A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19 PDF Download
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Author: Abdelkrim Hmadcha
Publisher: Frontiers Media SA
ISBN: 2889742253
Category : Science
Languages : en
Pages : 129
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Book Description
Author: Abdelkrim Hmadcha
Publisher: Frontiers Media SA
ISBN: 2889742253
Category : Science
Languages : en
Pages : 129
Get Book Here
Book Description
Author: Lucas G. Chase
Publisher: Springer Science & Business Media
ISBN: 1627032002
Category : Science
Languages : en
Pages : 458
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Book Description
Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
Author: Richard K. Burt
Publisher: CRC Press
ISBN: 1351364766
Category : Medical
Languages : en
Pages : 687
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Book Description
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
Author: Yaoliang Tang
Publisher: Academic Press
ISBN: 0128004975
Category : Science
Languages : en
Pages : 287
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Book Description
Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Author: World Health Organization
Publisher:
ISBN: 9789241549837
Category : Medical
Languages : en
Pages : 0
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Book Description
"Infectious disease outbreaks are frequently characterized by scientific uncertainty, social and institutional disruption, and an overall climate of fear and distrust. Policy makers and public health professionals may be forced to weigh and prioritize potentially competing ethical values in the face of severe time and resource constraints. This document seeks to assist policy-makers, health care providers, researchers, and others prepare for outbreak situations by anticipating and preparing for the critical ethical issues likely to arise."--Publisher.
Author: John Rasko
Publisher: HarperCollins Australia
ISBN: 1460711467
Category : Medical
Languages : en
Pages : 285
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Book Description
The dazzling promise of stem cell medicine: does it work and will it save us? Two experts look at the hype For decades, we've been anticipating the dawn of regenerative medicine. Again and again, we've been promised that stem cells will soon cure just about every ill imaginable. If not tomorrow, then the next day, or the day after that, and so on. We're still waiting. This book is an antidote to hype and a salve to soothe the itch for stem-cell salvation. In it, Professor John Rasko, a leading physician-scientist, and writer-historian Carl Power take us on a wild historical tour of this scandal-prone field. They expose all the dirty little secrets that the hype merchants prefer to ignore - the blunders and setbacks, confusions and delusions, tricks and lies. You'll meet Alexis Carrel, who discovered how to cultivate cells in a test tube: celebrity surgeon, scientific genius and suspected Nazi sympathiser, he opened the field of modern cell science with an experiment so bogus it blocked the way forward for the next 50 years. You'll meet Don Thomas, who developed bone marrow transplantation - the first successful stem-cell therapy - but only after a miserable decade in which most of his patients died. Alongside true stem-cell pioneers, you'll meet charlatans who cooked their data and claimed fake cures - sometimes with fatal consequences. Is there any good news? Which of the many promises of stem-cell research have been kept? And what of the future? Rasko and Power insist that we can only know where we're going if we have a sense of where we've been. Their study tears down the hype surrounding stem cells in order to reveal what's still worth hoping for. PRAISE 'If you love some scandal with your science - or some science with your scandal - this is THE book for you. Brilliant stuff' Adam Spencer, University of Sydney 'Science, skulduggery and snake oil salesmen ... it is a revolution in medicine but who knew the story of stem cell science was such a ripping yarn!' Fran Kelly, ABC Radio National Breakfast 'Science isn't magic: it's a human enterprise. This enthralling book tells of high achievement and astonishing blunders in a vital field of research' Robyn Williams, science journalist and broadcaster 'A masterpiece in myth-busting which helps separate fact from fiction in the world of regenerative medicine. It shines a light on some episodes in medical history many would rather forget but also shows a way forward for stem cell research breakthroughs grounded in solid science' Sophie Scott, national medical reporter, ABC 'The stem cell revolution: myths, mistakes but mighty medical masterpiece' Sir Gustav Nossal, AC CBE FRS FAA, Australian of the Year 2000 'A compelling (and compulsory) read for anyone entranced by the latest media-promoted breakthroughs in medical research, or planning translation of new biomedical research into clinical practice' Ian Frazer, AC, FRCPE, FRCPA, FAA, FTSE Australian of the Year 2006, Australian Living Treasure 2012 'Is it really stem cells' turn to revolutionise health care? When you come across a train wreck, keep reading! You'll discover that stem cells reveal medicine in its most provocative and challenging light' Antony Basten AO FAA FTSE 'Flesh Made New is a revelation for the general reader about what lies beneath the surface of exciting scientific advances ... The book shows the value of patience and trust in robust evidence-based scientific research, and where things go off the rail, for whistleblowers and experts like the authors of this book' Lucy Turnbull AO, businesswoman, urbanist and philanthropist
Author: Subramani Mani
Publisher: Elsevier Health Sciences
ISBN: 0323875408
Category : Medical
Languages : en
Pages : 403
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Book Description
Written by physicians and scientists with expertise in this evolving area, Textbook of SARS-CoV-2 and COVID-19 provides a coherent, readable, and clinically relevant review of the biology, epidemiology, pathophysiology, immunology, clinical features, current treatment, and prevention strategies for the SARS-CoV-2 virus. Using both a systemic and topic-based approach, it summarizes and clarifies the extensive literature published on SARS-CoV-2 and COVID-19, includes a comprehensive bibliography, and provides answers to clinical questions at the point of care from multiple specialty perspectives. - Includes dedicated chapters for pulmonary, cardiac, neurological, and oral manifestations of COVID-19. - Covers therapeutics and novel therapeutic targets of SARS-CoV-2 and COVID-19. - Addresses the diagnostic and management challenges of COVID-19 in the emergency department. - Discusses COVID-19 in special populations, including the effect of SARS-CoV-2 infection in pregnant mothers and to the fetus and newborn. - Provides a systematic overview and comparison of vaccines that are approved and in development.
Author: Margaret Keatings
Publisher: Elsevier Health Sciences
ISBN: 0323873022
Category : Medical
Languages : en
Pages : 442
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Book Description
- UPDATED! Thoroughly revised and expanded coverage of top-of-mind ethical and legal topics concerning vulnerable populations; Indigenous (Joyce Echaquan Inquiry), refugees, and LGBTQ2 persons; advancing technologies and telemedicine; evolving scopes of practice of various categories of nurses; Medical Assistance in Dying (MAiD); and much more. - NEW! Coverage of Indigenous legal and ethical perspectives and ways of knowing and understanding related to health, health care, and decision making. - NEW! Up-to-date information on legal and ethical challenges in the time of SARS-CoV-2. - NEW! Case studies for the Next-Generation NCLEX® on the companion Evolve website.
Author: Paul Knoepfler
Publisher: World Scientific
ISBN: 9814508829
Category : Science
Languages : en
Pages : 368
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Book Description
Stem Cells: An Insider's Guide is an exciting new book that takes readers inside the world of stem cells guided by international stem cell expert, Dr. Paul Knoepfler. Stem cells are catalyzing a revolution in medicine. The book also tackles the exciting and hotly debated area of stem cell treatments that are capturing the public's imagination. In the future they may also transform how we age and reproduce. However, there are serious risks and ethical challenges, too. The author's goal with this insider's guide is to give readers the information needed to distinguish between the ubiquitous hype and legitimate hope found throughout the stem cell world. The book answers the most common questions that people have about stem cells. Can stem cells help my family with a serious medical problem such as Alzheimer's, Multiple Sclerosis, or Autism? Are such treatments safe? Can stem cells make me look younger or even literally stay physically young? These questions and many more are answered here.A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309170427
Category : Science
Languages : en
Pages : 112
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Book Description
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
