A Microflow Cytometer with Simultaneous Dielectrophoretic Actuation for the Optical Assay and Capacitive Cytometry of Individual Fluid Suspended Bioparticles PDF Download
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Author: Sean Forrest Romanuik
Publisher:
ISBN:
Category :
Languages : en
Pages : 362
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Book Description
Microflow -- Microfluidic -- Cytometer -- Cytometry -- Dielectrophoretic -- Dielectrophoresis -- Interferometer -- Interferometric -- Capacitive Sensor -- Capacitance Sensing -- Capacitive Detector -- Capacitance Detection -- Polystyrene -- Optical Assay -- Electrokinetic -- Actuation -- Yeast -- Saccharomyces cerevisiae -- Single-cell Diagnostic -- Single-cell Diagnosis -- Dielectric Modeling -- COMSOL -- Tracker -- Trajectory -- Velocity Profile -- Capacitive Signature -- Capacitance Signature -- Microelectrode.
Author: Sean Forrest Romanuik
Publisher:
ISBN:
Category :
Languages : en
Pages : 362
Get Book Here
Book Description
Microflow -- Microfluidic -- Cytometer -- Cytometry -- Dielectrophoretic -- Dielectrophoresis -- Interferometer -- Interferometric -- Capacitive Sensor -- Capacitance Sensing -- Capacitive Detector -- Capacitance Detection -- Polystyrene -- Optical Assay -- Electrokinetic -- Actuation -- Yeast -- Saccharomyces cerevisiae -- Single-cell Diagnostic -- Single-cell Diagnosis -- Dielectric Modeling -- COMSOL -- Tracker -- Trajectory -- Velocity Profile -- Capacitive Signature -- Capacitance Signature -- Microelectrode.
Author: Frances S. Ligler
Publisher: CRC Press
ISBN: 0429533748
Category : Science
Languages : en
Pages : 637
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Book Description
This book describes the continuing development of inexpensive, portable flow cytometers through incorporation of microfluidic technologies and small optical components. The underlying microfluidic theories essential for microflow cytometry isdiscussed in detail, as well as advances that are representative of the current state-of-the-art. Design and fabrication strategies for these innovative component technologies will be subsequently presented by numerous research groups leading the field. Integration of the components into functional prototype devices for analysis and manipulation of particles and cells are reviewed. Multiple currently available commercial systems are examined to highlight both strengths and areas for improvement.
Author: Wonhee Lee
Publisher: Springer
ISBN: 3319441396
Category : Technology & Engineering
Languages : en
Pages : 287
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Book Description
This book delves into the recent developments in the microscale and microfluidic technologies that allow manipulation at the single and cell aggregate level. Expert authors review the dominant mechanisms that manipulate and sort biological structures, making this a state-of-the-art overview of conventional cell sorting techniques, the principles of microfluidics, and of microfluidic devices. All chapters highlight the benefits and drawbacks of each technique they discuss, which include magnetic, electrical, optical, acoustic, gravity/sedimentation, inertial, deformability, and aqueous two-phase systems as the dominant mechanisms utilized by microfluidic devices to handle biological samples. Each chapter explains the physics of the mechanism at work, and reviews common geometries and devices to help readers decide the type of style of device required for various applications. This book is appropriate for graduate-level biomedical engineering and analytical chemistry students, as well as engineers and scientists working in the biotechnology industry.
Author: Yong Zeng
Publisher: MDPI
ISBN: 3039215949
Category : Technology & Engineering
Languages : en
Pages : 138
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Book Description
Bionanoparticles such as microorganisms and exosomes are recoganized as important targets for clinical applications, food safety, and environmental monitoring. Other nanoscale biological particles, includeing liposomes, micelles, and functionalized polymeric particles are widely used in nanomedicines. The recent deveopment of microfluidic and nanofluidic technologies has enabled the separation and anslysis of these species in a lab-on-a-chip platform, while there are still many challenges to address before these analytical tools can be adopted in practice. For example, the complex matrices within which these species reside in create a high background for their detection. Their small dimension and often low concentration demand creative strategies to amplify the sensing signal and enhance the detection speed. This Special Issue aims to recruit recent discoveries and developments of micro- and nanofluidic strategies for the processing and analysis of biological nanoparticles. The collection of papers will hopefully bring out more innovative ideas and fundamental insights to overcome the hurdles faced in the separation and detection of bionanoparticles.
