Author: Kadharbatcha S. Saleem
Publisher: Academic Press
ISBN: 0123850878
Category : Medical
Languages : en
Pages : 402
Book Description
A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, Second Edition maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This edition of the atlas is unlike anything else available as it includes the detailed cyto- and chemoarchitectonic delineations of the brain areas in all three planes of sections (horizontal, coronal, and sagittal) that are derived from the same animal. This is a significant progress because in functional imaging studies, such as fMRI, both the horizontal and sagittal planes of sections are often the preferred planes given that multiple functionally active regions can be visualized simultaneously in a single horizontal or sagittal section. This combined MRI and histology atlas is designed to provide an easy-to-use reference for anatomical and physiological studies in macaque monkeys, and in functional-imaging studies in human and non-human primates using fMRI and PET. The first rhesus monkey brain atlas with horizontal, coronal, and sagittal planes of sections, derived from the same animal Shows the first detailed delineations of the cortical and subcortical areas in horizontal, coronal, and sagittal plane of sections in the same animal using different staining methods Horizonal series illustrates the dorsoventral extent of the left hemisphere in 47 horizontal MRI and photomicrographic sections matched with 47 detailed diagrams (Chapter 3) Coronal series presents the full rostrocaudal extent of the right hemisphere in 76 coronal MRI and photomicrographic sections, with 76 corresponding drawings (Chapter 4) Sagittal series shows the complete mediolateral extent of the left hemisphere in 30 sagittal MRI sections, with 30 corresponding drawings (Chapter 5). The sagittal series also illustrates the location of different fiber tracts in the white matter Individual variability - provides selected cortical and subcortical areas in three-dimensional MRI (horizontal, coronal, and sagittal MRI planes). For comparison, it also provides similar areas in coronal MRI section in six other monkeys. (Chapter 6) Vasculature - indicates the corresponding location of all major blood vessels in horizontal, coronal, and sagittal series of sections Provides updated information on the cortical and subcortical areas, such as architectonic areas and nomenclature, with references, in chapter 2 Provides the sterotaxic grid derived from the in-vivo MR image
A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates
A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates
Author: Kadharbatcha S. Saleem
Publisher: Elsevier
ISBN: 0080467776
Category : Medical
Languages : en
Pages : 337
Book Description
This atlas maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This book presents the detailed mapping of the architectonic areas in the horizontal plane of sections with reference to the MRI that has not been reported previously in macaque monkeys. In the second part of the atlas, the coronal plane is presented using the same technique. A third part shows the quick identification of several important cortical and subcortical areas (around 30 areas) in horizontal, coronal and sagittal MR images. This atlas is unlike anything else available as it includes and compares each section to imaging data. This is a significant progress, as the vast majority of research in the field now routinely work with fMRI images.· Provides the first combined MRI and Histology maps of the cortical and subcortical areas of any non-human primate species· Shows the first detailed delineations of the cortical and subcortical areas in both horizontal and coronal planes in the same animal using five different staining methods· Illustrates the entire dorsoventral extent of the left hemisphere in 47 horizontal MRI and photomicrographs matched with 47 detailed diagrams (Chapter 3) · Presents the full rostrocaudal extent of the right hemisphere in 76 coronal MRI and photomicrographs, and 76 corresponding drawings (Chapter 4)· Illustrates the selected cortical and subcortical areas in horizontal, coronal and sagittal MRI planes (Chapter 5)· Provides the sterotaxic grid derived from the in-vivo MR image· Likely to become a standard reference for anatomical, physiological, and functional imaging studies in primates (fMRI, PET and MEG)
Publisher: Elsevier
ISBN: 0080467776
Category : Medical
Languages : en
Pages : 337
Book Description
