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Author: David Hazell Clark
Publisher:
ISBN: 9780951040102
Category : Pharmacologists
Languages : en
Pages : 61
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Book Description
Author: David Hazell Clark
Publisher:
ISBN: 9780951040102
Category : Pharmacologists
Languages : en
Pages : 61
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Book Description
Author: C. Prüll
Publisher: Springer
ISBN: 0230583741
Category : Science
Languages : en
Pages : 248
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Book Description
The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the first to consider the idea from its 19th century origins in the work of John Newport Langley and Paul Ehrlich, to its development of during the 20th century and its current impact on drug discovery in the 21st century.
Author: Terry P. Kenakin
Publisher: Academic Press
ISBN: 008092333X
Category : Medical
Languages : en
Pages : 410
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Book Description
This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments.The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer. *New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. *Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member. *Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles.*Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.
Author: Terrence P. Kenakin
Publisher: Gulf Professional Publishing
ISBN: 9780124041615
Category : Chemicals
Languages : en
Pages : 234
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Book Description
This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know more about the basic theories, principles and practical applications of pharmacology.
Author: V.C. Medvei
Publisher: Springer Science & Business Media
ISBN: 9400973047
Category : Medical
Languages : en
Pages : 912
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Book Description
o history of endocrinology can be written without reference N to Sir Humphry Davy Rolleston, whose monumental study of the subject appeared in 1936 under the modest subtitle: The Endocrine Organs in Health and Disease with an Historical Review. It was based on the author's Fitzpatrick Lectures at the Royal College of Physicians of London in 1933 and 1934. The lectureship, which dates from 1901, is devoted to the History of Medicine. Rolleston's work as regards scholarship and delivery cannot be surpassed and will remain the solid basis for any further study. It is of interest to note that Rolleston gave the Fitzpatrick Lectures when he was 71 years of age and had his book published when he was 74. By that time he had achieved most of his professional aims and all the honours a distinguished medical career can offer (see Section II). He perceived clearly that endocrinology was "an enormous subject in a most active stage of growth", which "recently has received most valuable help from organic chemists, who have devoted much time to the elucidation of the structure, isolation and synthesis of the hormones". He remarked that the knowledge of endocrinology was expanding with extreme rapidity, and it has been suggested that in this respect it would appear to be itself influenced by a growth hormone. He continued: "Before 1890 there were comparatively few publications dealing with the ductless glands, but in 1913, A.
Author: M. O. Faruk Khan
Publisher: Bentham Science Publishers
ISBN: 1681086875
Category : Medical
Languages : en
Pages : 349
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Book Description
The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical basis of drug action. This first volume of the series is comprised of 8 chapters focusing on basic background information about medicinal chemistry. It takes a succinct and conceptual approach to introducing important fundamental concepts required for a clear understanding of various facets of pharmacotherapeutic agents, drug metabolism and important biosynthetic pathways that are relevant to drug action. Notable topics covered in this first volume include the scope and importance of medicinal chemistry in pharmacy education, a comprehensive discussion of the organic functional groups present in drugs, and information about four major types of biomolecules (proteins, carbohydrates, lipids, nucleic acids) and key heterocyclic ring systems. The concepts of acid-base chemistry and salt formation, and their applications to the drug action and design follow thereafter. These include concepts of solubility and lipid-water partition coefficient (LWPC), isosterism, stereochemical properties, mechanisms of drug action, drug receptor interactions critical for pharmacological responses of drugs, and much more. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body.
