A Developmental Study of Lethal Factors in Drosophila Melanogaster PDF Download
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Author: Frank Seto
Publisher:
ISBN:
Category :
Languages : en
Pages : 230
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Author: Frank Seto
Publisher:
ISBN:
Category :
Languages : en
Pages : 230
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Book Description
Author: Phillip Jennings Reitan
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 302
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Author: Corina Schütt
Publisher:
ISBN:
Category :
Languages : de
Pages : 60
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Author: Jyothi R. P.
Publisher:
ISBN:
Category :
Languages : en
Pages : 30
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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
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Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: Robert McClam Welch
Publisher:
ISBN:
Category : Variation (Biology)
Languages : en
Pages : 262
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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The merits of utilising the Drosophila melanogaster embryo for the genetic analysis of cellular differentiation are discussed. The advantages are seen to lie in the ease of isolation and manipulation of lethal mutations, and the possibility that mutants of specific developmental processes can be selected. A major disadvantage of the Drosophila embryo is considered to be the problem of discovering whether a lethal mutant directly affects a particular cell type or not; in the whole embryo, the specific effects of a lethal factor may often be confused with their developmental ramifications. It is proposed that in vitro culture might provide a straightforward method of assessing the effects of a lethal mutation on individual cell types.In vitro cultures were made from dispersed cells of gastrula-stage lethal embryos. In the early part of the work a number of temperature-sensitive embryonic lethals were isolated and one of them was cultured by a technique utilising bulk quantities of embryos. The major conclusion from this work was that especially careful attention would have to be paid to genetic background when culturing lethal mutants in vitro. Following this, a technique for the production of high quality cultures from single embryos was developed. Whereas a previously- reported technique had been claimed to give the differentiation of nerve and rnusclo cells, the new technique gavexiiithe differentiation of five identified larval cell types, and, furthermore, the cultueres could continue to develop for several weeks. This new technique of culturing sing le embryos was applied to a number of embryonic lethals, both unconditional and temperature-sensitive.The results of culturing experiments were consist ent with, and extended, those from earlier studies of the lethal mutants which had utilised other techniques (examination of live embryos and stained sections; in vivo culture). Whilst the results show that in vitro culture limits the possibility of deleterious interaction between different cell types, and therefore renders the identific ation of specific genetic effects more straightforward, they provide strong circumstantial evidence that some interactions do take place in vitro. The consequences of such interactions are discussed, and means for the assessment of their importance in the development of cultures of mutant cells are suggested. It is pointed out that it may be possible to use in vitro culture systems to experimentally analyse mutants of known cellular interactions.
Author: Helen Sink
Publisher: Springer Science & Business Media
ISBN: 9780387300535
Category : Science
Languages : en
Pages : 224
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Book Description
The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
Author: Katherine Armstrong
Publisher:
ISBN:
Category :
Languages : en
Pages : 148
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Book Description
Author:
Publisher: Academic Press
ISBN: 0124095984
Category : Science
Languages : en
Pages : 414
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Book Description
Apoptosis and Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis and development, and includes sections on such topics as the non-lethal role of apoptotic proteins and germ line cell death in Drosophila. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Includes descriptions of the most recent advances in the field - Covers research methods in apoptosis and development, and includes sections on such topics as the non-lethal role of apoptotic proteins and germ line cell death in Drosophila