This atlas maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This book presents the detailed mapping of the architectonic areas in the horizontal plane of sections with reference to the MRI that has not been reported previously in macaque monkeys. In the second part of the atlas, the coronal plane is presented using the same technique. A third part shows the quick identification of several important cortical and subcortical areas (around 30 areas) in horizontal, coronal and sagittal MR images. This atlas is unlike anything else available as it includes and compares each section to imaging data. This is a significant progress, as the vast majority of research in the field now routinely work with fMRI images.· Provides the first combined MRI and Histology maps of the cortical and subcortical areas of any non-human primate species· Shows the first detailed delineations of the cortical and subcortical areas in both horizontal and coronal planes in the same animal using five different staining methods· Illustrates the entire dorsoventral extent of the left hemisphere in 47 horizontal MRI and photomicrographs matched with 47 detailed diagrams (Chapter 3) · Presents the full rostrocaudal extent of the right hemisphere in 76 coronal MRI and photomicrographs, and 76 corresponding drawings (Chapter 4)· Illustrates the selected cortical and subcortical areas in horizontal, coronal and sagittal MRI planes (Chapter 5)· Provides the sterotaxic grid derived from the in-vivo MR image· Likely to become a standard reference for anatomical, physiological, and functional imaging studies in primates (fMRI, PET and MEG)
The Rhesus Monkey Brain in Stereotaxic Coordinates
Author: George Paxinos
Publisher: Academic Press
ISBN: 0128158530
Category : Medical
Languages : en
Pages : 394
Book Description
The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain. The fourth edition of this classic book is a complete revision featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will continue to be the indispensable resource for all scientists working on the primate nervous system. - 141 completely revised coronal diagrams and accompanying colour photographic plates spaced at approximately 120 μm intervals - 60 colour photographic coronal plates of SMI immunoreactivity with completely revised delineations - Includes MR images at approximately the same levels as the coronal diagrams - Follows the same nomenclature and abbreviations as the mouse, rat, chicken, marmoset and human brain atlases, with indications of correspondence to alternative macaque nomenclatures - This atlas was used for the delineation and nomenclature of MRI-based macaque brain atlases for neuroimaging analyses, including the SARM
Publisher: Academic Press
ISBN: 0128158530
Category : Medical
Languages : en
Pages : 394
Book Description
The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain. The fourth edition of this classic book is a complete revision featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will continue to be the indispensable resource for all scientists working on the primate nervous system. - 141 completely revised coronal diagrams and accompanying colour photographic plates spaced at approximately 120 μm intervals - 60 colour photographic coronal plates of SMI immunoreactivity with completely revised delineations - Includes MR images at approximately the same levels as the coronal diagrams - Follows the same nomenclature and abbreviations as the mouse, rat, chicken, marmoset and human brain atlases, with indications of correspondence to alternative macaque nomenclatures - This atlas was used for the delineation and nomenclature of MRI-based macaque brain atlases for neuroimaging analyses, including the SARM
Atlas of Regional Anatomy of the Brain Using MRI
Author: Jean C. Tamraz
Publisher: Springer Science & Business Media
ISBN: 3540306722
Category : Medical
Languages : en
Pages : 344
Book Description
A unique review of the essential topographical anatomy of the brain from an MRI perspective, correlating high-quality anatomical plates with high-resolution MRI images. The book includes a historical review of brain mapping and an analysis of the essential reference planes used. It provides a detailed review of the sulcal and the gyral anatomy of the human cortex, guiding readers through an interpretation of the individual brain atlas provided by high-resolution MRI. The relationship between brain structure and function is approached in a topographical fashion with an analysis of the necessary imaging methodology and displayed anatomy. An extensive coronal atlas rounds off the book.
Publisher: Springer Science & Business Media
ISBN: 3540306722
Category : Medical
Languages : en
Pages : 344
Book Description
A unique review of the essential topographical anatomy of the brain from an MRI perspective, correlating high-quality anatomical plates with high-resolution MRI images. The book includes a historical review of brain mapping and an analysis of the essential reference planes used. It provides a detailed review of the sulcal and the gyral anatomy of the human cortex, guiding readers through an interpretation of the individual brain atlas provided by high-resolution MRI. The relationship between brain structure and function is approached in a topographical fashion with an analysis of the necessary imaging methodology and displayed anatomy. An extensive coronal atlas rounds off the book.
