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Author: Michel Morange
Publisher: Harvard University Press
ISBN: 9780674001695
Category : History
Languages : en
Pages : 350
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Book Description
Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.
Author: Michel Morange
Publisher: Harvard University Press
ISBN: 9780674001695
Category : History
Languages : en
Pages : 350
Get Book Here
Book Description
Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.
Author: Michel Morange
Publisher: Harvard University Press
ISBN: 0674281365
Category : Science
Languages : en
Pages : 529
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Book Description
In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics. Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution.
Author: William C. Summers
Publisher: Yale University Press
ISBN: 9780300174250
Category : Biography & Autobiography
Languages : en
Pages : 272
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Book Description
A self-taught scientist determined to bring science out of the laboratory and into the practical arena, French-Canadian Felix d’Herelle (1873-1949) made history in two different fields of biology. Not only was he first to demonstrate the use and application of bacteria for biological control of insect pests, he also became a seminal figure in the history of molecular biology. This engaging book is the first full biography of d’Herelle, a complex figure who emulated Louis Pasteur and influenced the course of twentieth-century biology, yet remained a controversial outsider to the scientific community. Drawing on family papers, archival sources, interviews, and d’Herelle’s published and unpublished writings, Dr. William C. Summers tells the fascinating story of the scientist’s life and the work that took him around the globe. In 1917, d’Herelle published the first paper describing the phenomenon of the bacteriophage and its biological nature. A series of more than 110 articles and 6 major books followed, in which d’Herelle established the foundation for the later work of the Phage Group in molecular biology. Yet d’Herelle sometimes inspired animosity in others--he was drummed out of the Pasteur Institute, he held only one brief permanent position in the scientific establishment (at Yale University from 1928 to 1933), and he was bewildered by the social nuances of the world of international science. His story is more than the biography of a single brilliant scientist; it is also a fascinating chapter in the history of biology.
Author: John Cairns
Publisher: CSHL Press
ISBN: 0879698004
Category : Bactériophages
Languages : en
Pages : 399
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Book Description
First published in 1966 as a 60th birthday tribute to Max Delbrck, this influential work is republished as "The Centennial Edition." The book was hailed as "[introducing] into the literature of science, for the first time, a self-conscious historical element in which the participants in scientific discovery engage in writing their own chronicle ("Journal of History of Biology").
Author: Michael Fry
Publisher: Academic Press
ISBN: 012802108X
Category : Science
Languages : en
Pages : 572
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Book Description
Landmark Experiments in Molecular Biology critically considers breakthrough experiments that have constituted major turning points in the birth and evolution of molecular biology. These experiments laid the foundations to molecular biology by uncovering the major players in the machinery of inheritance and biological information handling such as DNA, RNA, ribosomes, and proteins. Landmark Experiments in Molecular Biology combines an historical survey of the development of ideas, theories, and profiles of leading scientists with detailed scientific and technical analysis. - Includes detailed analysis of classically designed and executed experiments - Incorporates technical and scientific analysis along with historical background for a robust understanding of molecular biology discoveries - Provides critical analysis of the history of molecular biology to inform the future of scientific discovery - Examines the machinery of inheritance and biological information handling
Author: Harrison G. Echols
Publisher: Univ of California Press
ISBN: 0520403061
Category :
Languages : en
Pages : 488
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Book Description
Author: Alfred Henry Sturtevant
Publisher: CSHL Press
ISBN: 9780879696078
Category : Medical
Languages : en
Pages : 190
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Book Description
In the small “Fly Room†at Columbia University, T.H. Morgan and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller, carried out the work that laid the foundations of modern, chromosomal genetics. The excitement of those times, when the whole field of genetics was being created, is captured in this book, written in 1965 by one of those present at the beginning. His account is one of the few authoritative, analytic works on the early history of genetics. This attractive reprint is accompanied by a website, http://www.esp.org/books/sturt/history/ offering full-text versions of the key papers discussed in the book, including the world's first genetic map.
Author: Kensal Van Holde
Publisher: Academic Press
ISBN: 0128129182
Category : Science
Languages : en
Pages : 244
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Book Description
The Evolution of Molecular Biology: The Search for the Secrets of Life provides the historical knowledge behind techniques founded in molecular biology, also presenting an appreciation of how, and by whom, these discoveries were made. It deals with the evolution of intellectual concepts in the context of active research in an approachable language that accommodates readers from a variety of backgrounds. Each chapter contains a prologue and epilogue to create continuity and provide a complete framework of molecular biology. This foundational work also functions as a historical and conceptual supplement to many related courses in biochemistry, biology, chemistry, genetics and history of science. In addition, the book demonstrates how the roots of discovery and advances–and an individual's own research–have grown out of the history of the field, presenting a more complete understanding and context for scientific discovery. - Expands on the development of molecular biology from the convergence of two independent disciplines, biochemistry and genetics - Discusses the value of molecular biology in a variety of applications - Includes research ethics and the societal implications of research - Emphasizes the human aspects of research and the consequences of such advances to society
Author: Alfred Day Hershey
Publisher: CSHL Press
ISBN: 9780879695675
Category : Biography & Autobiography
Languages : en
Pages : 396
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Book Description
An absorbing portrait of the pioneering molecular biologist best known for demonstrating that DNA is the genetic component of phages, through essays and reminiscences from twenty–three distinguished scientists whose work and careers were influenced by the man and his science.
Author: J. C. Avise
Publisher: Springer Science & Business Media
ISBN: 1461523818
Category : Science
Languages : en
Pages : 522
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Book Description
Molecular approaches have opened new windows on a host of ecological and evolutionary disciplines, ranging from population genetics and behavioral ecology to conservation biology and systematics. Molecular Markers, Natural History and Evolution summarizes the multi-faceted discoveries about organisms in nature that have stemmed from analyses of genetic markers provided by polymorphic proteins and DNAs. The first part of the book introduces rationales for the use of molecular markers, provides a history of molecular phylogenetics, and describes a wide variety of laboratory methods and interpretative tools in the field. The second and major portion of the book provides a cornucopia of biological applications for molecular markers, organized along a scale from micro-evolutionary topics (such as forensics, parentage, kinship, population structure, and intra-specific phylogeny) to macro-evolutionary themes (including species relationships and the deeper phylogenetic structure in the tree of life). Unlike most prior books in molecular evolution, the focus is on organismal natural history and evolution, with the macromolecules being the means rather than the ends of scientific inquiry. Written as an intellectual stimulus for the advanced undergraduate, graduate student, or the practicing biologist desiring a wellspring of research ideas at the interface of molecular and organismal biology, this book presents material in a manner that is both technically straightforward, yet rich with concepts and with empirical examples from the world of nature.
