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Author: Emmanuel Jouanneau
Publisher: Springer Nature
ISBN: 3030411761
Category : Medical
Languages : en
Pages : 233
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Book Description
This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.
Author: Emmanuel Jouanneau
Publisher: Springer Nature
ISBN: 3030411761
Category : Medical
Languages : en
Pages : 233
Get Book Here
Book Description
This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.
Author: Juan Pedro Martinez-Barbera
Publisher: Springer
ISBN: 3319518909
Category : Medical
Languages : en
Pages : 223
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Book Description
This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
Author: Songtao Qi
Publisher: Bentham Science Publishers
ISBN: 1681085321
Category : Medical
Languages : en
Pages : 437
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Book Description
Craniopharyngiomas are a type of brain tumour in the suprasellar region with benign histological and cellular features. Clinical manifestations of craniopharyngiomas include decreased vision, hypopituitarism, hypothalamus dysfunction, fluid and electrolyte imbalance, glycometabolism, lipid metabolism and obesity. Craniopharyngiomas can show some characteristics of malignant tumours, such as invasion to the surrounding tissues, repetitious recurrence, and rapid growth. These characteristics cause considerable difficulty in patient treatment for neurosurgeons all over the world. This volume presents detailed information about craniopharyngioma anatomy, classification and treatment.
Author: Supriya Mallick
Publisher: Springer
ISBN: 9789811626616
Category : Medical
Languages : en
Pages : 0
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Book Description
This book provides evidence-based management in neuro-oncology covering all aspects such as pathology, radiology, surgery, radiation, and chemotherapy.The field of neuro-oncology is rapidly evolving and new evidence is coming out every day towards the optimal management of brain tumors. This necessitates a requirement of a complete guide that shall provide an evidence-based and personalized approach towards dealing with patients. This book also covers recent advances in personalized treatment formed through the relevant basis of anatomy, imaging, radiology, surgical, radiation and systemic treatment of brain and spinal tumors. In addition it also covers the , practical aspects of the planning of the Gamma knife and other radio surgical aspects. The book shall provide valuable assistance to practicing neuro-oncologists to practice better evidence-based personalized medicine.
Author: Hermann L. Mueller
Publisher: Frontiers E-books
ISBN: 2889190617
Category :
Languages : en
Pages : 91
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Book Description
Craniopharyngiomas are benign, partly cystic embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium. With an overall incidence of 0.5–2 new cases per million population per year, approximately 30-50% of all cases represent childhood craniopharyngioma. Typical manifestations at primary diagnosis are headache, visual impairment, polyuria/polydypsia, growth retardation, and weight gain. One of the biggest challenges in treating craniopharyngioma is identifying the best candidates for the radical versus the conservative approach. It appears there is a trend towards radiotherapy in centers with past prevalent surgical approaches, and towards more radical surgical treatment strategies in centers historically conservative-oriented. There are current prospective studies underway on a national and multinational level to adopt strategies tailored to risk factors for morbidity and QOL. Therapy of choice in patients with favorable tumor localization is total resection with the intention to maintain optical nerve and hypothalamic-pituitary functions. In patients with unfavorable tumor localization (hypothalamic tumor involvement), a limited resection followed by local irradiation is recommended. The overall survival rates are high (92%). Recurrences after complete resection and progressions of residual tumor after incomplete resection are anticipated subsequent events after primary surgery. In clinical practice, the timing of postoperative residual tumor irradiation is both unclear and inconsistently regarded. Some favor immediate postoperative irradiation in the event of life-impairing clinical conditions, proactively preventing tumor progression. On the other hand, some favor a wait-and-see procedure, delaying irradiation in order to reduce both its necessity and the negative consequences associated with radiation therapy. Inarguably, immediate postoperative irradiation significantly delays tumor progression. However, progression-contingent irradiation has proved effective, as overall survival is statistically unaffected by this wait-and-see strategy. Accordingly, the appropriate time point of irradiation after incomplete resection is currently under investigation in a randomized trial (KRANIOPHARYNGEOM 2007). Quality of life is substantially reduced in appr. 50% of long-term survivors due to sequelae, notably extreme obesity due to hypothalamic involvement. Due to the lack of satisfactory long-term treatment modalities for hypothalamic sequelae, further research on molecular characteristics of craniopharyngioma, pathophysiology of hypothalamic disorders, and pharmaceutical agents to treat hypothalamic obesity are warranted. Risk-adapted surgical strategies at initial diagnosis should aim at a maximal degree of resection, respecting the integrity of optical and hypothalamic structures in order to prevent severe sequelae and therein minimizing consequences that could negative impact patient QOL. Because initial hypothalamic tumor involvement has an apriori effect on the clinical course, childhood craniopharyngioma should be recognized as a chronic disease requiring constant monitoring of the consequences and medical resources for treatment in order to provide not only optimal QOL for patients, but also to garner additional information with the intent of minimizing what at present are severe consequences of both the disease and its treatment.