The Marmoset Brain in Stereotaxic Coordinates
Author: George Paxinos
Publisher: Academic Press
ISBN: 9780124158184
Category : Science
Languages : en
Pages : 0
Book Description
The Marmoset Brain in Stereotaxic Coordinates is the most comprehensive atlas of the brain of this animal available. The atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most-cited book in neuroscience. It represents a collaboration between world leaders in neuroanatomy of the primate cortex and subcortex. It will be an indispensible tool for neuroanatomists, behavioral neuroscientists, and molecular biologists trying to understand the primate brain. ENDORSED BY SOCIETY FOR BRAIN MAPPING AND THERAPEUTICS (SBMT) - SBMT is a non-profit society organized for the purpose of encouraging basic and clinical scientists who are interested in areas of Brain Mapping, engineering, stem cell, nanotechnology, imaging and medical device to improve the diagnosis, treatment and rehabilitation of patients afflicted with neurological disorders. This society promotes the public welfare and improves patient care through the translation of new technologies/therapies into life saving diagnostic and therapeutic procedures. The Society is focused in breaking boundaries of science, technology, medicine, art and healthcare policy. For more information about how to become a member or participate in SBMT programs please visit: www.WorldBrainMapping.org
Publisher: Academic Press
ISBN: 9780124158184
Category : Science
Languages : en
Pages : 0
Book Description
The Marmoset Brain in Stereotaxic Coordinates is the most comprehensive atlas of the brain of this animal available. The atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most-cited book in neuroscience. It represents a collaboration between world leaders in neuroanatomy of the primate cortex and subcortex. It will be an indispensible tool for neuroanatomists, behavioral neuroscientists, and molecular biologists trying to understand the primate brain. ENDORSED BY SOCIETY FOR BRAIN MAPPING AND THERAPEUTICS (SBMT) - SBMT is a non-profit society organized for the purpose of encouraging basic and clinical scientists who are interested in areas of Brain Mapping, engineering, stem cell, nanotechnology, imaging and medical device to improve the diagnosis, treatment and rehabilitation of patients afflicted with neurological disorders. This society promotes the public welfare and improves patient care through the translation of new technologies/therapies into life saving diagnostic and therapeutic procedures. The Society is focused in breaking boundaries of science, technology, medicine, art and healthcare policy. For more information about how to become a member or participate in SBMT programs please visit: www.WorldBrainMapping.org
MRI Atlas of the Human Cerebellum
Author: Jeremy D. Schmahmann
Publisher: Academic Press
ISBN: 0080574076
Category : Medical
Languages : en
Pages : 187
Book Description
The MRI Atlas of the Human Cerebellum constitutes the most complete, detailed work on the human cerebellum to date. This definitive work provides images in the three cardinal planes (sagittal, transverse, and coronal) at closely spaced intervals of 2 millimeters. The images are derived from MRI scans of one individual and from postmortem sections of another. It is the only such atlas set within the universally accepted framework of the Talairach stereotaxic system, derived from standard landmarks in the brain. The book includes a new nomenclature system (labeling system) which is easier to use, aids in understanding the organization of the cerebellum, and is consistent with earlier work on the anatomy of the cerebellum in animals and the development of the human cerebellum in infants.Recent studies have shown that the cerebellum is involved in much more than motor coordination alone: also in higher functions including memory, language, emotion, and attention, as well as sensory discrimination. This atlas facilitates this new era of study of the cerebellum, allowing investigators to identify cerebellar structures with precision. Everyone concerned with the anatomy, function, or dysfunction of the cerebellum should have a copy.Key Features* Provides the most comprehensive, detailed, and authoritative atlas of the human cerebellum* Contains 110 MRI images and 110 corresponding cryosection images* Includes a CD with all of the images and text from the book, supported by both PC and Macintosh computer platforms* Developed within the universally accepted framework of the Talairach stereotaxic system* Contains detailed myelin- and Nissl-stained histology of major nuclei* Presents a new, easy-to-use nomenclature system* Allows investigators to identify structures with precision and to address detailed structure-function correlations
Publisher: Academic Press
ISBN: 0080574076
Category : Medical
Languages : en
Pages : 187
Book Description
The MRI Atlas of the Human Cerebellum constitutes the most complete, detailed work on the human cerebellum to date. This definitive work provides images in the three cardinal planes (sagittal, transverse, and coronal) at closely spaced intervals of 2 millimeters. The images are derived from MRI scans of one individual and from postmortem sections of another. It is the only such atlas set within the universally accepted framework of the Talairach stereotaxic system, derived from standard landmarks in the brain. The book includes a new nomenclature system (labeling system) which is easier to use, aids in understanding the organization of the cerebellum, and is consistent with earlier work on the anatomy of the cerebellum in animals and the development of the human cerebellum in infants.Recent studies have shown that the cerebellum is involved in much more than motor coordination alone: also in higher functions including memory, language, emotion, and attention, as well as sensory discrimination. This atlas facilitates this new era of study of the cerebellum, allowing investigators to identify cerebellar structures with precision. Everyone concerned with the anatomy, function, or dysfunction of the cerebellum should have a copy.Key Features* Provides the most comprehensive, detailed, and authoritative atlas of the human cerebellum* Contains 110 MRI images and 110 corresponding cryosection images* Includes a CD with all of the images and text from the book, supported by both PC and Macintosh computer platforms* Developed within the universally accepted framework of the Talairach stereotaxic system* Contains detailed myelin- and Nissl-stained histology of major nuclei* Presents a new, easy-to-use nomenclature system* Allows investigators to identify structures with precision and to address detailed structure-function correlations
Neuraxial Therapeutics
Author: Tony Yaksh
Publisher: Springer Nature
ISBN: 3031395581
Category : Medical
Languages : en
Pages : 829
Book Description
This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.
