The Handbook of Medicinal Chemistry PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Handbook of Medicinal Chemistry PDF full book. Access full book title The Handbook of Medicinal Chemistry by Andrew Davis. Download full books in PDF and EPUB format.
Author: Andrew Davis
Publisher: Royal Society of Chemistry
ISBN: 1782621830
Category : Science
Languages : en
Pages : 789
Get Book Here
Book Description
Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.
Author: Andrew Davis
Publisher: Royal Society of Chemistry
ISBN: 1782621830
Category : Science
Languages : en
Pages : 789
Get Book Here
Book Description
Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.
Author: John Eddowes Bowman
Publisher:
ISBN:
Category :
Languages : en
Pages : 300
Get Book Here
Book Description
Author: Camille Georges Wermuth
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 012417213X
Category : Science
Languages : en
Pages : 903
Get Book Here
Book Description
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. - Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field - Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts - Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research - An image bank is available for instructors at www.textbooks.elsevier.com
Author: Frank D. King
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 488
Get Book Here
Book Description
This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.
Author: William Houston Greene
Publisher:
ISBN:
Category : Clinical chemistry
Languages : en
Pages : 328
Get Book Here
Book Description
Author: Heinz Becker
Publisher: Elsevier
ISBN: 1483146286
Category : Science
Languages : en
Pages : 770
Get Book Here
Book Description
Organicum: Practical Handbook of Organic Chemistry focuses on the theory, laboratory practice, and aspects of technical use related to organic chemistry. This book discusses the standard apparatus for organic reactions, heating of inflammable liquids, performance of a simple distillation, and partition chromatography in separating columns. The time factor in organic chemical reactions, distribution of the electron density in organic molecules, and synthesis of ethers from alkoxides or phenoxides are also elaborated. This text likewise covers the mechanism of electrophilic aromatic substitution, quinones from aromatic hydrocarbons, and reduction of carbonyl compounds by means of complex hydrides. Other topics include the reaction with ammoniacal solution of a silver salt, preparation of the dimedone derivatives, and saturated aliphatic hydrocarbons. This publication is suitable for chemists and researchers conducting work in organic chemistry.
Author: Christoph Sotriffer
Publisher: John Wiley & Sons
ISBN: 3527633340
Category : Medical
Languages : en
Pages : 774
Get Book Here
Book Description
Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy. Alternatively, if active ligands are already available, molecular similarity searches can be used to find new molecules. This virtual screening can even be applied to compounds that have yet to be synthesized, as opposed to "real" screening that requires cost- and labor-intensive laboratory testing with previously synthesized drug compounds. Unique in its focus on the end user, this is a real "how to" book that does not presuppose prior experience in virtual screening or a background in computational chemistry. It is both a desktop reference and practical guide to virtual screening applications in drug discovery, offering a comprehensive and up-to-date overview. Clearly divided into four major sections, the first provides a detailed description of the methods required for and applied in virtual screening, while the second discusses the most important challenges in order to improve the impact and success of this technique. The third and fourth, practical parts contain practical guidelines and several case studies covering the most important scenarios for new drug discovery, accompanied by general guidelines for the entire workflow of virtual screening studies. Throughout the text, medicinal chemists from academia, as well as from large and small pharmaceutical companies report on their experience and pass on priceless practical advice on how to make best use of these powerful methods.
Author: Jayaveera K.N./ Subramanyam S. & Reddy, Yogananda K.
Publisher: S. Chand Publishing
ISBN: 8121942454
Category : Medical
Languages : en
Pages : 166
Get Book Here
Book Description
Introduction 2. Synthesis Of Some Official Medicinal Compounds 3. Assay Of Some Official Compounds 4. Monograph Analysis Of The Following Compounds 5. Identification And Estimation Of Drug Metabolites From Biological Fluids 6. Determination Of Partition Coefficient Of Compounds For Qsar Analysis 7. I.R. Spectra Of Some Official Medicinal Compounds
Author: Marc Harrold
Publisher: ASHP
ISBN: 1585283649
Category : Medical
Languages : en
Pages : 405
Get Book Here
Book Description
Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
