Analysis of Blood Flow Dynamics in a Simple Microvascular Network PDF Download
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Author: Yingyi Lao
Publisher:
ISBN:
Category :
Languages : en
Pages : 252
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Book Description
Author: Yingyi Lao
Publisher:
ISBN:
Category :
Languages : en
Pages : 252
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Book Description
Author: Fan Wu
Publisher:
ISBN:
Category :
Languages : en
Pages : 230
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Book Description
Author: Aleksander Popel
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Medical
Languages : en
Pages : 244
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Book Description
Author:
Publisher: Elsevier
ISBN: 012805154X
Category : Medical
Languages : en
Pages : 2854
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Book Description
Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.
Author: John K-J. Li
Publisher: World Scientific
ISBN: 9810249071
Category : Medical
Languages : en
Pages : 270
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Book Description
This book begins with the historical discoveries of the features ofthe vascular system and its importance in the overall circulatoryfunction. Modern aspects of vascular biology in terms of structure andfunction are then described, followed by the introduction of physicalprinciples and basic fluid mechanics for quantitative analysis. Thehemodynamics of large arteries, the optimal structure of vascularbranching and the pulsatile energy transmission and modeling aspectsare elaborated. These are extended to analyze the function of thevenous system and the microcirculation. Finally, the integratedv.
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Roland N. Pittman
Publisher: Biota Publishing
ISBN: 1615047212
Category : Medical
Languages : en
Pages : 117
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Book Description
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Author: Yujia Qi
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Microvasculature structures vary drastically from species to species, and from organs to organs. Different structures signify inclinations of distinct blood flow perfusion features: uniform, or localized? Robust, or efficient? Like the vertebrate tissues having preferred types of vasculature systems that emphasize different traits, in the course of my research, I chose two contrasting systems to be studied by virtue of their specific features: mammalian cerebral cortex microvasculature, and zebrafish embryo trunk microvasculature. For mammalian cerebral microvasculature, considering the distinguished hierarchical construction, and the complex, dense nature of the capillary bed perfusing brain tissue, a model that abstracts the structure while revealing the relationship between blood perfusion and network properties would be extremely helpful; in contrast, zebrafish embryo trunk microvasculature is by itself a simple structure, but being an embryo, its hemodynamic features still undergo developments, and the network would adapt accordingly, which provides an excellent model to study microvascular network adaptation. Specifically, in different mammalian cortices, I found that the dense, parallel penetrating vessels perfusing the cerebral cortex -- arterioles and venules, are consistently in imbalanced ratios. Whether and how the arteriole-venule arrangement and ratio affect the efficiency of energy delivery to the cortex has never been asked before. I show by mathematical modeling and analysis of the mapped mouse sensory cortex that the perfusive efficiency of the network is predicted to be limited by low flow regions produced between pairs of arterioles or pairs of venules. Increasing either arteriole or venule density decreases the size of these low flow regions but increases their number, setting an optimal ratio between arterioles and venules that closely matches that observed across mammalian cortical vasculature. Low flow regions are reshaped in complex ways by changes in vascular conductance, creating geometric challenges for matching cortical perfusion with neuronal activity. Within the zebrafish trunk, tuning of vessel radii ensures red blood cells are delivered at equal rates across tens of microvessels. How do vessels find optimal radii? Vessels are known to adapt their radii to maintain the shear stress from blood flow at the vessel wall at a set point. Yet models of adaptation purely on the basis of average shear stress have not, until now, been able to produce complex loopy networks that resemble real microvascular systems. The shear stress on real vessel endothelia peaks sharply when a red blood cell passes through the vessel. I show that if vessel shear stress set points are cued to the stress peaks, then stable shear-stress-based adaptation is possible. Model networks that respond to peak stresses alone can quantitatively reproduce the observed zebrafish trunk microvasculature, including its adaptive trajectory when hematocrit changes. My work reveals the potential for mechanotransduction alone to generate stable hydraulically tuned microvascular networks. When parts of the zebrafish network -- the anastomoses in the distant trunk that connects the artery and the vein directly -- are amputated, a localization of blood flow at the zebrafish tail is observed in my adaptation model, which is verified through experiments. This discovery highlights a specific structure's function, which can only be identified under network adaptation, and shows the significance of taking adaptation into account when evaluating a vascular structure's hemodynamic functions.
Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
ISBN: 4431683674
Category : Medical
Languages : en
Pages : 330
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Book Description
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Author: Sergey S. Shevkoplyas
Publisher:
ISBN:
Category :
Languages : en
Pages : 258
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Book Description
Abstract: The primary physiological function of the cardiovascular system, i.e. the delivery of oxygen and nutrients to and the removal of metabolic waste products from living tissues, is performed by the microcirculation. It is also where key events of the immune response such as leukocyte margination, rolling and subsequent diapedesis take place. Microvascular blood flow dynamics have a major impact on all of these vital processes. We used silicon micromachining and polydimethylsiloxane replica molding to create microchannel networks with dimensions and topology similar to the real microcirculation. These networks provide high quality of imaging and unprecedented control over all hemodynamically relevant parameters. We reproduced and documented a number of key blood flow dynamics and phenomena characteristic of the microcirculation in vivo using whole blood and blood cell suspensions of varying composition. This suggests the possibility to use this system as a convenient microfluidic platform for experimental studies of the mechanics of the microcirculation. The impact of blood cell rheology and interactions, plasma composition, network architecture and channel wall surface properties on microvascular network blood flow dynamics can now be addressed without interference from active biological regulation. This system will, for the first time, provide a viable bridge between computer simulations and experiments in vivo. Finally, we created a simple microfluidic device that takes advantage of plasma skimming and leukocyte margination to provide positive, continuous flow selection of leukocytes directly from microliter samples of whole blood. It produces a 34-fold enrichment of the leukocyte-to-erythrocyte ratio and requires no preliminary labeling of cells. This effortless, efficient and inexpensive technology can be used as a lab-on-a-chip component for initial whole blood sample preparation. Its integration into microanalytical devices that require leukocyte enrichment will enable accelerated transition of these devices into the field for point-of-care clinical testing.
