Author: E. Ramon-Moliner
Publisher: Springer Science & Business Media
ISBN: 3642500552
Category : Medical
Languages : en
Pages : 53
Get Book Here
Book Description
The earliest studies on the regional distribution of acetylcholinesterase (AChE) within the central nervous system were based on the determination of the amount of CO liberated by homogenates of selected areas in the presence of an ester of 2 choline and a bicarbonate buffer. Using this biochemical approach, Burgen and Chipman (1951) were able to establish that acetylcholinesterase is not evenly distributed within the central nervous system. They found that the cerebellum, the lateral geniculate body, and the striatum contained a high concentration of AChE. The high concentration of AChE in the striatum could be correlated with a higher rate of acetylcholine synthesis. However, this was not the case for the cerebellum, where acetylcholine synthesis was very low. Other in vitro studies have been aimed at establishing the regional distribution of the other two components of the cholinergic system, cholinacetylase (ChA) and acetylcholine (ACh). An equally asymetrical distribution for these substances has been established in vitro (MacIntosh, 1941 ; Feldberg and Mann, 1946; Feldberg and V ogt, 1948; MacIntosh and Oborin, 1953; Quastel, 1962; Mitchell, 1963; Krnjevic and Phillis, 1963; Aprison et al., 1964; McLennan, 1964; Cohen, 1956). The in vitro determination of acetylcholinesterase (Koelle, 1950; Burgen and Chipman, 1951; Giacobini, 1959; Bennett et al., 1966; Fahn and Cote, 1968; Miller et al., 1969) presents the advan tage of permitting the use of a substrate like ACh which is a normally occurring ester of choline so that the establishment of enzyme specificity is less questionable.
Author: E. Ramon-Moliner
Publisher:
ISBN: 9783642500565
Category :
Languages : en
Pages : 56
Get Book Here
Book Description
Author: Enrique Ramon-Moliner
Publisher: Springer
ISBN:
Category : Acetylcholinesterase
Languages : en
Pages : 58
Get Book Here
Book Description
Author: Library of Congress. Copyright Office
Publisher: Copyright Office, Library of Congress
ISBN:
Category : Copyright
Languages : en
Pages : 1862
Get Book Here
Book Description
Author: Rodolfo Llinas
Publisher: Springer Science & Business Media
ISBN: 1461228409
Category : Medical
Languages : en
Pages : 354
Get Book Here
Book Description
This book is organized into three parts that correspond with the main groups of chapters delivered during the Cajal Centenary Meeting on The Neutron Doctrine. These chapters represent important aspects of the morphology, development, and function of the cerebellum and related structures. Clearly an exhaustive analysis of all aspects of the cerebellar system, as they relate to the legacy of Ramon y Cajal, would be impossible to contain in just one volume, given its far-reaching impact. Instead, we deliberately steered away from the traditional handbook approach that some of us have taken in the past and selected those aspects of cerebellar research currently under vigorous study that would also represent the widest scope of interest for neuroscientists in general and for cerebellar specialists in particular. In particular, we felt that as the discrete anatomy of the cerebellum is quite well known, only certain aspects of the structure should be discussed here. For example, the organization of the pontocerebellar pathways, we felt, would be particularly interesting given the enormity of the system in higher vertebrates. Also of interest is the distribution and development of the synaptology and neurotransmitter properties in this cortex. Indeed, from the point of view of cerebellar development, this may represent one of the clearest paradigms in the understanding of rules for neurogenesis for the central nervous system.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1504
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 522
Get Book Here
Book Description
Intended as annual listing of medical and paramedical books, cassette tapes, and films, currently available for the continuing education of physicians. Information provided by book publishers. Arranged by specialties. Entries include bibliographical data, Library of Congress number, price, and many annotations. Author index, list of pharmaceutical companies and addresses.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1380
Get Book Here
Book Description
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 80
Get Book Here
Book Description
First multi-year cumulation covers six years: 1965-70.
Author: National Agricultural Library (U.S.)
Publisher:
ISBN:
Category : Agriculture
Languages : en
Pages : 688
Get Book Here
Book Description