Author: Josef Donnerer
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805580045
Category : Medical
Languages : en
Pages : 226
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Book Description
Neurochemical transmission accounts for the majority of information transfer both in the central and peripheral nervous system. The initial findings centred around the experimental work of the two Nobel Prize winners Sir Henry H. Dale and Otto Loewi as well as Wilhelm Feldberg. Their historical findings opened the door to further investigations and extended the list of neurotransmitters to many others such as amino acids, peptides, purines and nitric oxide. In the first part, the publication provides fascinating insights into the life of the three scientists. Their personality and scientific approach are presented through autobiographical sketches and personal memories by authors. Various comments and details of the atmosphere in the laboratory complete the picture of the conditions at the time. The second part is dedicated to the history of the substances, such as neurotransmitters, their antagonists and analogues. The stories of these substances are presented to the reader in a succinct way, including many anecdotes and unusual events on the way to their therapeutic application. Contents Preface Introduction Otto Loewi Otto Loewi Introductory Remarks Autobiographic Sketch. By O. Loewi Otto Loewi 1873-1961. By H.H. Dale Otto Loewi. By F. Brucke Loewi's Time in Graz Comment on Loewi's Dream An Overlooked Parallel to Kekule's Dream: The Discovery of the Chemical Transmission of Nerve Impulses by Otto Loewi. By U. Weiss and R.A. Brown The Loewi Family's Way to the New World Comment on the Film Nobelpreistrager Otto Loewi Henry Hallett Dale Henry Hallett Dale Introductory Remarks Henry Hallett Dale 1875-1968. By W. Feldberg Fifty Years after the Nobel Prize Award to H.H. Dale and Otto Loewi. By G.B. Koelle Religious Reflections of Dale and Loewi Wilhelm Feldberg Wilhelm Feldberg Introductory Remarks The Early History of Synaptic and Neuromuscular Transmission by Acetylcholine: Reminiscences of an Eye Witness. By W. Feldberg From the History of Scientists to that of Neurotransmitters A Substance Isolated from Brain, Synthesized and Called Neurin: Acetylcholine Adrenaline, Noradrenaline and Dopamine: The Catecholamines Enteramine and Serotonin: Two Names and Three Functions of 5-Hydroxytryptamine Histamine: One Substance and Three Functions The Amino Acid Transmitter Family A Cloud of Peptides Substance P Calcitonin Gene-Related Peptide Neuropeptide, Galanine and Vasoactive Intephinal Polypeptide Opioid Peptides Nitric Oxide ATP and Adenosine Peripheral Neurogenic Stimulators Neurotransmission in the Central Nervous System From Transmitter to Receptor: Progress within 50 Years.
Author: Ole Peter Grell
Publisher: Routledge
ISBN: 1315521083
Category : History
Languages : en
Pages : 259
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Book Description
This is the first volume to take a broad historical sweep of the close relation between medicines and poisons in the Western tradition, and their interconnectedness. They are like two ends of a spectrum, for the same natural material can be medicine or poison, depending on the dose, and poisons can be transformed into medicines, while medicines can turn out to be poisons. The book looks at important moments in the history of the relationship between poisons and medicines in European history, from Roman times, with the Greek physician Galen, through the Renaissance and the maverick physician Paracelsus, to the present, when poisons are actively being turned into beneficial medicines. Chapter 5 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
Author: Jonathan Herring
Publisher: Bloomsbury Publishing
ISBN: 1509958746
Category : Law
Languages : en
Pages : 314
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Book Description
Intoxicants, substances that alter a person's mental and physiological state, are a continuing obsession. In their effect on the mind and body, intoxicants go to the heart of what it means to be human. In the tensions between 'free' and uninhibited consumption on the one hand, and the pressures of social regulation and personal responsibility on the other, they also illuminate the daily paradoxes, and sheer complexity, of living in modern Western societies. Yet this complexity, and the rich history that underpins it, is often lost in the current debates over public policy. Intoxication and Society sets out to supplement the contemporary discourse surrounding intoxication with a more nuanced appreciation of the history and nature of what is very much a multidimensional problem. It does so by employing an interdisciplinary framework that includes contributions from leading academics in law, sociology, anthropology, history, literature, neuroscience and social psychology. The result is a subtle historical and contemporary rereading of the social construction of intoxication that will provide a secure basis for analysis as society continues to respond to the problematic pleasures of intoxication.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 932
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Book Description
Includes subject section, name section, and 1968-1970, technical reports.
