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Author: Miral Dizdaroglu
Publisher: Springer Science & Business Media
ISBN: 1461548659
Category : Science
Languages : en
Pages : 502
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Book Description
In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.
Author: Miral Dizdaroglu
Publisher: Springer Science & Business Media
ISBN: 1461548659
Category : Science
Languages : en
Pages : 502
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Book Description
In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.
Author: Clark Chen
Publisher: BoD – Books on Demand
ISBN: 9535122096
Category : Medical
Languages : en
Pages : 498
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Book Description
This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.
Author: Miral Dizdaroglu
Publisher: Springer
ISBN: 9781461548669
Category : Science
Languages : en
Pages : 511
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Book Description
In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.
Author: Jac A. Nickoloff
Publisher: Springer Science & Business Media
ISBN: 1592590950
Category : Science
Languages : en
Pages : 417
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Book Description
Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.
Author: Kum Kum Khanna
Publisher: Springer Science & Business Media
ISBN: 9048125618
Category : Medical
Languages : en
Pages : 450
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Book Description
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.
Author: Errol C. Friedberg
Publisher: American Society for Microbiology Press
ISBN: 1555813194
Category : Science
Languages : en
Pages : 2587
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Book Description
An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Jac A. Nickoloff
Publisher: Springer Science & Business Media
ISBN: 1592594557
Category : Science
Languages : en
Pages : 1050
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Book Description
Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.
Author: G.P. Pfeifer
Publisher: Springer Science & Business Media
ISBN: 9780306452376
Category : Medical
Languages : en
Pages : 476
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Book Description
''Useful and timely.'' ---Mutagenesis ''Of considerable value.'' ---Journal of Medical Genetics ''Quite readable....a comprehensive overview....perfectly covers the needs of those researchers who have to decide on the best strategy to identify damage or mutations at the molecular level.'' ---Trends in Cell Biology ''The formats of the presentations are uniform and ample and up-to-date references are provided at the end of each chapter...will be welcomed by postgraduate researchers of all ages and should retain its usefulness for a long time.'' ---Endeavour, 21(4), 1997 This important resource thoroughly reviews a wide range of techniques used in mutagenesis research-ranging from established techniques to recently developed methodologies-based on the polymerase chain reaction. DNA damage analysis, DNA repair assays, and mutation detection are a few of the techniques featured. Chapters present detailed experimental protocols benefiting researchers and students in the fields of toxicology, biotechniques, molecular biology, photobiology, medical genetics, and oncology.
Author: Inna Kruman
Publisher: BoD – Books on Demand
ISBN: 9533076976
Category : Medical
Languages : en
Pages : 652
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Book Description
The book consists of 31 chapters, divided into six parts. Each chapter is written by one or several experts in the corresponding area. The scope of the book varies from the DNA damage response and DNA repair mechanisms to evolutionary aspects of DNA repair, providing a snapshot of current understanding of the DNA repair processes. A collection of articles presented by active and laboratory-based investigators provides a clear understanding of the recent advances in the field of DNA repair.
