : Mathematics
Languages : en
Pages : 382

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Book Description
Combines recent developments in resampling technology (including the bootstrap) with new methods for multiple testing that are easy to use, convenient to report and widely applicable. Software from SAS Institute is available to execute many of the methods and programming is straightforward for other applications. Explains how to summarize results using adjusted p-values which do not necessitate cumbersome table look-ups. Demonstrates how to incorporate logical constraints among hypotheses, further improving power.

Footprints of Immune Cells in the Type 1 Diabetic Pancreas

Footprints of Immune Cells in the Type 1 Diabetic Pancreas PDF Author: Teresa Rodriguez-Calvo
Publisher: Frontiers Media SA
ISBN: 2889718328
Category : Medical
Languages : en
Pages : 209

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Book Description


Autoimmune Diabetes: Molecular Mechanisms and Neoantigens

Autoimmune Diabetes: Molecular Mechanisms and Neoantigens PDF Author: Arnaud Zaldumbide
Publisher: Frontiers Media SA
ISBN: 2889746712
Category : Medical
Languages : en
Pages : 149

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Book Description