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Author: Antoine Defour
Publisher:
ISBN:
Category :
Languages : fr
Pages : 208
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Book Description
La démarche d'optimisation de la production dans le domaine de l'industrie pharmaceutique est en cours seulement depuis une quinzaine d'année, celle-ci a longtemps profité de ces blockbusters qui lui apportaient des revenus conséquents. Cependant le marché de la concurrence a rapidement changé avec l'arrivée des génériques et le développement des biotechnologies nécessitant de lourds investissements. En plus du durcissement des mesures réglementaires, ces conséquences ont poussé les industries du médicament à développer des méthodes industrielles plus modernes. Le Lean et le Supply chain management font partis de ces outils, ils ont pu être mis en pratique durant ces 6 mois de mission industrielle. Cette étude a permis de mettre en évidence l'importance d'une bonne cohésion entre les services pour la résolution de problèmes avec comme exemple : l'impact des fiches d'anomalie sur la production, la supply chain ou encore l'assurance qualité. Les nombreux points communs entre les bonnes pratiques réglementaires et la philosophie Lean ont été mis en exergue durant ce travail, ainsi la problématique traitée a été résolue : le contexte réglementaire contraint n'est pas un frein à l'implémentation de projets d'amélioration.
Author: Antoine Defour
Publisher:
ISBN:
Category :
Languages : fr
Pages : 208
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Book Description
La démarche d'optimisation de la production dans le domaine de l'industrie pharmaceutique est en cours seulement depuis une quinzaine d'année, celle-ci a longtemps profité de ces blockbusters qui lui apportaient des revenus conséquents. Cependant le marché de la concurrence a rapidement changé avec l'arrivée des génériques et le développement des biotechnologies nécessitant de lourds investissements. En plus du durcissement des mesures réglementaires, ces conséquences ont poussé les industries du médicament à développer des méthodes industrielles plus modernes. Le Lean et le Supply chain management font partis de ces outils, ils ont pu être mis en pratique durant ces 6 mois de mission industrielle. Cette étude a permis de mettre en évidence l'importance d'une bonne cohésion entre les services pour la résolution de problèmes avec comme exemple : l'impact des fiches d'anomalie sur la production, la supply chain ou encore l'assurance qualité. Les nombreux points communs entre les bonnes pratiques réglementaires et la philosophie Lean ont été mis en exergue durant ce travail, ainsi la problématique traitée a été résolue : le contexte réglementaire contraint n'est pas un frein à l'implémentation de projets d'amélioration.
Author: Blanche Tarditi
Publisher:
ISBN:
Category :
Languages : fr
Pages : 0
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Book Description
Dans un contexte de mondialisation et aujourd'hui de relocalisation des sociétés, avec de plus en plus de contrôles et de compétitivité, les entreprises du médicament doivent alors s'améliorer et innover toujours plus pour optimiser leurs coûts et donc leurs revenus. L'industrie pharmaceutique subit de nombreux changements depuis quelques années tels qu'un ralentissement de la productivité, la fin des brevets pour un grand nombre de molécules ou encore la pression concernant la négociation des prix des médicaments. Cela résulte en grande partie de l'augmentation de certains coûts en R&D, production ou qualité et à cette concurrence toujours plus forte avec le développement des génériques notamment. Afin de rester compétitifs, les industries sont donc forcées de réfléchir à des pistes d'optimisation de leurs coûts de manière continue et pérenne qui peuvent évidemment connaître des contraintes et des limites.
Author: David HouŽto
Publisher: Lulu.com
ISBN: 1291761152
Category : Reference
Languages : fr
Pages : 327
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Book Description
Le terme promotion de la santé en Afrique, près de 30 ans après l'adoption de la Charte d'Ottawa, continue d'avoir des connotations complètement hors du sens que lui confère cette charte. Cela n'est pas étonnant quand on sait que la notion de santé dans ce contexte africain équivaut à la lutte contre la maladie à travers les soins de santé dispensés par des professionnels de la santé dans des formations sanitaires et les hôpitaux. L'évolution que connait le continent depuis quelques décennies est de donner un peu plus de place à la communauté à travers les relais communautaires dans une participation communautaire vidée de son contenu, car le pouvoir n'est jamais passé entre les mains des communautés.C'est au vu de tout ceci que le présent ouvrage à sa raison d'être pour expliquer les fondements de l'autonomisation communautaire et de la promotion de la santé avec leur importance pour la région africaine en proie aux mauvais indicateurs de santé comparativement aux autres régions du monde.