Author:
Publisher:
ISBN: 9783038421948
Category : Single cell proteins
Languages : en
Pages : 0
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Book Description
Annotation Cells play significant roles in our day to day life. However, the interactions of cells, the cellular responses of organelles to molecules, and their intracellular behaviour, are still not fully understood. To better understand the physiological interactions among molecules, organelles, and cells, the ensemble measurement of (on average, millions of) cells cannot provide detailed information. However, for example, research concerning the differentiation behaviors of stem cells or the metastatic processes of tumour initiation requires detailed information. Understanding genomic sequence information at a single cell level can promote an understanding of how individual parts of a cell are integrated in time and space to form dynamic cellular processes. The relationship between cellular heterogeneity and signaling pathway regulation may result in an understanding of disease states that can potentially drive therapeutic interventions. Thus single cell analysis (SCA) has been emerging as a powerful method of investigating exciting new insights into genomics, fluxomics, proteomics, and systems biology.
Author: Michael P. Hughes
Publisher: Humana Press
ISBN: 9781617796401
Category : Science
Languages : en
Pages : 0
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Book Description
Microelectronic engineering has revolutionized electronics, providing new, faster and cheaper ways of doing things – and now the same technology is being applied to biotechnology and molecular biology. As sample volume is reduced, reaction speed and detector sensitivity are increased whilst sample and reagent requirements and device cost are reduced. Microelectronic engineering provides the potential for bench-top versions of large and expensive equipment such as flow cytometry, or novel ones that exploit physical phenomena on the micron scale, such as dielectrophoresis for cell analysis. In Microengineering in Biotechnology, experts in the field contribute chapters aimed at instilling in the reader a working understanding of the methods underlying microengineering and the means by which such methods can be used for a range of analytical techniques. It describes the methods by which microengineered devices can be built to perform a number of applications and considers how the field may progress by examining some more complex lab on a chip devices which have great potential in the advancement of the way in which molecular biology is performed. As a volume in the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Cutting-edge yet easy-to-use, Microengineering in Biotechnology serves as a reference guide for practical microengineering techniques and as a route into the development of new devices for biological applications in order to strengthen the promising union of molecular and cellular biology with microelectronics.
Author: Xiujun James Li
Publisher: Woodhead Publishing
ISBN: 9780857096975
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.
Author: Dongqing Li
Publisher: Elsevier
ISBN: 0080530745
Category : Science
Languages : en
Pages : 653
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Book Description
A lab-on-a-chip device is a microscale laboratory on a credit-card sized glass or plastic chip with a network of microchannels, electrodes, sensors and electronic circuits. These labs on a chip can duplicate the specialized functions as performed by their room-sized counterparts, such as clinical diagnoses, PCR and electrophoretic separation. The advantages of these labs on a chip include significant reduction in the amounts of samples and reagents, very short reaction and analysis time, high throughput and portability. Generally, a lab-on-a-chip device must perform a number of microfluidic functions: pumping, mixing, thermal cycling/incubating, dispensing, and separating. Precise manipulation of these microfluidic processes is key to the operation and performance of labs on a chip. The objective of this book is to provide a fundamental understanding of the interfacial electrokinetic phenomena in several key microfluidic processes, and to show how these phenomena can be utilised to control the microfluidic processes. For this purpose, this book emphasises the theoretical modelling and the numerical simulation of these electrokinetic phenomena in microfluidics. However, experimental studies of the electrokinetic microfluidic processes are also highlighted in sufficient detail. The first book which systematically reviews electrokinetic microfluidics processes for lab-on-a chip applications Covers modelling and numerical simulation of the electrokinetic microfluidics processes Providing information on experimental studies and details of experimental techniques, which are essential for those who are new to this field
Author: Roger Narayan
Publisher: Woodhead Publishing
ISBN: 0081000782
Category : Medical
Languages : en
Pages : 318
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Book Description
Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications Includes contributions from leading international researchers with extensive experience in developing medical biosensors Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care
Author: Hywel Morgan
Publisher: Research Studies Press Limited
ISBN: 9780863802553
Category : Colloids
Languages : en
Pages : 0
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Book Description
Biologists, physicists and engineers are working together to make ever-smaller devices capable of studying the properties of tiny biological particles. Using nano-electrodes, encapsulated in a device with dimensions of a few hundred millionths of a metre, it is now possible to manipulate and trap single nano-scale biological particles such as a virus. The precisely controlled electric fields generated within the device can be used to trap single particles in field-cages or separate different viruses from each other, for example. This book is an introduction to the science behind the new technology, and explains how the electric field interacts with the particles. It describes how these micro-systems are manufactured and how they are used to study the electrical properties of the particles.
