Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics PDF Author: Leon Shargel
Publisher: McGraw-Hill/Appleton & Lange
ISBN: 9780838502396
Category : Biopharmaceutics
Languages : en
Pages : 625

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Book Description

Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics PDF Author: Leon Shargel
Publisher: McGraw-Hill/Appleton & Lange
ISBN: 9780838502396
Category : Biopharmaceutics
Languages : en
Pages : 625

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Book Description


Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics PDF Author: Notari
Publisher: CRC Press
ISBN: 9780824775230
Category : Science
Languages : en
Pages : 448

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Book Description
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface to the Fourth Edition -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Nomenclature -- 1: Introduction -- References -- 2: Rates, Rate Constants, and Order -- I. Order -- II. Rates and Rate Constants -- 3: Active and Passive Transport -- I. Introduction -- II. Passive Transport -- III. Active Transport -- References -- 4: Pharmacokinetics -- I. Introduction -- II. Drug Disposition -- III. Constant-Rate Intravenous Infusion -- IV. Compartmental Models and Their Limitations -- V. Absorption Rate Constants -- References -- 5: Biopharmaccutics -- I. Extravascular Administration -- II. Absorption of Drugs from the Gastrointestinal Tract -- III. Factors Influencing Bioavailability -- IV. Evaluation of the Bioavailability of a Single Drug -- V. Drug Delivery to Prolong Duration -- References -- 6: Dosage Regimens -- I. Introduction -- II. Accumulation During Repetitive Dosing -- III. Adjustment of Dosage Regimen in Renal Failure -- IV. Multiple Dosing of Constant-Rate Intravenous Infusions -- References -- 7: Pharmacokinetic Aspects of Structural Modifications in Drug Design and Therapy -- I. Introduction -- II. Antimicrobial Agents -- III. Pharmacokinetics of Prodrugs -- IV. Stereoisomers -- References -- 8: Pharmacokinetic Applications in Clinical Practice -- I. Introduction -- II. Pharmacokinetic Drug Interactions -- III. Clinical Pharmacokinetics -- References -- Appendix -- Index

Biopharmaceutics and Pharmacokinetics

Biopharmaceutics and Pharmacokinetics PDF Author: V. Venkateswarlu
Publisher: Pharmamed Press
ISBN: 9789352300532
Category : Medical
Languages : en
Pages : 530

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Book Description
This book deals with the basics of the two disciplines of biopharmaceutics and pharmacokinetics. Different factors such as biological, physiochemical and formulation that influence the therapeutic efficacy of a drug are covered in biopharmaceutics. The absorption, distribution, metabolism and excretion of drugs are studied under this subject. Salient Features - Basics of biopharmaceutics and pharmacokinetics help to understand the various procedures and advances in drug design, product development, therapeutic drug monitoring, etc. - Pharmacokinetics covers the fundamentals of one compartment open model, multi-compartmental models. One compartment open model is presented in an elaborate manner to make the students familiar with various aspects of pharmacokinetics - Mathematical equations are developed using simple integration and differentiation methods - Practice problems are provided wherever necessary, and a question bank is included at the end of each chapter - Extreme care has been exercised to present the concepts in a simple way Second Edition includes - Application of principles in formulation development in industry for successful bioequivalence studies is included - One chapter on "In-vitro Dissolution Testing" is included to evaluate test formulations to chose right product for bioequivalence studies - A chapter on biostatistics with practice problems is included

Textbook of Biopharmaceutics and Clinical Pharmacokinetics

Textbook of Biopharmaceutics and Clinical Pharmacokinetics PDF Author: Sarfaraz Niazi
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 364

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Book Description


Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics PDF Author: Panos Macheras
Publisher: Springer Science & Business Media
ISBN: 0387319107
Category : Mathematics
Languages : en
Pages : 446

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Book Description
This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics PDF Author: Milo Gibaldi
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 196

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Book Description


Biopharmaceutics & Pharmacokinetics

Biopharmaceutics & Pharmacokinetics PDF Author: Dr. A. R. Paradkar
Publisher: Pragati Books Pvt. Ltd.
ISBN: 9788185790374
Category :
Languages : en
Pages : 198

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Book Description


Biopharmaceutics Applications in Drug Development

Biopharmaceutics Applications in Drug Development PDF Author: Rajesh Krishna
Publisher: Springer Science & Business Media
ISBN: 038772379X
Category : Medical
Languages : en
Pages : 416

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Book Description
The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.

Basic Pharmacokinetics and Pharmacodynamics

Basic Pharmacokinetics and Pharmacodynamics PDF Author: Sara E. Rosenbaum
Publisher: John Wiley & Sons
ISBN: 1119143160
Category : Medical
Languages : en
Pages : 589

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Book Description
Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out ... and also for use as a reference book ...." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD .... “ (British Toxicology Society Newsletter)

Basic Pharmacokinetics and Pharmacodynamics

Basic Pharmacokinetics and Pharmacodynamics PDF Author: Sara E. Rosenbaum
Publisher: John Wiley & Sons
ISBN: 111819778X
Category : Medical
Languages : en
Pages : 440

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Book Description
With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.