A Handbook of Derivatives for Mass Spectrometry PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download A Handbook of Derivatives for Mass Spectrometry PDF full book. Access full book title A Handbook of Derivatives for Mass Spectrometry by Vladimir Zaikin. Download full books in PDF and EPUB format.
Author: Vladimir Zaikin
Publisher: IM Publications
ISBN: 1901019098
Category : Derivatization
Languages : en
Pages : 545
Get Book Here
Book Description
Chemical derivatisation of functional groups has proved popular since the beginning of organic mass spectrometry as a means to enhance the stability and volatility of the analytes as well as facilitating structure elucidation. This book provides comprehensive information on the wide range of derivatisation methods. Each chapter looks at a particular area of derivatisation and includes extensive references to the literature for further research where necessary. There are nearly 1800 references, which, as well as full bibliographic information, include chapter/paper titles where appropriate and Digital Object Identifiers (DOIs) to allow easy retrieval of the online version of the referenced publication. The emergence of atmospheric pressure ionisation and other soft ionisation techniques has not diminished the interest in such chemical techniques, as witnessed by the many chemical tags used in quantitative proteomics (Chapter 9). The last two chapters, a substantial part of the book, deal with derivatisation for use with soft ionisation of both small and large molecules. Chapters Silylation Acylation Alkylation (Arylation) Cyclic derivatives Monofunctional compounds Polyfunctional compounds On-line derivatisation/degradation Soft ionisation—small molecules Soft ionisation—large molecules
Author: Vladimir Zaikin
Publisher: IM Publications
ISBN: 1901019098
Category : Derivatization
Languages : en
Pages : 545
Get Book Here
Book Description
Chemical derivatisation of functional groups has proved popular since the beginning of organic mass spectrometry as a means to enhance the stability and volatility of the analytes as well as facilitating structure elucidation. This book provides comprehensive information on the wide range of derivatisation methods. Each chapter looks at a particular area of derivatisation and includes extensive references to the literature for further research where necessary. There are nearly 1800 references, which, as well as full bibliographic information, include chapter/paper titles where appropriate and Digital Object Identifiers (DOIs) to allow easy retrieval of the online version of the referenced publication. The emergence of atmospheric pressure ionisation and other soft ionisation techniques has not diminished the interest in such chemical techniques, as witnessed by the many chemical tags used in quantitative proteomics (Chapter 9). The last two chapters, a substantial part of the book, deal with derivatisation for use with soft ionisation of both small and large molecules. Chapters Silylation Acylation Alkylation (Arylation) Cyclic derivatives Monofunctional compounds Polyfunctional compounds On-line derivatisation/degradation Soft ionisation—small molecules Soft ionisation—large molecules
Author: Karl Blau
Publisher: John Wiley & Sons
ISBN:
Category : Science
Languages : en
Pages : 406
Get Book Here
Book Description
A practical handbook of derivatives and an invaluable reference source for chemists using chromatography for derivatization. Since publication of the first edition in 1977, there have been many developments in chemical derivatization which have gone hand-in-hand with advances in chromatography. This handbook will be of use not only in core chemistry but also in food analysis, clinical and biochemical analysis, toxicological, environmental and forensic testing and refining.
Author: Daniel R. Knapp
Publisher: John Wiley & Sons
ISBN: 9780471034698
Category : Science
Languages : en
Pages : 772
Get Book Here
Book Description
Brings together practical information previously available only innumerous separate sources. Handbook of Analytical DerivationReactions begins with an overview of analytical derivatizationwith a section on apparatus. Describes analytical derivatizationmethods organized according to the sample to be derivatized.Discussion of methods includes derivative type, reagent, sampletype, reaction, and typical procedure with comments and referencesfor each.
Author: Hans-Joachim Hubschmann
Publisher: John Wiley & Sons
ISBN: 3527334742
Category : Science
Languages : en
Pages : 884
Get Book Here
Book Description
The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.
Author: Wenkui Li
Publisher: John Wiley & Sons
ISBN: 111867135X
Category : Science
Languages : en
Pages : 709
Get Book Here
Book Description
Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.
Author: R. W. Frei
Publisher: Springer
ISBN:
Category : Science
Languages : en
Pages : 368
Get Book Here
Book Description
The first volume in this series is devoted to derivatization techniques in chromatography, for very obvious reasons. In gas chromatography (GC) chemical derivatization as an aid to expand the usefulness of the technique has been known for more than a decade and has become an established approach. The first chapter deals to a great extent with derivatization for the purpose of making compounds amenable to Gc. Although the discussion concentrates on pesticides, some generally valid conclusions can be drawn from this chapter. Chemistry will not be limited to the separation-it can also have a pronounced impact on the sample cleanup, another topic cov ered in Chapter 1. Since the introduction of coupled GC-mass spectroscopy (GC-MS), a very powerful tool, derivatization techniques have taken still another di rection-taking into consideration chromatographic as well as mass spec trometric improvement of the compounds of interest. Cyclic boronates are discussed as derivatization reagents for this purpose in the second chapter.
Author: William J. Griffiths
Publisher: Royal Society of Chemistry
ISBN: 0854042997
Category : Medical
Languages : en
Pages : 336
Get Book Here
Book Description
In this comprehensive resource the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology.
Author: Peter Kusch
Publisher: BoD – Books on Demand
ISBN: 1838818650
Category : Science
Languages : en
Pages : 144
Get Book Here
Book Description
Gas chromatography (GC) is one of the most important types of chromatography used in analytical chemistry for separating and analyzing chemical organic compounds. Today, gas chromatography is one of the most widespread investigation methods of instrumental analysis. This technique is used in the laboratories of chemical, petrochemical, and pharmaceutical industries, in research institutes, and also in clinical, environmental, and food and beverage analysis. This book is the outcome of contributions by experts in the field of gas chromatography and includes a short history of gas chromatography, an overview of derivatization methods and sample preparation techniques, a comprehensive study on pyrazole mass spectrometric fragmentation, and a GC/MS/MS method for the determination and quantification of pesticide residues in grape samples.
Author: Jürgen H Gross
Publisher: Springer Science & Business Media
ISBN: 3642107095
Category : Science
Languages : en
Pages : 773
Get Book Here
Book Description
This book offers a balanced mixture of practice-oriented information and theoretical background as well as numerous references, clear illustrations, and useful data tables. Problems and solutions are accessible via a special website. This new edition has been completely revised and extended; it now includes three new chapters on tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry.
Author: Alex. G. Harrison
Publisher: Taylor & Francis
ISBN: 1351461540
Category : Science
Languages : en
Pages : 221
Get Book Here
Book Description
The only comprehensive guide to CIMS applications in structural elucidation and analytical studies Chemical Ionization Mass Spectrometry, 2nd Edition, provides a comprehensive, up-to-date review of CIMS applications in structural elucidation and quantitative analytical studies. For the benefit of readers without a background in gaseous ion chemistry, a thorough review is presented in Chapter 2. Other chapters discuss such topics as reagent ion systems within the context of the thermochemistry and kinetics of the ionization process, including reactions and the type of information obtained; isotopic exchange reactions; stereochemical effects in chemical ionization; and reactive ion/molecule collisions in quadrupole cells. Chemical ionization mass spectra of 13 classes of compounds are discussed in detail to illustrate the influence of different functional groups on the spectra observed. Chemical Ionization Mass Spectrometry, 2nd Edition will be a valuable reference for anyone interested in mass spectrometry and gaseous ion chemistry in general.
