An Isolated Hepatocyte Model of Carbon Tetrachloride Hepatotoxicity PDF Download
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Author: Scot Davis Pencil
Publisher:
ISBN:
Category :
Languages : en
Pages : 264
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Book Description
Author: Scot Davis Pencil
Publisher:
ISBN:
Category :
Languages : en
Pages : 264
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Book Description
Author: Mary Skinner Vance
Publisher:
ISBN:
Category : Carbon tetrachloride
Languages : en
Pages : 130
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Book Description
Author: Philips W. Andrews
Publisher:
ISBN:
Category : Fatty liver
Languages : en
Pages : 36
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Book Description
A literature survey of hydrocarbon-induced, experimental, acute hepatotoxicity was made. It was concluded that carbon tetrachloride, and probably other hydrocarbons, directly interfere with the selective permeability of the liver cell wall and membranous endoplasmic reticulum for electrolytes, water, and certain hydrophilic proteins. Concomitantly the toxin stimulates the sympathetic nervous system and the release of its hormones. These reduce hepatic blood flow, by vasoconstriction, thereby inducing centrilobular hypoxia, degeneration, and necrosis. These also cause massive mobilization of fats from the peripheral depots. These fats accumulate in the liver where their secretion, as triglycerides, is blocked by unknown mechanisms. (Author).
Author: Chandrashekhar Gandhi
Publisher: Academic Press
ISBN: 0128005440
Category : Science
Languages : en
Pages : 335
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Book Description
Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.
Author: Pablo Muriel
Publisher: Academic Press
ISBN: 0128043210
Category : Science
Languages : en
Pages : 917
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Book Description
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher:
ISBN:
Category : Carcinogens
Languages : en
Pages : 332
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Book Description
Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 0123977649
Category : Technology & Engineering
Languages : en
Pages : 801
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Book Description
Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease provides valuable insights for those seeking nutritional treatment options for those suffering from liver and/or related gastrointestinal disease including Crohn’s, allergies, and colitis among others. Information is presented on a variety of foods including herbs, fruits, soy and olive oil. This book serves as a valuable resource for researchers in nutrition, nephrology, and gastroenterology. Addresses the most positive results from dietary interventions using bioactive foods to impact diseases of the liver and gastrointestinal system, including reduction of inflammation, improved function, and nutritional efficiency Presents a wide range of liver and gastrointestinal diseases and provides important information for additional research Associated information can be used to understand other diseases, which share common etiological pathways
Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 012814467X
Category : Science
Languages : en
Pages : 428
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Book Description
Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. Provides information on agents that affect metabolism and other health-related conditions in the liver Explores the impact of composition, including differences based on country of origin and processing techniques Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function
Author: Paul G. Winyard
Publisher: Springer Science & Business Media
ISBN: 1592593747
Category : Medical
Languages : en
Pages : 373
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Book Description
Inflammation has been described as the basis of many pathologies of human disease. When one considers the updated signs of inflammation, they would be vasodilation, cell migration, and, in the case of chronic inflam- tion, cell proliferation, often with an underlying autoimmune basis. Gen- ally, inflammation may be divided into acute, chronic, and autoimmune, - though the editors believe that most, if not all, chronic states are often the result of an autoimmune response to an endogenous antigen. Thus, a proper understanding of the inflammatory basis may provide clues to new therap- tic targets not only in classical inflammatory diseases, but atherosclerosis, cancer, and ischemic heart disease as well. The lack of advances in classical inflammatory diseases, such as rh- matoid arthritis, may in part arise from a failure to classify the disease into different forms. That different forms exist is exemplified in patients with d- fering responses to existing antiinflammatory drugs, ranging from nonresponders to very positive responders for a particular nonsteroidal an- inflammatory drug (NSAID). Though researchers have progressively unr- eled the mechanisms, the story is far from complete. It should also be noted that the inflammatory response is part of the innate immune response, or to use John Hunter’s words in 1795, “inflammation is a salutary response.” That may be applied in particular to the defensive response to invading micro- ganisms.
Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781719520
Category : Medical
Languages : en
Pages : 848
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Book Description
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