Author: Lia M. Halasz
Publisher: Springer Nature
ISBN: 3030645088
Category : Medical
Languages : en
Pages : 208
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Book Description
This book is a practical, up-to-date guide to the treatment of patients with brain and spinal tumors. Leading experts in the field explain treatment techniques in detail, highlighting key considerations in the use of external beam radiation therapy, intensity-modulated radiation therapy, particle therapy, radiosurgery, and stereotactic body radiation therapy. Specific recommendations are described for different tumor types, and helpful information provided on other important issues, such as the interaction of radiotherapy and systemic therapy and the avoidance of treatment complications. With the development of modern technology, highly conformal radiotherapy techniques have become more complicated, yet also more widely employed. This book will equip readers with the knowledge required to set up practices to deliver quality brain and spinal radiation therapy appropriate to each patient. It will be of benefit to radiation oncologists, clinical oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses as well as medical oncologists and surgical oncologists with an interest in radiotherapy.
Author: Helen Turner
Publisher: Oxford University Press, USA
ISBN: 0198567391
Category : Medical
Languages : en
Pages : 954
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Book Description
This handbook in endocrinology and diabetes discusses clinical investigation and management in a convenient way, including both the protocols and explicit clinical information necessary for the management of individual patients.
Author: F. Allan Midyett
Publisher: Springer Nature
ISBN: 3030464474
Category : Medical
Languages : en
Pages : 374
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Book Description
This book is a comprehensive guide to skull base imaging. Skull base is often a “no man’s land” that requires treatment using a team approach between neurosurgeons, head and neck surgeons, vascular interventionalists, radiotherapists, chemotherapists, and other professionals. Imaging of the skull base can be challenging because of its intricate anatomy and the broad breadth of presenting pathology. Although considerably complex, the anatomy is comparatively constant, while presenting pathologic entities may be encountered at myriad stages. Many of the pathologic processes that involve the skull base are rare, causing the average clinician to require help with their diagnosis and treatment. But, before any treatment can begin, these patients must come to imaging and receive the best test to establish the correct diagnosis and make important decisions regarding management and treatment. This book provides a guide to neuoradiologists performing that imaging and as a reference for related physicians and surgeons. The book is divided into nine sections: Pituitary Region, Cerebellopontine Angle, Anterior Cranial Fossa, Middle Cranial Fossa, Craniovertebral Junction, Posterior Cranial Fossa, Inflammatory, Sarcomas, and Anatomy. Within each section, either common findings in those skull areas or different types of sarcomas or inflammatory conditions and their imaging are detailed. The anatomy section gives examples of normal anatomy from which to compare findings against. All current imaging techniques are covered, including: CT, MRI, US, angiography, CT cisternography, nuclear medicine and plain film radiography. Each chapter additionally includes key points, classic clues, incidence, differential diagnosis, recommended treatment, and prognosis. Skull Base Imaging provides a clear and concise reference for all physicians who encounter patients with these complex and relatively rare maladies.
Author: Kathreena M. Kurian
Publisher: Cambridge University Press
ISBN: 1107038162
Category : Medical
Languages : en
Pages : 243
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Book Description
Unparalleled access to the entire central nervous system with over four hundred gross neuropathology images from adult and paediatric post-mortem tissues.
Author: Meghana Chougule
Publisher: Springer Nature
ISBN: 9811571260
Category : Medical
Languages : en
Pages : 364
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Book Description
This highly illustrated book explores the pathological and radiological diagnosis of various brain tumors. Featuring nearly 500 high-quality colored images, it covers MR images, intra-operative squash cytology, histopathology and immunohistochemistry microphotographs of various brain and spine tumors, including differential diagnosis, as well as the molecular diagnosis and prognosis of each tumor. The book also presents case studies of typical and rare presentations, and introduces readers to a new procedure for intra-operative cytology: the modified fields stain, which stains the slide within 2 minutes, allowing quick, accurate reporting. This book uses concise text and a consistent point-wise format that makes reading and reviewing easy. The radiological and pathological correlates of brain and spine tumors serve as a ready-reference resource for residents, surgical and neuropathologists, neuroradiologists, neurosurgeons, neuro-oncologists and research scientists.
