Author:
Publisher: Elsevier
ISBN: 0080496709
Category : Science
Languages : en
Pages : 614
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Book Description
Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods that inhibit gene expression permit studies which probe the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedical-oriented research.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Author: Phillips, I M
Publisher:
ISBN:
Category : Antisense RNA.
Languages : en
Pages : 0
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Book Description
Author: Macy Rose
Publisher: Callisto Reference
ISBN: 9781641167857
Category : Science
Languages : en
Pages : 0
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Book Description
Antisense RNA (asRNA) refers to a type of single-stranded RNA. It hybridizes with protein coding messenger RNA (mRNA) and complements it to inhibit its translation into a protein. Eukaryotes and prokaryotes, both have naturally occuring asRNAs in them. They can be divided into two types including short and long non-coding RNAs (ncRNAs). asRNAs primarily control the gene expression and are widely utilized as tools for gene knockdown. Antisense technology offers effective experimental methods for examining gene function and gene regulation by modifying gene expression in mammalian cells. Many RNA-based antisense therapies are being developed currently. However, effective delivery of these therapies to target tissues remains the primary barrier in their clinical application. Antisense technology has a wide range of applications in the treatment of numerous diseases such as viral infections, cancer, and immunological, cardiovascular, ocular and neurological diseases. This book contains some path-breaking studies in antisense technology. It consists of contributions made by international experts. This book is a vital tool for all researching or studying antisense RNA as it gives incredible insights into its design and delivery.
Author: Phillips, I M
Publisher:
ISBN:
Category : Antisense RNA.
Languages : en
Pages : 0
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Book Description
Author: Virginia Arechavala-Gomeza
Publisher: Humana
ISBN: 9781071620120
Category : Psychology
Languages : en
Pages : 422
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Book Description
This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Jens Kurreck
Publisher: Royal Society of Chemistry
ISBN: 0854041168
Category : Medical
Languages : en
Pages : 362
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Book Description
This book provides a compelling overall update on current status of RNA interference
Author: Stanley T. Crooke
Publisher: CRC Press
ISBN: 1439832501
Category : Medical
Languages : en
Pages : 848
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Book Description
Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generati
Author: Volker A. Erdmann
Publisher: Springer Science & Business Media
ISBN: 3642121683
Category : Medical
Languages : en
Pages : 460
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Book Description
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
Author:
Publisher: Elsevier
ISBN: 0080496717
Category : Science
Languages : en
Pages : 683
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Book Description
Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriented research.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.
