Anatomical and Functional Lung Imaging with MRI PDF Download
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Languages : en
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Author: Marta Tibiletti
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Languages : en
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Author: Marta Tibiletti
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Languages : en
Pages : 0
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Author: Hans-Ulrich Kauczor
Publisher: Springer Science & Business Media
ISBN: 354034618X
Category : Medical
Languages : en
Pages : 315
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Book Description
During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.
Author: Yoshiharu Ohno
Publisher: Springer Nature
ISBN: 3030435393
Category : Medical
Languages : en
Pages : 363
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This book reviews the basics of pulmonary functional imaging using new CT and MR techniques and describes the clinical applications of these techniques in detail. The intention is to equip readers with a full understanding of pulmonary functional imaging that will allow optimal application of all relevant techniques in the assessment of a variety of diseases, including COPD, asthma, cystic fibrosis, pulmonary thromboembolism, pulmonary hypertension, lung cancer and pulmonary nodule. Pulmonary functional imaging has been promoted as a research and diagnostic tool that has the capability to overcome the limitations of morphological assessments as well as functional evaluation based on traditional nuclear medicine studies. The recent advances in CT and MRI and in medical image processing and analysis have given further impetus to pulmonary functional imaging and provide the basis for future expansion of its use in clinical applications. In documenting the utility of state-of-the-art pulmonary functional imaging in diagnostic radiology and pulmonary medicine, this book will be of high value for chest radiologists, pulmonologists, pulmonary surgeons, and radiation technologists.
Author: Johny A. Verschakelen
Publisher: Springer
ISBN: 364239518X
Category : Medical
Languages : en
Pages : 229
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Computed Tomography of the Lung: A Pattern Approach aims to enable the reader to recognize and understand the CT signs of lung diseases and diseases with pulmonary involvement as a sound basis for diagnosis. After an introductory chapter, basic anatomy and its relevance to the interpretation of CT appearances is discussed. Advice is then provided on how to approach a CT scan of the lungs, and the different distribution and appearance patterns of disease are described. Subsequent chapters focus on the nature of these patterns, identify which diseases give rise to them, and explain how to differentiate between the diseases. The concluding chapter presents a large number of typical and less typical cases that will help the reader to practice application of the knowledge gained from the earlier chapters. Since the first edition, the book has been adapted and updated, with the inclusion of many new figures and case studies.
Author: Marcus Couch
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Languages : en
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Fluorine-19 (19F) magnetic resonance imaging (MRI) of the lungs using inhaled inert fluorinated gases can potentially provide high quality anatomical and functional images of the lungs. This technique is able to visualize the distribution of the inhaled gas, similar to hyperpolarized (HP) helium-3 (3He) and xenon-129 (129Xe) MRI. Inert fluorinated gases have the advantages of being nontoxic, abundant, and inexpensive compared to HP gases. Due to the high gyromagnetic ratio of 19F, there is sufficient thermally polarized signal for imaging, and averaging within a single breath-hold is possible due to short longitudinal relaxation times. Since inert fluorinated gases do not need to be hyperpolarized prior to their use in MRI, this eliminates the need for an expensive polarizer and expensive isotopes. Inert fluorinated gas MRI of the lungs has been studied extensively in animals since the 1980s, and more recently in healthy volunteers and patients with lung diseases. This thesis focused on the development of static breath-hold inert fluorinated gas MR imaging techniques, as well as the development functional imaging biomarkers in humans and animal models of pulmonary disease. Optimized ultrashort echo time (UTE) 19F MR imaging was performed in healthy volunteers, and images from different gas breathing techniques were quantitatively compared. 19F UTE MR imaging was then quantitatively compared to 19F gradient echo imaging in both healthy volunteers and in a resolution phantom. A preliminary comparison to HP 3He MR imaging is also presented, along with preliminary 19F measurements of the apparent diffusion coefficient (ADC) and iv gravitational gradients of ventilation in healthy volunteers. The potential of inert fluorinated gas MRI in detecting pulmonary diseases was further explored by performing ventilation mapping in animal models of inflammation and fibrosis. Overall, interest in pulmonary 19F MRI of inert fluorinated gases is increasing, and numerous sites around the world are now interested in developing this technique. This work may help to demonstrate that inert fluorinated gas MRI has the potential to be a viable clinical imaging modality that can provide useful information for the diagnosis and management of chronic respiratory diseases.
Author: Daniel A. Lichtenstein
Publisher: Springer
ISBN: 3319153714
Category : Medical
Languages : en
Pages : 394
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Written by a pioneer in critical care ultrasound, this book discusses the basic technique and “signatures” of lung ultrasound and explains its main clinical applications. The tools and clinical uses of the BLUE protocol, which allows diagnosis of most cases of acute respiratory failure, are first described in detail. Careful attention is then devoted to protocols derived from the BLUE protocol – the FALLS protocol for diagnosis and management of acute circulatory failure, the Pink protocol for use in ARDS, and the SESAME protocol for use in cardiac arrest – and to the LUCI-FLR program, a means of answering clinical questions while reducing radiation exposure. Finally, the book discusses all the possible settings in which lung ultrasound can be used, discipline by discipline and condition by condition. Lung Ultrasound in the Critically Ill comprehensively explains how ultrasound can become the stethoscope of modern medicine. It is a superb complement to the author’s previous book, Whole Body Ultrasonography in the Critically Ill.
Author: Juerg Hodler
Publisher: Springer
ISBN: 3030111490
Category : Medical
Languages : en
Pages : 238
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Book Description
This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.
Author: Brandon Zanette
Publisher:
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Languages : en
Pages :
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Hyperpolarized (HP) 129Xe Magnetic Resonance Imaging (MRI) of the lungs allows for the visualization of the spatial distribution of gas in the pulmonary airspaces upon inhalation by taking advantage of the 100,000 fold increase in signal. This technique yields high quality anatomical and functional images of the lungs that is otherwise difficult with conventional MRI. Direct imaging of lung ventilation is useful for the detection and quantification of obstructive lung diseases such as cystic fibrosis, chronic obstructive pulmonary disorder, and asthma. An added advantage of 129Xe is its solubility in bodily tissues such as the lung parenchyma and red blood cells, allowing for the detection of signals from beyond the airspaces. This property of 129Xe may be exploited to probe gas exchange upon inhalation, making HP 129Xe MRI a powerful tool for the investigation of terminal airway dysfunction in a variety of pulmonary diseases. However, the inherent challenges associated with dissolved 129Xe MRI has caused development of these techniques to lag ventilation (gas-phase) HP 129Xe MRI. The work in this thesis is focused on the technical development of dissolved 129Xe imaging techniques for use in both human and rodent experiments. A particular focus is given to radiation-induced lung injury (RILI), a serious and debilitating consequence of radiotherapy that affects a subset of patients. A new rat model of RILI that better represents regional injury is developed and tested. Temporally-resolved dissolved 129Xe imaging techniques for gas exchange mapping are developed and applied to the study of RILI in this model. Changes in lung physiology associated with radiation injury are quantified by parametrically mapping gas exchange. Finally, the techniques developed preclinically are modified and improved for clinical use. Parametric gas exchange mapping is demonstrated in humans. Accelerated dissolved 129Xe MRI with parallel imaging is also demonstrated. The results of this work will aid in the translations of dissolved 129Xe MRI into a clinically useful technique for a variety of lung diseases affecting gas exchange in the lungs, such as RILI.