Publisher: Springer Nature
ISBN: 3031395581
Category : Medical
Languages : en
Pages : 829
Book Description
This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.
Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition
Author:
Publisher: ScholarlyEditions
ISBN: 1464964114
Category : Science
Languages : en
Pages : 1751
Book Description
Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Applied, Analytical, and Imaging Sciences Research. The editors have built Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Applied, Analytical, and Imaging Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Publisher: ScholarlyEditions
ISBN: 1464964114
Category : Science
Languages : en
Pages : 1751
Book Description
Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Applied, Analytical, and Imaging Sciences Research. The editors have built Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Applied, Analytical, and Imaging Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Applied, Analytical, and Imaging Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Cyto- and Myeloarchitectural Brain Atlas of the Ferret (Mustela putorius) in MRI Aided Stereotaxic Coordinates
Author: Susanne Radtke-Schuller
Publisher: Springer
ISBN: 3319766260
Category : Medical
Languages : en
Pages : 380
Book Description
Description This stereotaxic atlas of the ferret brain provides detailed architectonic subdivisions of the cortical and subcortical areas in the ferret brain using high-quality histological material stained for cells and myelin together with in vivo magnetic resonance (MR) images of the same animal. The skull-related position of the ferret brain was established according to in vivo MRI and additional CT measurements of the skull. Functional denotations from published physiology and connectivity studies are mapped onto the atlas sections and onto the brain surface, together with the architectonic subdivisions. High-resolution MR images are provided at levels of the corresponding histology atlas plates with labels of the respective brain structures. The book is the first atlas of the ferret brain and the most detailed brain atlas of a carnivore available to date. It provides a common reference base to collect and compare data from any kind of research in the ferret brain. Key Features Provides the first ferret brain atlas with detailed delineations of cortical and subcortical areas in frontal plane. Provides the most detailed brain atlas of a carnivore to date. Presents a stereotaxic atlas coordinate system derived from high-quality histological material and in vivo magnetic resonance (MR) images of the same animal. Covers the ferret brain from forebrain to spinal cord at intervals of 0.6 mm on 58 anterior-posterior levels with 5 plates each. Presents cell (Nissl) stained frontal sections (plate 1) and myelin stained sections (plate 2) in a stereotaxic frame. Provides detailed delineations of brain structures and their denomination on a Nissl stained background on a separate plate (3). Compiles abbreviations on plate 4, a plate that also displays the low resolution MRI of the atlas brain with the outlines of the Nissl sections in overlay. Displays high-resolution MR images at intervals of 0.15 mm from another animal with labeled brain structures as plate 5 corresponding to the anterior-posterior level of each atlas plate. Provides detailed references used for delineation of brain areas. Target audience of the book: The book addresses researchers and students in neurosciences who are interested in brain anatomy in general (e.g., for translational purposes/comparative aspects), particularly those who study the ferret as important animal model of growing interest in neurosciences.
Publisher: Springer
ISBN: 3319766260
Category : Medical
Languages : en
Pages : 380
Book Description
Description This stereotaxic atlas of the ferret brain provides detailed architectonic subdivisions of the cortical and subcortical areas in the ferret brain using high-quality histological material stained for cells and myelin together with in vivo magnetic resonance (MR) images of the same animal. The skull-related position of the ferret brain was established according to in vivo MRI and additional CT measurements of the skull. Functional denotations from published physiology and connectivity studies are mapped onto the atlas sections and onto the brain surface, together with the architectonic subdivisions. High-resolution MR images are provided at levels of the corresponding histology atlas plates with labels of the respective brain structures. The book is the first atlas of the ferret brain and the most detailed brain atlas of a carnivore available to date. It provides a common reference base to collect and compare data from any kind of research in the ferret brain. Key Features Provides the first ferret brain atlas with detailed delineations of cortical and subcortical areas in frontal plane. Provides the most detailed brain atlas of a carnivore to date. Presents a stereotaxic atlas coordinate system derived from high-quality histological material and in vivo magnetic resonance (MR) images of the same animal. Covers the ferret brain from forebrain to spinal cord at intervals of 0.6 mm on 58 anterior-posterior levels with 5 plates each. Presents cell (Nissl) stained frontal sections (plate 1) and myelin stained sections (plate 2) in a stereotaxic frame. Provides detailed delineations of brain structures and their denomination on a Nissl stained background on a separate plate (3). Compiles abbreviations on plate 4, a plate that also displays the low resolution MRI of the atlas brain with the outlines of the Nissl sections in overlay. Displays high-resolution MR images at intervals of 0.15 mm from another animal with labeled brain structures as plate 5 corresponding to the anterior-posterior level of each atlas plate. Provides detailed references used for delineation of brain areas. Target audience of the book: The book addresses researchers and students in neurosciences who are interested in brain anatomy in general (e.g., for translational purposes/comparative aspects), particularly those who study the ferret as important animal model of growing interest in neurosciences.
