Model Behavior

Model Behavior PDF Author: Nicole C. Nelson
Publisher: University of Chicago Press
ISBN: 022654611X
Category : Science
Languages : en
Pages : 262

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Book Description
Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.

Model Behavior

Model Behavior PDF Author: Nicole C. Nelson
Publisher: University of Chicago Press
ISBN: 022654611X
Category : Science
Languages : en
Pages : 262

Get Book Here

Book Description
Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease PDF Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0124159125
Category : Science
Languages : en
Pages : 1109

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Book Description
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309038391
Category : Science
Languages : en
Pages : 113

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Book Description
Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Animal Models in Human Psychobiology

Animal Models in Human Psychobiology PDF Author: George Serban
Publisher:
ISBN: 9781468421859
Category :
Languages : en
Pages : 316

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Book Description


Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 030916785X
Category : Science
Languages : en
Pages : 223

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Book Description
Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Animal Emotions

Animal Emotions PDF Author: Kenneth L Davis
Publisher:
ISBN: 9781950192908
Category :
Languages : en
Pages : 160

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Book Description
Animal Emotions: How They Drive Human Behavior gives a concise overview of ancient mammalian emotions deeply rooted in the human brain. Jaak Panksepp, a world-renowned neuroscientist, dedicated his life career to the study of mammalian emotions and he carved out seven distinct emotional systems he called seeking, lust, care, and play (positive emotions), and fear, anger, and sadness (negative emotions), all exerting a tremendous influence on human behavior.Christian Montag, a neuroscientist and psychologist, and a long-time collaborator of Jaak Panksepp, revisits together with Kenneth L. Davis, one of Jaak's PhD students, Panksepp's theories and provides the reader with new insights into the nature of emotions and their role as survival tools, both for animals and for humans. They also raise new questions about the background of the research field Jaak Panksepp coined "Affective Neuroscience." How are personality and psychopathology linked to animal emotions? Do animals feel the same way as we do? What are our emotional needs in a digital society, and what is key to a happy life?

Anxiety and Anxiolytic Drugs

Anxiety and Anxiolytic Drugs PDF Author: Florian Holsboer
Publisher: Springer Science & Business Media
ISBN: 9783540225683
Category : Medical
Languages : en
Pages : 588

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Book Description
The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.

Science, Medicine, and Animals

Science, Medicine, and Animals PDF Author: Committee on the Use of Animals in Research (U.S.)
Publisher: National Academies Press
ISBN:
Category : Medical
Languages : en
Pages : 48

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Book Description
The necessity for animal use in biomedical research is a hotly debated topic in classrooms throughout the country. Frequently teachers and students do not have access to balanced,  factual material to foster an informed discussion on the topic. This colorful, 50-page booklet is designed to educate teenagers about the role of animal research in combating disease, past and present; the perspective of animal use within the whole spectrum of biomedical research; the regulations and oversight that govern animal research; and the continuing efforts to use animals more efficiently and humanely.

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Improving the Utility and Translation of Animal Models for Nervous System Disorders PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309266335
Category : Medical
Languages : en
Pages : 111

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Book Description
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Methods of Behavior Analysis in Neuroscience

Methods of Behavior Analysis in Neuroscience PDF Author: Jerry J. Buccafusco
Publisher: CRC Press
ISBN: 1420041819
Category : Medical
Languages : en
Pages : 341

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Book Description
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic