Studies in Acyclic Stereoselection PDF Download
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Author: Michael S. VanNieuwenhze
Publisher:
ISBN:
Category :
Languages : en
Pages : 530
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Author: Bruce Lawrence Finkelstein
Publisher:
ISBN:
Category :
Languages : en
Pages : 312
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Author: Edward Meredith Burgess
Publisher:
ISBN:
Category : Stereochemistry
Languages : en
Pages : 8
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Author: Mihály Nógrádi
Publisher: John Wiley & Sons
ISBN: 3527615687
Category : Science
Languages : en
Pages : 386
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Book Description
The state-of-the-art in stereoselective synthesis! Thoroughly revised and updated, this enlarged second edition offers a plethora of valuable information on methods and reagents in stereoselective synthesis. Methods have been selected for high efficiency and selectivity; mechanistic aspects are treated succinctly, with a strong emphasis on practical applications. For this new edition, material has been added on * homogeneous diastereoselective hydrogenations * enantioselective oxidations * novel, efficient chiral auxiliaries Much of the information given is presented in figures and tables, which makes the book a valuable reference work for the practically minded organic chemist. From reviews of the first edition: 'The extensive material in the volume should prove particularly useful to anyone involved in synthetic chemistry or teaching a course in organic chemistry.' Journal of Medicinal Chemistry 'With nearly 1400 references cited, the book contains a wealth of information and should be a useful addition to the chemist's library.' The American Scientist
Author: Young Gyu Kim
Publisher:
ISBN:
Category : Heterocyclic compounds
Languages : en
Pages : 540
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Author: Mark Alan Henderson
Publisher:
ISBN:
Category :
Languages : en
Pages : 574
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Author: Rainer Mahrwald
Publisher: John Wiley & Sons
ISBN: 3527656731
Category : Science
Languages : en
Pages : 604
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Book Description
The selective formation of bondings between molecules is one of the major challenges in organic chemistry, and the so-called aldol reaction is one of the most important for this purpose. These reactions are a highly useful tool for developing such novel substances as natural products and pharmaceuticals. Likes its highly successful and much appreciated predecessor, "Modern Aldol Reactions", this ready reference provides a systematic overview of methodologies for installing a required configuration during an aldol addition step, but shifts the focus so as to cover the latest developments. As such, it presents a set of brand new tools, including vinylogous Mukaiyama-aldol reactions and substrate-controlled aldol reactions, as well as asymmetric induction in aldol additions. Furthermore, new developments in existing stereoselective aldol additions are described, such as the deployment of supersilyl groups or organocatalyzed aldol additions. All of these methodologies are presented in the context of their deployment in the total synthesis of natural products.
Author: B. S. Balaji
Publisher: CRC Press
ISBN: 1040097553
Category : Science
Languages : en
Pages : 267
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Book Description
To understand and improve the underlying principles that govern how organic reactions occur, A Foundation Course for College Organic Chemistry follows a brick-by-brick building approach. Emphasis is given to interrelating experimental facts and findings with predictions (mechanism) and inferences (results). Discussions focus on clarifying how complex organic reactions occur, which is based on electronegativity differences, movement of electrons (through σ framework or π bonds), and addition or removal of atoms (hydrogen, halogens) or groups (hydroxy, amino). The book begins with simple rules governing the deconstruction of reactions and applies them to explain how esterification, amide, and cyanide hydrolysis reactions proceed. The importance of stereochemistry (used in drug development, biology, and medicine), aromatic electrophilic and nucleophilic substitutions, reaction kinetics, and dynamics is explained with suitable examples. Features: A systematic and structured approach is used to study all aspects of reactive intermediates (generation, structure, geometry, and reactions of carbocations, carbanions, and carbon-free radicals) This book incorporates scientific methods to deduce reaction mechanisms with simple and relevant explanations, and limitations A proper explanation is given to understand the influence of functional groups on the stability and reactivity of intermediates, pKa, HSAB principles, structure-activity relations, and how these can be exploited in organic chemistry Information is presented in an accessible way for students, teachers, researchers, and scientists
Author: Michael S. VanNieuwenhze
Publisher:
ISBN:
Category :
Languages : en
Pages : 530
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Book Description
Author: Vasyl Andrushko
Publisher: John Wiley & Sons
ISBN: 1118628330
Category : Science
Languages : en
Pages : 1836
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Book Description
Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.
![Acyclic Stereoselection in [alpha]-amidoalkylation Reactions PDF](https://books.google.com/books/content/images/frontcover/Z2uxNwAACAAJ?fife=w80-h100)
Author: Clark Steven Davis
Publisher:
ISBN:
Category : Amino acids
Languages : en
Pages : 228
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Book Description
