Applied Biopharmaceutics and Pharmacokinetics PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Applied Biopharmaceutics and Pharmacokinetics PDF full book. Access full book title Applied Biopharmaceutics and Pharmacokinetics by Leon Shargel. Download full books in PDF and EPUB format.
Author: Leon Shargel
Publisher: McGraw-Hill/Appleton & Lange
ISBN: 9780838502396
Category : Biopharmaceutics
Languages : en
Pages : 625
Get Book Here
Book Description
Author: Leon Shargel
Publisher: McGraw-Hill/Appleton & Lange
ISBN: 9780838502396
Category : Biopharmaceutics
Languages : en
Pages : 625
Get Book Here
Book Description
Author: Panos Macheras
Publisher: Springer Science & Business Media
ISBN: 0387319107
Category : Mathematics
Languages : en
Pages : 446
Get Book Here
Book Description
This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
Author: Notari
Publisher: CRC Press
ISBN: 9780824775230
Category : Science
Languages : en
Pages : 448
Get Book Here
Book Description
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface to the Fourth Edition -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Nomenclature -- 1: Introduction -- References -- 2: Rates, Rate Constants, and Order -- I. Order -- II. Rates and Rate Constants -- 3: Active and Passive Transport -- I. Introduction -- II. Passive Transport -- III. Active Transport -- References -- 4: Pharmacokinetics -- I. Introduction -- II. Drug Disposition -- III. Constant-Rate Intravenous Infusion -- IV. Compartmental Models and Their Limitations -- V. Absorption Rate Constants -- References -- 5: Biopharmaccutics -- I. Extravascular Administration -- II. Absorption of Drugs from the Gastrointestinal Tract -- III. Factors Influencing Bioavailability -- IV. Evaluation of the Bioavailability of a Single Drug -- V. Drug Delivery to Prolong Duration -- References -- 6: Dosage Regimens -- I. Introduction -- II. Accumulation During Repetitive Dosing -- III. Adjustment of Dosage Regimen in Renal Failure -- IV. Multiple Dosing of Constant-Rate Intravenous Infusions -- References -- 7: Pharmacokinetic Aspects of Structural Modifications in Drug Design and Therapy -- I. Introduction -- II. Antimicrobial Agents -- III. Pharmacokinetics of Prodrugs -- IV. Stereoisomers -- References -- 8: Pharmacokinetic Applications in Clinical Practice -- I. Introduction -- II. Pharmacokinetic Drug Interactions -- III. Clinical Pharmacokinetics -- References -- Appendix -- Index
Author: Sarfaraz Niazi
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 364
Get Book Here
Book Description
Author: Milo Gibaldi
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 196
Get Book Here
Book Description
Author: V. Venkateswarlu
Publisher: Pharmamed Press
ISBN: 9789352300532
Category : Medical
Languages : en
Pages : 530
Get Book Here
Book Description
This book deals with the basics of the two disciplines of biopharmaceutics and pharmacokinetics. Different factors such as biological, physiochemical and formulation that influence the therapeutic efficacy of a drug are covered in biopharmaceutics. The absorption, distribution, metabolism and excretion of drugs are studied under this subject. Salient Features - Basics of biopharmaceutics and pharmacokinetics help to understand the various procedures and advances in drug design, product development, therapeutic drug monitoring, etc. - Pharmacokinetics covers the fundamentals of one compartment open model, multi-compartmental models. One compartment open model is presented in an elaborate manner to make the students familiar with various aspects of pharmacokinetics - Mathematical equations are developed using simple integration and differentiation methods - Practice problems are provided wherever necessary, and a question bank is included at the end of each chapter - Extreme care has been exercised to present the concepts in a simple way Second Edition includes - Application of principles in formulation development in industry for successful bioequivalence studies is included - One chapter on "In-vitro Dissolution Testing" is included to evaluate test formulations to chose right product for bioequivalence studies - A chapter on biostatistics with practice problems is included
Author: Rajesh Krishna
Publisher: Springer Science & Business Media
ISBN: 038772379X
Category : Medical
Languages : en
Pages : 416
Get Book Here
Book Description
The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.
Author: Dr. A. R. Paradkar
Publisher: Pragati Books Pvt. Ltd.
ISBN: 9788185790374
Category :
Languages : en
Pages : 198
Get Book Here
Book Description
Author: Bernd Meibohm
Publisher: John Wiley & Sons
ISBN: 3527609520
Category : Science
Languages : en
Pages : 426
Get Book Here
Book Description
This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.
Author: Johan Gabrielsson
Publisher: CRC Press
ISBN: 9789186274924
Category : Medical
Languages : en
Pages : 926
Get Book Here
Book Description
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
