Application de la dynamique des fluides (CFD) à la modélisation d'un bioréacteur gaz-liquide PDF Download
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Author: Mohammed Elqotbi
Publisher:
ISBN:
Category :
Languages : fr
Pages : 222
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Book Description
L’étude et la compréhension des interactions et des cinétiques de transfert en milieu hétérogène permettront de maîtriser aussi le comportement des molécules aux interfaces et d’en tirer profit pour la mise au point de bio-séparations des produits obtenus. La souplesse de l’outil informatique initie la compétition de cette méthode d’évaluation par simulation d’un procédé, avec la réalité elle-même du procédé pratiqué jusqu’à présent à travers le modèle de laboratoire ou le modèle-pilote largement plus coûteux sur plus d’un plan. Les méthodes numériques adaptées à ce type de problèmes se sont bien développées ces dernières décennies et le matériel supportant le calcul lui-même ne cesse de se mettre à la portée des modestes moyens d’acquisition. La réaction biologique, à l’instar de la réaction chimique aura donc la possibilité de tirer quelques profits de ce moyen d’étude non intrusif et sans dommages économiques ou même écologiques.
Author: Mohammed Elqotbi
Publisher:
ISBN:
Category :
Languages : fr
Pages : 222
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Book Description
L’étude et la compréhension des interactions et des cinétiques de transfert en milieu hétérogène permettront de maîtriser aussi le comportement des molécules aux interfaces et d’en tirer profit pour la mise au point de bio-séparations des produits obtenus. La souplesse de l’outil informatique initie la compétition de cette méthode d’évaluation par simulation d’un procédé, avec la réalité elle-même du procédé pratiqué jusqu’à présent à travers le modèle de laboratoire ou le modèle-pilote largement plus coûteux sur plus d’un plan. Les méthodes numériques adaptées à ce type de problèmes se sont bien développées ces dernières décennies et le matériel supportant le calcul lui-même ne cesse de se mettre à la portée des modestes moyens d’acquisition. La réaction biologique, à l’instar de la réaction chimique aura donc la possibilité de tirer quelques profits de ce moyen d’étude non intrusif et sans dommages économiques ou même écologiques.
Author: Hamid Reza Norouzi
Publisher: John Wiley & Sons
ISBN: 1119005299
Category : Technology & Engineering
Languages : en
Pages : 432
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Book Description
Discusses the CFD-DEM method of modeling which combines both the Discrete Element Method and Computational Fluid Dynamics to simulate fluid-particle interactions. Deals with both theoretical and practical concepts of CFD-DEM, its numerical implementation accompanied by a hands-on numerical code in FORTRAN Gives examples of industrial applications
Author: Jérôme Morchain
Publisher: ISTE Group
ISBN: 1784053570
Category : Bioreactors
Languages : fr
Pages : 205
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Book Description
La simulation dynamique des bioréacteurs constitue un challenge fondamental pour le monde industriel comme pour le monde académique. Au-delà du nombre important de phénomènes physiques et biologiques à considérer, et de la large gamme d’échelles impliquées, la difficulté centrale réside dans la nécessité de rendre compte du comportement dynamique des micro-organismes en suspension, ceux-ci ayant la capacité de moduler la vitesse d’assimilation des substrats. La nature de ces transformations biochimiques résulte d’un véritable compromis entre les besoins de la cellule et les ressources disponibles. Cet ouvrage analyse la modélisation des bioréacteurs en s’appuyant sur une approche multi-échelle. Il traite des questions relatives au mélange, aux transferts entre phases, à l’adaptation des micro-organismes aux variations de concentration et offre une ouverture sur l’utilisation des bilans de population pour la simulation des bioréacteurs.
Author: Vincent Ke Sen Ngu
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Upscaling biochemical processes from the laboratory scale to industrial scale is very challenging as performance losses are typically observed along the scale-up process. In this context, numerical models are required to perform predictive modelling and bioreactor simulations which facilitate the scale-up procedure, leading to an optimum reactor design and improved performances. In this thesis, the bioreactor design of interest is the bubble column reactor. Bubble column reactors are widely used in the chemical and bioprocess industries due to their good mixing, heat and mass transfer properties. However, the modelling of bubble columns is very challenging due to highly coupled multiphysics phenomena in terms of multiphase flow, mass transfer and (bio)reaction. The present work aims to unravel the coupling mechanisms by using a multiscale modelling approach and attempts to model bubble column bioreactors under a wide range of conditions and applications. In this PhD thesis, a novel two-way coupled spatio-temporal 1D model is proposed to tackle the hydrodynamics and (bio)reactive mass transfer two-way coupling phenomenon. The model validation has been conducted using own-measured hydrodynamics data and biological methanation experimental data obtained by the Symbiose team at Toulouse Biotechnology Institute. Furthermore, literature data and numerical test cases have been used to validate the model, particularly the hydrodynamics and mass transfer aspects of the model. Following the model validation, the comprehensive, dynamic 1D model has been applied to perform multiphysics simulations of different (bio)processes, including CO2 physical absorption, CO2 chemisorption, oxygen transfer, biological methanation, and yeast fermentation, highlighting the robustness of the model. For instance, the 1D model predicts the substrate gradients in industrial-scale fermenters just as well as the CFD model. Similarly, in the chemical engineering context, the 1D model yields relatively well the CO2 mass transfer in a reactive bubble column, compared with the CFD model. The particularity of these processes is the fact that the major substrates are fed through the gas phase, leading to the possibility of a gas-liquid mass transfer limitation regime. For example, biological methanation is usually limited by the hydrogen mass transfer phenomenon. In this work, a practical biological methanation model is proposed to handle the bioreaction descriptions in both biological and physical transport limiting regimes. Moreover, Eulerian CFD model is also developed for biological methanation process and a detailed comparison with the experimental data and 1D model predictions is conducted. Asymptotic 0D models and analytical solutions have also been developed for some applications to shed light on the underlying process and highlight the controlling parameters. This multiscale modelling strategy has drawn new fundamental insights into multiphase reactor modelling, primarily the use of appropriate models according to the subject of research, the implementation of suitable closures in the modelling of multiphysics coupling phenomena, and the identification ofcontrolling parameters of such processes. In short, through this PhD thesis, efficient numerical modelling tools (0D, 1D, and CFD models) have been developed for primarily bubble column applications to gain an understanding of the multiscale physical and biological phenomena in order to minimise the risk of upscaling the bioprocess.
