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Author:
Publisher: Academic Press
ISBN: 0123849225
Category : Science
Languages : en
Pages : 257
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Book Description
This volume of Current Topics in Membranes focuses on adrenergic receptor biology, beginning with a review of past successes and historical perspectives then further discussing current general trends in adrenic receptor studies in various contexts. This publication also includes discussions of the role and relationship of adrenergic receptors to different systems and diseases, establishing adrenergic receptor biology as a needed, practical reference for researchers.
Author:
Publisher: Academic Press
ISBN: 0123849225
Category : Science
Languages : en
Pages : 257
Get Book Here
Book Description
This volume of Current Topics in Membranes focuses on adrenergic receptor biology, beginning with a review of past successes and historical perspectives then further discussing current general trends in adrenic receptor studies in various contexts. This publication also includes discussions of the role and relationship of adrenergic receptors to different systems and diseases, establishing adrenergic receptor biology as a needed, practical reference for researchers.
Author:
Publisher: ScholarlyEditions
ISBN: 1481619985
Category : Medical
Languages : en
Pages : 46
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Book Description
Adrenergic Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Adrenergic Receptors in a concise format. The editors have built Adrenergic Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher: ScholarlyEditions
ISBN: 1481642006
Category : Science
Languages : en
Pages : 18
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Book Description
beta Adrenergic Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about beta Adrenergic Receptors in a compact format. The editors have built beta Adrenergic Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about beta Adrenergic Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of beta Adrenergic Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher: ScholarlyEditions
ISBN: 1481617087
Category : Medical
Languages : en
Pages : 49
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Book Description
Adrenergic beta Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Adrenergic beta Receptors in a concise format. The editors have built Adrenergic beta Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic beta Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic beta Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher: ScholarlyEditions
ISBN: 1481632663
Category : Medical
Languages : en
Pages : 25
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Book Description
Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adrenergic alpha Receptors in a compact format. The editors have built Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic alpha Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic alpha Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher: ScholarlyEditions
ISBN: 1464944571
Category : Medical
Languages : en
Pages : 39
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Book Description
Adrenergic Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adrenergic Receptors in a compact format. The editors have built Adrenergic Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher: ScholarlyEditions
ISBN: 1481637290
Category : Medical
Languages : en
Pages : 22
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Book Description
beta-Adrenergic Receptor Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about beta-Adrenergic Receptor Kinases in a compact format. The editors have built beta-Adrenergic Receptor Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about beta-Adrenergic Receptor Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of beta-Adrenergic Receptor Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author:
Publisher: ScholarlyEditions
ISBN: 1481681524
Category : Medical
Languages : en
Pages : 90
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Book Description
Adrenergic Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Adrenergic alpha Receptors in a concise format. The editors have built Adrenergic Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenergic alpha Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenergic Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Dianne M. Perez
Publisher: Springer Science & Business Media
ISBN: 1592599311
Category : Medical
Languages : en
Pages : 402
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Book Description
An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
Author: Christopher B. Roth
Publisher:
ISBN:
Category : Beta adrenoceptors
Languages : en
Pages : 204
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Book Description
G-protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, accounting for >1% of the human genome and are the target of more than 30% of currently marketed pharmaceuticals. Although structural information is vital to the thorough understanding of this important class of receptors, progress has been greatly limited by the instability of these molecules in the detergent solutions used for their extraction, purification, and crystallization. To surmount this obstacle, we developed an engineering strategy where targeted amino acid substitutions were introduced at transmembrane helix (TM) interfaces in order to stabilize the receptor core fold, while at the same time maintaining normal receptor biochemistry. In the first chapter, background information on GPCR phylogeny, structure, and mechanism is reviewed. In the second chapter, the development of technology and methods for characterizing engineered [beta]-adrenergic receptors is described, including a high throughput flow-cytometric determination of receptor expression, and a novel HPLC-based system for rapid screening of receptor aggregation state and thermal stability. In the third chapter, the discovery of a stabilized mutant of the [beta]2-adrenergic receptor ([beta]2AR) is described where mutation of Glu-1223·41 to tryptophan resulted in a dramatic increase in receptor thermal stability while preserving near wild-type biochemistry and may do so by stabilizing the conserved break in TM5 at Pro-2115·50 . In the final chapter, agonist docking studies were performed using the recently published [beta]2AR X-ray crystal structure, which revealed that flexibility in TM5 is critical to the full engagement of key agonist-binding residues in TM3, TM5, TM6 and TM7, and may be an early step in the GPCR activation mechanism.