Neuroprosthetics
Author: Justin C. Sanchez
Publisher: CRC Press
ISBN: 1466553243
Category : Medical
Languages : en
Pages : 236
Book Description
Master the tools of design thinking using Neuroprosthetics: Principles and Applications. Developed from successfully tested material used in an undergraduate and graduate level course taught to biomedical engineering and neuroscience students, this book focuses on the use of direct neural sensing and stimulation as a therapeutic intervention for complex disorders of the brain. It covers the theory and applications behind neuroprosthetics and explores how neuroprosthetic design thinking can enhance value for users of a direct neural interface. The book explains the fundamentals of design thinking, introduces essential concepts from neuroscience and engineering illustrating the major components of neuroprosthetics, and presents practical applications. In addition to describing the approach of design thinking (based on facts about the user’s needs, desires, habits, attitudes, and experiences with neuroprosthetics), it also examines how effectively "human centered" neuroprosthetics can address people’s needs and interactions in their daily lives. Identifying concepts and features of devices that work well with users of a direct neural interface, this book: Outlines the signal sensing capabilities and trade-offs for common electrode designs, and determines the most appropriate electrode for any neuroprosthetic application Specifies neurosurgical techniques and how electronics should be tailored to capture neural signals Provides an understanding of the mechanisms of neural–electrode performance and information contained in neural signals Provides understanding of neural decoding in neuroprosthetic applications Describes the strategies that can be used to promote long-term therapeutic interventions for humans through the use of neuroprosthetics The first true primary text for undergraduate and graduate students in departments of neuroscience and bioengineering that covers the theory and applications behind this science, Neuroprosthetics: Principles and Applications provides the fundamental knowledge needed to understand how electrodes translate neural activity into signals that are useable by machines and enables readers to master the tools of design thinking and apply them to any neuroprosthetic application.
Publisher: CRC Press
ISBN: 1466553243
Category : Medical
Languages : en
Pages : 236
Book Description
Master the tools of design thinking using Neuroprosthetics: Principles and Applications. Developed from successfully tested material used in an undergraduate and graduate level course taught to biomedical engineering and neuroscience students, this book focuses on the use of direct neural sensing and stimulation as a therapeutic intervention for complex disorders of the brain. It covers the theory and applications behind neuroprosthetics and explores how neuroprosthetic design thinking can enhance value for users of a direct neural interface. The book explains the fundamentals of design thinking, introduces essential concepts from neuroscience and engineering illustrating the major components of neuroprosthetics, and presents practical applications. In addition to describing the approach of design thinking (based on facts about the user’s needs, desires, habits, attitudes, and experiences with neuroprosthetics), it also examines how effectively "human centered" neuroprosthetics can address people’s needs and interactions in their daily lives. Identifying concepts and features of devices that work well with users of a direct neural interface, this book: Outlines the signal sensing capabilities and trade-offs for common electrode designs, and determines the most appropriate electrode for any neuroprosthetic application Specifies neurosurgical techniques and how electronics should be tailored to capture neural signals Provides an understanding of the mechanisms of neural–electrode performance and information contained in neural signals Provides understanding of neural decoding in neuroprosthetic applications Describes the strategies that can be used to promote long-term therapeutic interventions for humans through the use of neuroprosthetics The first true primary text for undergraduate and graduate students in departments of neuroscience and bioengineering that covers the theory and applications behind this science, Neuroprosthetics: Principles and Applications provides the fundamental knowledge needed to understand how electrodes translate neural activity into signals that are useable by machines and enables readers to master the tools of design thinking and apply them to any neuroprosthetic application.