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Author:
Publisher: BoD – Books on Demand
ISBN: 1838802037
Category : Science
Languages : en
Pages : 86
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Book Description
This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.
Author:
Publisher: BoD – Books on Demand
ISBN: 1838802037
Category : Science
Languages : en
Pages : 86
Get Book
Book Description
This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.
Author: Gyula Mozsik
Publisher:
ISBN: 9781838802042
Category : Biology (General)
Languages : en
Pages : 84
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Book Description
This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.
Author: Evgenia Gerasimovskaya
Publisher:
ISBN: 9789048134519
Category :
Languages : en
Pages : 250
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Book Description
Author: Evgenia Gerasimovskaya
Publisher: Springer Science & Business Media
ISBN: 9048134358
Category : Science
Languages : en
Pages : 240
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Book Description
Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.
Author: Eric Boué-Grabot
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Adenosine 5'-triphosphate (ATP) is one of the most abundant molecule in living cells serving as universal energy "currency." After slow acceptance of the concept of the release and extracellular action of ATP, purinergic signaling is recognized as a widespread mechanism for cell-to-cell communication in living organisms. Additionally, the contribution of pyrimidine nucleotides (such as UTP and UDP) and sugar-nucleotides (i.e., UDP-glucose and UDP-galactose) have been more recently discovered. Purinergic signaling plays major physiological roles in mammalian central nervous system (CNS) such as neurotransmission, neuromodulation, communication in glial network and between neurons and glia. Extracellular ATP and its metabolic breakdown is a source of other nucleotides and adenosine providing the versatile basis for complex purinergic signaling through the activation of several families of purinergic receptors. G-protein coupled P1 receptors for adenosine, ionotropic P2X receptors for ATP and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in central neurons at pre-and post-synapse and in glial cells. Alterations of purinergic signals are associated with major CNS disorders including chronic pain, brain trauma ischemia, epilepsy, neurodegenerative diseases such as Alzheimer disease or Amyotrophic lateral sclerosis associated with neuro-inflammation as well as neuropsychiatric diseases, including depression, anxiety and schizophrenia.
Author: Lawrence H. Lash
Publisher: Elsevier
ISBN: 1483218619
Category : Science
Languages : en
Pages : 527
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Book Description
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author: Shaul Massry
Publisher: Springer Science & Business Media
ISBN: 1461342171
Category : Medical
Languages : en
Pages : 611
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Book Description
We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Author: Patrick F. Chinnery
Publisher: Cambridge University Press
ISBN: 0521132983
Category : Medical
Languages : en
Pages : 229
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Book Description
This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.
Author: David D. Tyler
Publisher:
ISBN:
Category : Mitochondria
Languages : en
Pages : 584
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Book Description
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