Author: Andrea Prosperetti
Publisher: Cambridge University Press
ISBN: 1139459902
Category : Mathematics
Languages : en
Pages : 392
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Book Description
Thanks to high-speed computers and advanced algorithms, the important field of modelling multiphase flows is an area of rapid growth. This one-stop account – now in paperback, with corrections from the first printing – is the ideal way to get to grips with this topic, which has significant applications in industry and nature. Each chapter is written by an acknowledged expert and includes extensive references to current research. All of the chapters are essentially independent and so the book can be used for a range of advanced courses and the self-study of specific topics. No other book covers so many topics related to multiphase flow, and it will therefore be warmly welcomed by researchers and graduate students of the subject across engineering, physics, and applied mathematics.
Author: M. Y. Chisti
Publisher: Springer
ISBN:
Category : Science
Languages : en
Pages : 368
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Book Description
Author: Ernst Heinrich Hirschel
Publisher: Springer Science & Business Media
ISBN: 3540708057
Category : Technology & Engineering
Languages : en
Pages : 507
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Book Description
In a book that will be required reading for engineers, physicists, and computer scientists, the editors have collated a number of articles on fluid mechanics, written by some of the world’s leading researchers and practitioners in this important subject area.
Author: Brigitte Gasser
Publisher: Humana Press
ISBN: 9781493990238
Category : Science
Languages : en
Pages : 431
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Book Description
This volume provides an overview of the main yeast production platforms currently used and future yeast cell factories for recombinant protein production. Chapters detail approaches of genetic and metabolic engineering, co-factor containing proteins and virus-like particles, glycoproteins, and post-translational modifications of proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Recombinant Protein Production in Yeast: Methods and Protocols aims to provide state of the art background and methods for protein producing yeast platforms, as well as case studies for special applications.
Author: Wolf-Dieter Deckwer
Publisher: John Wiley & Sons
ISBN:
Category : Science
Languages : en
Pages : 564
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Book Description
This technology, though used for many years, has shown great vitality recently and is still in a state of flux. Provides an account of developments up to the present and also an orderly evaluation of literature already published on the subject. Considerable space is devoted to bubble column reactor performance predictions based on mathematical models and the importance of each is explained with practical examples.
Author: World Bank
Publisher: World Bank Publications
ISBN: 0821385631
Category : Social Science
Languages : en
Pages : 114
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Book Description
This report provides the most comprehensive and rigorous analysis of Iraqi income and expenditure in several decades. The report makes extensive use of the Iraq Household Socio-Economic Survey, the first nationwide income and expenditure survey since 1988. IHSES data is complemented income and expenditure data from a wide range of other measures of living standards, allowing us to analyze living standards in a holistic way. The analysis presented here was performed with two main goals first, to inform the Government s Poverty Reduction Strategy; and second, to serve as a baseline for future assessments of changes in living standards and the identification of critical issues for deeper examination. Iraqi living standards have two unusual characteristics. First, they have fallen over the past generation. Second, they feature surprisingly little inequality. These characteristics are both rooted in Iraq s recent history of authoritarian government, war, military occupation, insurgency, and civil strife leading to infrastructure destruction and population displacement. There have been few opportunities for individuals to prosper from professional or entrepreneurial activities. Decades of neglected investment have resulted in deterioration of social services and economic infrastructure. Consequently, individuals have lacked capabilities to prosper and an investment climate conducive to prosperity. School enrollment and life expectancy have declined. Extremely low returns to education reflect the combination of poor educational quality and lack of employment opportunities. In terms of economic infrastructure, access to reliable electricity and water, and even access to paved roads are low, are further reflections of decades of neglect. While the upper end of the distribution has been pulled down by a lack of opportunities, the lower end has been supported by direct government provision of food. The Public Distribution System (PDS) provides 85 percent of food needs. While PDS has been useful as a safety net for the poor and the vulnerable, the system is expensive, inefficient, and fiscally risky. Indeed, PDS food rations account for a far greater share of public spending than does education or health. Going forward, Iraq faces two main challenges. First, although Iraq does not have to develop from scratch, it faces a formidable challenge in re-development. Second, a shift by the Government is required from direct provision of basic subsistence toward investment in human capacities. The Government can provide an enabling environment through investments in economic infrastructure and services to business and citizens, thus allowing the population to make productive use of education and their own labor. Both challenges are now being taken up by the Poverty Reduction Strategy, which articulates a detailed set of required actions and outlines priorities for government spending.
