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Author: Erika Jane Starks
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: Erika Jane Starks
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Erika Jane Starks
Publisher:
ISBN:
Category :
Languages : en
Pages : 390
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Book Description
Dementia due to Alzheimer’s disease (AD) is a devastating condition characterized clinically by progressive cognitive impairment and pathologically by amyloid plaques, neurofibrillary tangles and severe atrophy. Diabetes mellitus (DM), obesity, and associated insulin resistance in middle age, are linked to a greater risk of developing dementia due to AD. Given the potential of modifying metabolic risk factors at midlife, my research explored the pathophysiological mechanisms involved in the link between insulin resistance and obesity at middle-age and AD pathology using molecular and imaging biomarkers. Specifically, my studies aimed to investigate the potential effect of metabolic risk factors on the accumulation of amyloid plaques and neurofibrillary tangles, alter brain structure and blood flow, and influence cognition in middle age. The first study was conducted to assess the effects of insulin resistance on cognitive decline over a 4-10 year period, and demonstrated that indeed, insulin resistance is associated with cognitive trajectories. The next three studies were aimed at identifying changes in AD biomarkers in CSF and brain imaging as predicted by insulin resistance, body mass index and abdominal obesity. The main findings indicate that elevated insulin resistance at midlife may affect amyloid processing as indicated by altered CSF levels, as well as acting via a tau-related mechanism, an effect that differed by APOE [epsilon]4 genotype. Given that tau in CSF is likely originating from axons, this finding was followed up by a neuroimaging study employing diffusion tensor imaging to examine the effects of insulin resistance and APOE [epsilon]4 on neural microstructure. Similar to the findings in CSF, the effects of insulin resistance on microstructure differed by APOE [epsilon]4 genotype. Finally, my studies of abdominal obesity suggest that this risk factor is not associated with amyloid or tau pathology as measured in CSF, nor microstructural changes, yet central obesity was associated with moderate effects on cerebral blood flow. In conclusion, the work presented in my thesis demonstrates a robust effect of insulin resistance on cognitive and biomarker outcomes in midlife, which may explain the increased risk of developing AD.
Author: Erika Jane Starks
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Dementia due to Alzheimer's disease (AD) is a devastating condition characterized clinically by progressive cognitive impairment and pathologically by amyloid plaques, neurofibrillary tangles and severe atrophy. Diabetes mellitus (DM), obesity, and associated insulin resistance in middle age, are linked to a greater risk of developing dementia due to AD. Given the potential of modifying metabolic risk factors at midlife, my research explored the pathophysiological mechanisms involved in the link between insulin resistance and obesity at middle-age and AD pathology using molecular and imaging biomarkers. Specifically, my studies aimed to investigate the potential effect of metabolic risk factors on the accumulation of amyloid plaques and neurofibrillary tangles, alter brain structure and blood flow, and influence cognition in middle age. The first study was conducted to assess the effects of insulin resistance on cognitive decline over a 4-10 year period, and demonstrated that indeed, insulin resistance is associated with cognitive trajectories. The next three studies were aimed at identifying changes in AD biomarkers in CSF and brain imaging as predicted by insulin resistance, body mass index and abdominal obesity. The main findings indicate that elevated insulin resistance at midlife may affect amyloid processing as indicated by altered CSF levels, as well as acting via a tau-related mechanism, an effect that differed by APOE [epsilon]4 genotype. Given that tau in CSF is likely originating from axons, this finding was followed up by a neuroimaging study employing diffusion tensor imaging to examine the effects of insulin resistance and APOE [epsilon]4 on neural microstructure. Similar to the findings in CSF, the effects of insulin resistance on microstructure differed by APOE [epsilon]4 genotype. Finally, my studies of abdominal obesity suggest that this risk factor is not associated with amyloid or tau pathology as measured in CSF, nor microstructural changes, yet central obesity was associated with moderate effects on cerebral blood flow. In conclusion, the work presented in my thesis demonstrates a robust effect of insulin resistance on cognitive and biomarker outcomes in midlife, which may explain the increased risk of developing AD.
