Analysis of the SIN1 and SIN2 Gene Products and Their Role in Transcriptional Regulation in Saccharomyces Cerevisiae PDF Download
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Author: Warren David Kruger
Publisher:
ISBN:
Category : Genetic transcription
Languages : en
Pages : 402
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Book Description
Author: Warren David Kruger
Publisher:
ISBN:
Category : Genetic transcription
Languages : en
Pages : 402
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Book Description
Author: Steven L. McKnight
Publisher:
ISBN:
Category : Genetic regulation
Languages : en
Pages : 728
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Author: Priyasri Shotton
Publisher:
ISBN:
Category :
Languages : en
Pages : 268
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Book Description
DNA is the storehouse of genetic information for the normal functioning of all cellular processes. This DNA is "read" by RNA Polymerases (RNAP) to carry out the transcription process, which is one of the most vital regulatory mechanisms within the cell for gene expression. There are three important RNA Polymerases available in the cell. RNAPI synthesizes ribosomal RNAs, while RNAPII makes mRNA precursors, snRNAs and most microRNAs, additionally RNAPIII takes care of tRNAs, small RNAs and 5S rRNAs that occur in the nucleus and the cytosol. The work in the author's lab focuses on the function of RNAPII transcription. It is not straightforward for RNAPII to transcribe the DNA, it needs to struggle with two major roadblocks that are in its path. First, is the nucleosomal barrier that is scattered across the coding regions of active genes. The mechanism to overcome this major obstacle is a very complex process that involves an extensive range of proteins which work collectively to help in the alteration of chromatin structure that ultimately facilitates transcriptional regulation. In the thesis, the author has attempted to take a look at this intricate network and has studied the function of Rad26p, in yeast (associated with CSB-Cockayne syndrome B, in humans), a transcription coupled DNA repair factor, having an additional role in transcription. The results reveal that Rad26p plays a novel role in the regulation of elongation by modulating histone H2A-H2B dimer occupancy.
Author: Anita Sil
Publisher:
ISBN:
Category : Cell division
Languages : en
Pages : 468
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Author: Christopher T. Harbison
Publisher:
ISBN:
Category :
Languages : en
Pages : 456
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Book Description
Historically, knowledge of gene-specific transcription has been accumulated by the study of the individual genetic and physical interactions between transcriptional regulators and the genes they regulate, often requiring considerable time and effort. Microarray technology now enables investigation of gene expression at the level of the entire genome, allowing researchers access to rich datasets and promising new levels of depth in the understanding of transcriptional regulation. Our lab has made use of these technologies both to measure the levels of all mRNA transcripts within a population of cells, as well as to locate the regions within the genome that are bound by transcriptional regulators. Such studies not only allow for the functional annotation of both genes and regulators, but can also provide clues about the identity of the regulatory regions within DNA, the structure of global regulatory networks and the regulation of DNA-binding proteins. These and other insights are presented here based on our genome-wide studies of transcriptional regulation in the yeast Saccharomyces cerevisiae.
Author: Naoko Kobayashi
Publisher:
ISBN:
Category : Genetic regulation
Languages : en
Pages : 422
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Author: Chang Seo Park
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ISBN:
Category :
Languages : en
Pages : 384
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Author: Joanne Irene Adamkewicz
Publisher:
ISBN:
Category :
Languages : en
Pages : 338
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Author: Heng Zhou
Publisher:
ISBN:
Category : Genetic regulation
Languages : en
Pages :
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Author: James R. Broach
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 822
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Book Description
The burgeoning appreciation of yeasts as model systems for the study of fundamental cellular processes has highlighted the need for an update of the seminal 1981 monograph The Molecular Biology of the Yeast Saccharomyces. This need is now met by the publication of a three-volume series to serve as the authoritative sequel. The first volume focuses on the genome organization of the yeast Saccharomyces as well as protein translation and its regulation and energy metabolism. Subsequent volumes emphasize such topics as the cell cycle, secretion, and transcription. Together, these volumes provide a comprehensive survey of the molecular and cellular biology of Saccharomyces and Schizosaccharomyces, serving not only as a current summary of every significant area of investigation, but also as a thorough reference source. These volumes are required reading for every-one in the field and anyone curious about the state of the art of molecular and cellular biology.
