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Author: Rafael Beyar
Publisher: John Wiley & Sons
ISBN: 1573317470
Category : Science
Languages : en
Pages : 241
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Book Description
This volume, the result of three days of interactive sessions among world leaders in the cardiac sciences, summarizes the most up-to-date information about development and cardiogenesis signaling in cell-based therapy, as well as developmental aspects of the formation of the embryonic heart, including the effect of mechanical load on differentiation. Other topics covered include: signaling and repair strategies, cell and gene therapy for the treatment of postmyocardial infarction, signaling, vascularization methods in engineering embryonic cardiac tissue, and molecular methods to improve survival of human embryonic stem cell–derived cardiomyocytes; developmental and evolutional cardiology; novel strategies for treatment of atrial fibrillation and channel molecular physiology in remodeling and hypertrophy; multiscale modeling for metabolism and flows, including force development, mechanics of cardiac contraction, and ATP supply and demand aspects; aging, interactions, and interference aspects include fibroblast-myocyte-capillary communications, nonuniformities in contraction, calcium channels as oxygen sensors, and epigenetics of heart failure; and macroscale phenomena and clinical aspects, including various clinical aspects of modern cardiology such as navigation methods for cardiac interventions and control of cardiac function by changes in energetic demand. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Author: Rafael Beyar
Publisher: John Wiley & Sons
ISBN: 1573317470
Category : Science
Languages : en
Pages : 241
Get Book Here
Book Description
This volume, the result of three days of interactive sessions among world leaders in the cardiac sciences, summarizes the most up-to-date information about development and cardiogenesis signaling in cell-based therapy, as well as developmental aspects of the formation of the embryonic heart, including the effect of mechanical load on differentiation. Other topics covered include: signaling and repair strategies, cell and gene therapy for the treatment of postmyocardial infarction, signaling, vascularization methods in engineering embryonic cardiac tissue, and molecular methods to improve survival of human embryonic stem cell–derived cardiomyocytes; developmental and evolutional cardiology; novel strategies for treatment of atrial fibrillation and channel molecular physiology in remodeling and hypertrophy; multiscale modeling for metabolism and flows, including force development, mechanics of cardiac contraction, and ATP supply and demand aspects; aging, interactions, and interference aspects include fibroblast-myocyte-capillary communications, nonuniformities in contraction, calcium channels as oxygen sensors, and epigenetics of heart failure; and macroscale phenomena and clinical aspects, including various clinical aspects of modern cardiology such as navigation methods for cardiac interventions and control of cardiac function by changes in energetic demand. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Author: Benoit G. Bruneau
Publisher:
ISBN: 9781621823582
Category : Medical
Languages : en
Pages : 0
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Book Description
Development of the heart is a complex process and can lead to serious congenital disease if the process goes awry. This book provides a detailed description of the cell lineages involved in heart development and how their migration and morphogenesis are controlled. It also examines the genetic and environmental bases for congenital heart disease and how model systems are revealing more about the processes involved. Topics covered in this essential volume include: - Anatomy of a Developing Heart - Genetic and Epigenetic Control of Heart Development - Development of the Cardiac Conduction System - Genetic Basis of Human Congenital Heart Disease - In Vivo and In Vitro Genetic Models of Congenital Heart Disease
Author: Thomas W. Yee
Publisher: Springer
ISBN: 149392818X
Category : Mathematics
Languages : en
Pages : 606
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Book Description
This book presents a greatly enlarged statistical framework compared to generalized linear models (GLMs) with which to approach regression modelling. Comprising of about half-a-dozen major classes of statistical models, and fortified with necessary infrastructure to make the models more fully operable, the framework allows analyses based on many semi-traditional applied statistics models to be performed as a coherent whole. Since their advent in 1972, GLMs have unified important distributions under a single umbrella with enormous implications. However, GLMs are not flexible enough to cope with the demands of practical data analysis. And data-driven GLMs, in the form of generalized additive models (GAMs), are also largely confined to the exponential family. The methodology here and accompanying software (the extensive VGAM R package) are directed at these limitations and are described comprehensively for the first time in one volume. This book treats distributions and classical models as generalized regression models, and the result is a much broader application base for GLMs and GAMs. The book can be used in senior undergraduate or first-year postgraduate courses on GLMs or categorical data analysis and as a methodology resource for VGAM users. In the second part of the book, the R package VGAM allows readers to grasp immediately applications of the methodology. R code is integrated in the text, and datasets are used throughout. Potential applications include ecology, finance, biostatistics, and social sciences. The methodological contribution of this book stands alone and does not require use of the VGAM package.
Author: Junjie Xiao
Publisher: Springer
ISBN: 9811043973
Category : Science
Languages : en
Pages : 300
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Book Description
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470868031
Category : Medical
Languages : en
Pages : 300
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Book Description
The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.
Author: Florin Mihail Filipoiu
Publisher: Springer Science & Business Media
ISBN: 1447153820
Category : Medical
Languages : en
Pages : 254
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Book Description
This heart anatomy book describes the cardiac development and cardiac anatomy in the development of the adult heart, and is illustrated by numerous images and examples. It contains 550 images of dissected embryo and adult hearts, obtained through the dissection and photography of 235 hearts. It has been designed to allow the rapid understanding of the key concepts and that everything should be clearly and graphically explained in one book. This is an atlas of cardiac development and anatomy of the human heart which distinguishes itself with the use of 550 images of embryonic, fetal and adult hearts and using text that is logical and concise. All the mentioned anatomical structures are shown with the use of suggestive dissection images to emphasize the details and the overall location. All the images have detailed comments, while clinical implications are suggested. The dissections of different hearts exemplify the variability of the cardiac structures. The electron and optical microscopy images are sharp and provide great fidelity. The arterial molds obtained using methyl methacrylate are illustrative and the pictures use suggestive angles. The dissections were made on human normal and pathological hearts of different ages, increasing the clinical utility of the material contained within.
Author: Nadia Rosenthal
Publisher: Academic Press
ISBN: 0123813336
Category : Science
Languages : en
Pages : 1126
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Book Description
The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. - Authored by world experts in heart development and disease - New research on epigenetic modifiers in cardiac development - Comprehensive coverage of stem cells and prospects for cardiac regeneration - Up-to-date research on transcriptional and proteomic circuits in cardiac disease - Full-color, detailed illustrations
Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0
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Book Description
Author: Makoto Nagano
Publisher: Springer Science & Business Media
ISBN: 9781402070525
Category : Medical
Languages : en
Pages : 296
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Book Description
The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.
Author: Masaki Ieda
Publisher: Springer
ISBN: 3319561065
Category : Medical
Languages : en
Pages : 277
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Book Description
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
