Application of N-donor Ligated Copper Complexes in Dioxygen Activation and the Synthesis of Copper-sulfur Clusters Relevant to Biology PDF Download
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Author: John Thomas York
Publisher:
ISBN:
Category :
Languages : en
Pages : 672
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Author: John Thomas York
Publisher:
ISBN:
Category :
Languages : en
Pages : 672
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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 980
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Author: William Jay Keown
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Biological enzymes utilize various copper-based active sites to activate dioxygen creating a variety of copper-dioxygen assemblies. These assemblies carry out highly selective and difficult oxidative transformations vital to biological life. Insight into how Nature has optimized these active sites can be gleaned by studying synthetic structural mimics and has potential to be of great benefit to the industrial design of catalysts. While the resting structures of many of these active sites are known, the nature of the active oxidants are often less well-defined. In this thesis, efforts towards the cryogenic synthesis and spectroscopic characterization of copper(III)-containing oxidants, formed directly via dioxygen activation of biomimetic copper precursors, will be discussed. This work demonstrates both the kinetic and thermodynamic accessibility of the copper(III) oxidation state under biological ligation, which challenges existing assumptions in the literature through the identification of reactive intermediates.
Author: Jalila Simaan
Publisher: World Scientific
ISBN: 9811269505
Category : Science
Languages : en
Pages : 273
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Book Description
Bioinorganic chemistry is an interdisciplinary research field which centers on metals in biology. Over the past few decades, advances in chemistry, biology as well as in spectroscopic methods have shed light on the role of copper in human pathologies and allowed the growing discovery of copper-containing biological systems. Following this trend, much effort is being constantly chanelled towards understanding these fundamental biological processes or enzymes. In addition, chemists are developing molecules to target copper or copper enzymes as therapeutic tools. On the other hand, inspired by the function of biological systems, small molecular weight complexes inspired by the active site of copper enzymes are being prepared and studied. These bioinspired complexes can function both as mechanistic tools and as functional catalysts for oxidative transformations.The seven chapters in this book, contributed by internationally recognized authors cover recent developments on these aspects illustrated by interdisciplinary fields from biology, chemistry, spectroscopy to bioinspired catalysis. It contains aspects ranging from human health issues (copper homeostasis in bacteria and the development of molecules as anticancer or antibacterial agents) to bioinspired catalysis.
Author: Kenneth D. Karlin
Publisher: John Wiley & Sons
ISBN: 1118094352
Category : Science
Languages : en
Pages : 417
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Book Description
Covers the vastly expanding subject of oxidative processes mediated by copper ions within biological systems Copper-mediated biological oxidations offer a broad range of fundamentally important and potentially practical chemical processes that cross many chemical and pharmaceutical disciplines. This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology is divided into three logical areas within the topic of copper/oxygen chemistry— biological systems, theory, and bioinorganic models and applications—to explore the biosphere for its highly evolved and thus efficient oxidative transformations in the discovery of new types of interactions between molecular oxygen and copper ion. Featuring a diverse collection of subject matter unified in one complete and comprehensive resource, Copper-Oxygen Chemistry probes the fundamental aspects of copper coordination chemistry, synthetic organic chemistry, and biological chemistry to reveal both the biological and chemical aspects driving the current exciting research efforts behind copper-oxygen chemistry. In addition, Copper-Oxygen Chemistry: Addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond-forming reactions as well as enantioselective oxidation chemistries Progresses from biological systems to spectroscopy and theory, and onward to bioinorganic models and applications Covers a wide array of reaction types such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing O2 molecule With thorough coverage by prominent authors and researchers shaping innovations in this growing field, this valuable reference is essential reading for bioinorganic chemists, as well as organic, synthetic, and pharmaceutical chemists in academia and industry.
Author: Nermeen Wagih Aboelella
Publisher:
ISBN:
Category :
Languages : en
Pages : 564
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Author: Janine Will
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author:
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ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 848
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Author: K.D. Karlin
Publisher: Springer Science & Business Media
ISBN: 940116875X
Category : Science
Languages : en
Pages : 510
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Book Description
Bioinorganic Chemistry of Copper focuses on the vital role of copper ions in biology, especially as an essential metalloenzyme cofactor. The book is highly interdisciplinary in its approach--the outstanding list of contributors includes coordination chemists, biochemists, biophysicists, and molecular biologists. Chapters are grouped into major areas of research interest in inorganic copper chemistry, spectroscopy, oxygen chemistry, biochemistry, and molecular biology. The book also discusses basic research of great potential importance to pharmaceutical scientists. This book is based on the first Johns Hopkins University Copper Symposium, held in August 1992. Researchers in chemistry, biochemistry, molecular biology, and medicinal chemistry will find it to be an essential reference on its subject.
Author: American Chemical Society. Committee on Professional Training
Publisher:
ISBN:
Category : Chemical engineering
Languages : en
Pages : 1646
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