Author: Frédéric Bourdier
Publisher: Centre for East and South-East Asian Studies Lund University
ISBN:
Category : AIDS (Disease)
Languages : en
Pages : 36
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Book Description
Author: Roy MacLeod
Publisher: Springer Science & Business Media
ISBN: 1402054904
Category : Science
Languages : en
Pages : 292
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Book Description
This book represents a first considered attempt to study the factors that conditioned industrial chemistry for war in 1914-18. Taking a comparative perspective, it reflects on the experience of France, Germany, Austria, Russia, Britain, Italy and Russia, and points to significant similarities and differences. It looks at changing patterns in the organisation of industry, and at the emerging symbiosis between science, industry and the military.
Author: Food and Agriculture Organization of the United Nations
Publisher: Food & Agriculture Org.
ISBN: 9789251045411
Category : Business & Economics
Languages : en
Pages : 20
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Book Description
The actual Code of conduct is also available (1996) (ISBN 9251038341).
Author: Linda Strande
Publisher: IWA Publishing
ISBN: 1780404735
Category : Technology & Engineering
Languages : en
Pages : 428
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Book Description
It is estimated that literally billions of residents in urban and peri-urban areas of Africa, Asia, and Latin America are served by onsite sanitation systems (e.g. various types of latrines and septic tanks). Until recently, the management of faecal sludge from these onsite systems has been grossly neglected, partially as a result of them being considered temporary solutions until sewer-based systems could be implemented. However, the perception of onsite or decentralized sanitation technologies for urban areas is gradually changing, and is increasingly being considered as long-term, sustainable options in urban areas, especially in low- and middle-income countries that lack sewer infrastructures. This is the first book dedicated to faecal sludge management. It compiles the current state of knowledge of the rapidly evolving field of faecal sludge management, and presents an integrated approach that includes technology, management, and planning based on Sandecs 20 years of experience in the field. Faecal Sludge Management: Systems Approach for Implementation and Operation addresses the organization of the entire faecal sludge management service chain, from the collection and transport of sludge, and the current state of knowledge of treatment options, to the final end use or disposal of treated sludge. The book also presents important factors to consider when evaluating and upscaling new treatment technology options. The book is designed for undergraduate and graduate students, and engineers and practitioners in the field who have some basic knowledge of environmental and/or wastewater engineering.
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
ISBN:
Category : Health & Fitness
Languages : en
Pages : 536
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Book Description
Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.
Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development
ISBN:
Category : Business & Economics
Languages : en
Pages : 220
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Book Description
Are OECD countries becoming more knowledge-based? Are they embracing the information economy? To what extent are innovation, science, technology and economies becoming global? What are the new growth industries and occupations? With over 160 indicators, 60% of them new to this edition, the volume provides a comprehensive picture of countries’ performance in the areas of science, technology and industry. It uses an improved classification of technology and knowledge-intensive industries. New indicators address emerging policy issues: international mobility of human capital, relative innovative performance as measured by patent families, skills in the information economy, diffusion of the Internet and electronic commerce. Resources devoted to innovation in emerging areas such as biotechnology, environment, health and information and communication technologies are measured for the first time. A new section on the information economy relies on the latest data from official sources. With the essential findings presented in bullet points and methodological notes on indicators and data sources, this publication combines statistical rigour with easy access and readability. An electronic version makes individual sections, an elaborate data appendix and links to the databases readily available. The electronic version also gives users “clickable” access to the data used in charts and figures. AREAS COVERED: New resources for the knowledge-based economy - Human capital and international mobility - R&D performance - Role of government and business in R&D and innovation - Science and innovation performance - Resources and infrastructure for the information economy - Diffusion of Internet technologies and electronic commerce - Contribution of the information and communication technologies to economic performance - International trade - Foreign direct investment - Strategic alliances and cross-border, mergers and acquisitions - Internationalisation of science and technology - Industrial structure and productivity growth - Technology and knowledge-intensive industries and their performance. FURTHER READING: OECD Science, Technology and Industry Outlook 2000; OECD Information Technology Outlook 2000; OECD Communications Outlook 2001; A New Economy: Beyond the Hype, 2001 (OECD ); OECD Main Science and Technology Indicators 2001/1 and STI Working Papers series available at http://www.oecd.org/dsti/sti/stat-ana/index.htm.
Author: Food and Agriculture Organization of the United Nations
Publisher: Food & Agriculture Org.
ISBN: 9789251039717
Category : Business & Economics
Languages : en
Pages : 52
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Book Description
Provides annotations to the Principles of Article 9 of the Code of Conduct for Responsible Fisheries. These annotations are meant to serve as general guidance, and should be taken as suggestions or observations intended to assist those interested in identifying their own criteria and options for actions, as well as partners for collaboration, in support of sustainable aquaculture development.