Author: National Academies of Sciences Engineering and Medicine
Publisher:
ISBN: 9780309495035
Category :
Languages : en
Pages :
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Book Description
As the largest generation in U.S. history - the population born in the two decades immediately following World War II - enters the age of risk for cognitive impairment, growing numbers of people will experience dementia (including Alzheimer's disease and related dementias). By one estimate, nearly 14 million people in the United States will be living with dementia by 2060. Like other hardships, the experience of living with dementia can bring unexpected moments of intimacy, growth, and compassion, but these diseases also affect people's capacity to work and carry out other activities and alter their relationships with loved ones, friends, and coworkers. Those who live with and care for individuals experiencing these diseases face challenges that include physical and emotional stress, difficult changes and losses in their relationships with life partners, loss of income, and interrupted connections to other activities and friends. From a societal perspective, these diseases place substantial demands on communities and on the institutions and government entities that support people living with dementia and their families, including the health care system, the providers of direct care, and others. Nevertheless, research in the social and behavioral sciences points to possibilities for preventing or slowing the development of dementia and for substantially reducing its social and economic impacts. At the request of the National Institute on Aging of the U.S. Department of Health and Human Services, Reducing the Impact of Dementia in America assesses the contributions of research in the social and behavioral sciences and identifies a research agenda for the coming decade. This report offers a blueprint for the next decade of behavioral and social science research to reduce the negative impact of dementia for America's diverse population. Reducing the Impact of Dementia in America calls for research that addresses the causes and solutions for disparities in both developing dementia and receiving adequate treatment and support. It calls for research that sets goals meaningful not just for scientists but for people living with dementia and those who support them as well. By 2030, an estimated 8.5 million Americans will have Alzheimer's disease and many more will have other forms of dementia. Through identifying priorities social and behavioral science research and recommending ways in which they can be pursued in a coordinated fashion, Reducing the Impact of Dementia in America will help produce research that improves the lives of all those affected by dementia.
Author: Velandai Srikanth
Publisher: Academic Press
ISBN: 0128096942
Category : Medical
Languages : en
Pages : 322
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Book Description
Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications
Author: Beller Health
Publisher: Independently Published
ISBN: 9781097268511
Category :
Languages : en
Pages : 114
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Book Description
Book 9 focuses on a new dementia type, LATE, mistaken as Alzheimer's disease until now.LATE stands for Limbic-predominant age-related TDP-43 encephalopathy, the protein buildup responsible for this dementia. This book is organic, like the series, meaning we never consider our books as finished. Science evolves, which is why our books go through continuous updates. Since LATE is a new dementia classification, we expect continuous further information to emerge. Watch Amazon alerts for potential digital updates. We provide free digital copies on all paperback purchases, so everybody receives free updates.
Author: Maria Shriver
Publisher: Free Press
ISBN: 9781451639872
Category : Health & Fitness
Languages : en
Pages : 0
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Book Description
The Shriver Report: A Woman’s Nation Takes on Alzheimer’s will be the first comprehensive multi-disciplinary look at these questions at this transformational moment. The Report will digest the current trends in thinking about Alzheimer’s, examine cutting-edge medical research, look at societal impacts, and include a groundbreaking and comprehensive national poll. It will feature original photography and personal essays by men and women – some from the public arena with names you know, some from everyday America – sharing their personal struggles with the disease as patients, caregivers and family members.
Author: Richard Mayeux
Publisher: Springer Science & Business Media
ISBN: 364260076X
Category : Medical
Languages : en
Pages : 140
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Book Description
This volume contains the proceedings of the 14th Colloque Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique devoted to Alzheimer's Disease and dedicated to the epidemiological study of this dementia, a very important issue because the incidence and prevalence of Alzheimer's Disease rise exponentially with age. Epidemiological findings not only confirm dementia as a major challenge for the coming years but also contribute defining risk factors, predicting and may be preventing this disease.
Author: Helen Chiu
Publisher: Springer
ISBN: 9789811024122
Category : Medical
Languages : en
Pages : 611
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Book Description
This book consolidates current knowledge in the field and discusses psychiatric disorders among the elderly, while bridging the gap between clinical practice and the socio-cultural contexts. The book is particularly important in the face of rapidly changing conditions globally and challenges such as migration, war and violence, diminishing physical health due to ageing and their impact on the mental health of elderly. Longevity is a great gift of medical sciences and modern health care and since the benefit of longevity comes with specific mental health issues of the elderly, this book responds to the heightened need to understand and address the mental health challenges of the elderly.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309368650
Category : Medical
Languages : en
Pages : 300
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Book Description
For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.
