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Author: Kathrin Herrmann
Publisher:
ISBN: 9789004356184
Category : Animal experimentation
Languages : en
Pages : 0
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Book Description
Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.
Author: Kathrin Herrmann
Publisher:
ISBN: 9789004356184
Category : Animal experimentation
Languages : en
Pages : 0
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Book Description
Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.
Author: R E Hester
Publisher: Royal Society of Chemistry
ISBN: 1847552455
Category : Science
Languages : en
Pages : 137
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Book Description
Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to the validation of alternative tests, in vitro testing for endocrine disruptors, intelligent approaches to safety evaluation of chemicals, alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetic industries.
Author:
Publisher:
ISBN:
Category : Alternative toxicity testing
Languages : en
Pages : 56
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Book Description
Author: William Moy Stratton Russell
Publisher: Hyperion Books
ISBN:
Category : Nature
Languages : en
Pages : 256
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128136987
Category : Medical
Languages : en
Pages : 384
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Book Description
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Author: National Institutes of Health (U.S.). Office for Protection from Research Risks
Publisher:
ISBN:
Category : Animal experimentation
Languages : en
Pages : 40
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Book Description
Author: F. Barbara Orlans
Publisher: Oxford University Press
ISBN: 0199762805
Category : Medical
Languages : en
Pages : 312
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Book Description
Few arguments in biomedical experimentation have stirred such heated debate in recent years as those raised by animal research. In this comprehensive analysis of the social, political, and ethical conflicts surrounding the use of animals in scientific experiments, Barbara Orlans judges both ends of the spectrum in this debate -- unconditional approval or rejection of animal experimentation -- to be untenable. Instead of arguing for either view, she thoughtfully explores the ground between the extremes, and convincingly makes the case for public policy reforms that serve to improve the welfare of laboratory animals without jeopardizing scientific endeavor. This book presents controversial issues in a balanced manner based on careful historical analysis and original research. Different mechanisms of oversight for animal experiments are compared and those that have worked well are identified. This compelling work will be of interest to biomedical scientists, ethicists, animal welfare advocates and other readers concerned with this critical issue.
Author: Ingrid Newkirk
Publisher: Simon & Schuster
ISBN: 1501198556
Category : Nature
Languages : en
Pages : 304
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Book Description
The founder and president of PETA, Ingrid Newkirk, and bestselling author Gene Stone explore the wonders of animal life with “admiration and empathy” (The New York Times Book Review) and offer tools for living more kindly toward them. In the last few decades, a wealth of new information has emerged about who animals are: astounding beings with intelligence, emotions, intricate communications networks, and myriad abilities. In Animalkind, Ingrid Newkirk and Gene Stone present these findings in a concise and awe-inspiring way, detailing a range of surprising discoveries, like that geese fall in love and stay with a partner for life, that fish “sing” underwater, and that elephants use their trunks to send subsonic signals, alerting other herds to danger miles away. Newkirk and Stone pair their tour through the astounding lives of animals with a guide to the exciting new tools that allow humans to avoid using or abusing animals as we once did. Whether it’s medicine, product testing, entertainment, clothing, or food, there are now better options to all the uses animals once served in human life. We can substitute warmer, lighter faux fleece for wool, choose vegan versions of everything from shrimp to marshmallows, reap the benefits of animal-free medical research, and scrap captive orca exhibits and elephant rides for virtual reality and animatronics. Animalkind provides a fascinating look at why our fellow living beings deserve our respect, and lays out the steps everyone can take to put this new understanding into action.
Author: L. F. M. van Zutphen
Publisher: Elsevier Science Health Science Division
ISBN: 9780444506122
Category : Medical
Languages : en
Pages : 416
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Book Description
The welfare of laboratory animals, as well as the ethical issues involved in the humane use of animals for scientific purposes, are discussed in this new revised edition. Information is included on the biology and husbandry of animal models; on behavior, stress and well-being; genetic and microbiological standardization; health monitoring; anaesthesiology; animal alternatives; ethics. This book addresses all of the aspects that scientists need to know when considering the design of an animal experiment. Replacement, reduction and refinement of animal experiments are the guiding principles for its contents.
Author: Jack Botting
Publisher: Open Book Publishers
ISBN: 1783741171
Category : Medical
Languages : en
Pages : 246
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Book Description
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
