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Author: Allan V. Kalueff
Publisher: Humana Press
ISBN: 9781607619215
Category : Medical
Languages : en
Pages : 296
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Book Description
Animal models have traditionally played a crucial role in improving our understanding of brain pathogenesis. Zebrafish (Danio rerio) have generated considerable discoveries in the areas of genetics, embryology, endocrinology, and neuroscience. Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models. Written by leading international experts, the book covers major topics ranging from stress to learned recognition of environment, encompassing a wide spectrum of the utility of zebrafish within neurobiological disciplines. The chapters provide authoritative reviews of many zebrafish paradigms commonly used in the field today. This book will be a useful guide for zebrafish researchers, and will complement another related book from the popular Neuromethods series, Zebrafish Neurobehavioral Protocols. Comprehensive and up-to-date, Zebrafish Models in Neurobehavioral Research serves as an ideal resource for scientists new to the field as well as for established researchers seeking valuable insight into the growing utility of zebrafish in neuroscience.
Author: Allan V. Kalueff
Publisher: Humana Press
ISBN: 9781607619215
Category : Medical
Languages : en
Pages : 296
Get Book Here
Book Description
Animal models have traditionally played a crucial role in improving our understanding of brain pathogenesis. Zebrafish (Danio rerio) have generated considerable discoveries in the areas of genetics, embryology, endocrinology, and neuroscience. Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models. Written by leading international experts, the book covers major topics ranging from stress to learned recognition of environment, encompassing a wide spectrum of the utility of zebrafish within neurobiological disciplines. The chapters provide authoritative reviews of many zebrafish paradigms commonly used in the field today. This book will be a useful guide for zebrafish researchers, and will complement another related book from the popular Neuromethods series, Zebrafish Neurobehavioral Protocols. Comprehensive and up-to-date, Zebrafish Models in Neurobehavioral Research serves as an ideal resource for scientists new to the field as well as for established researchers seeking valuable insight into the growing utility of zebrafish in neuroscience.
Author: Allan V. Kalueff
Publisher: Humana Press
ISBN: 9781617795961
Category : Medical
Languages : en
Pages : 0
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Book Description
Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. That, along with their low cost, easy manipulation, short reproductive cycles, and physiological homology to humans, has made zebrafish a vital model organism for neuroscience research. Zebrafish Protocols for Neurobehavioral Research addresses protocols for both larval and adult models, written by the leading experts in the field of zebrafish research. Part I of this book takes advantage of the high-throughput nature of larval models to offer protocols for research requiring high output, easily manipulated screens. The second half of the book focuses on the robust and sophisticated behaviors of adult zebrafish, suitable for the neurophenotyping of complex traits and multi-domain disorders. Importantly, these models complement each other, working together to provide researchers with valuable insights into neurobiology of normal and pathological behavior. Thorough and cutting-edge, this volume is a useful, authoritative reference guide that should hold a coveted spot in zebrafish laboratories across the globe.
Author: Allan V. Kalueff
Publisher: Humana Press
ISBN: 9781607619543
Category : Medical
Languages : en
Pages : 206
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Book Description
As a model organism, zebrafish (Danio rerio) offer an opportunity to perform steadfast scientific investigations in a robust and high-throughput manner. In Zebrafish Neurobehavioral Protocols, experts in the field provide a series of detailed behavioral protocols dealing with the major current research areas in the field of behavioral neuroscience. The chapters discuss the use and interpretation of video-aided quantification of zebrafish behaviors, describe novel assays commonly used to quantify emotionality, learning, memory, and social behaviors in zebrafish, and instruct how to quantify endocrine responses and correlate them with behavior. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. This "how to" book will be a useful practical guide for zebrafish researchers and will complement another related book from this series, Zebrafish Models in Neurobehavioral Research. Cutting-edge and timely, Zebrafish Neurobehavioral Protocols serves as an excellent compilation epitomizing the growing potential of zebrafish in modern scientific inquiry.
Author: Jerry J. Buccafusco
Publisher: CRC Press
ISBN: 1420041819
Category : Medical
Languages : en
Pages : 341
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Book Description
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Author: Robert T. Gerlai
Publisher: Academic Press
ISBN: 012817529X
Category : Medical
Languages : en
Pages : 616
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Book Description
Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. - Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field - Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish - Features examples of zebrafish models of human central nervous system disorders - Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Author: Allan V. Kalueff
Publisher: Springer
ISBN: 9783319337739
Category : Medical
Languages : en
Pages : 0
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Book Description
Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Author: Geoffrey A. Manley
Publisher: Springer Science & Business Media
ISBN: 1441989579
Category : Science
Languages : en
Pages : 433
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Book Description
The function of vertebrate hearing is served by a surprising variety of sensory structures in the different groups of fish, amphibians, reptiles, birds, and mammals. This book discusses the origin, specialization, and functional properties of sensory hair cells, beginning with environmental constraints on acoustic systems and addressing in detail the evolutionary history behind modern structure and function in the vertebrate ear. Taking a comparative approach, chapters are devoted to each of the vertebrate groups, outlining the transition to land existence and the further parallel and independent adaptations of amniotic groups living in air. The volume explores in depth the specific properties of hair cells that allowed them to become sensitive to sound and capable of analyzing sounds into their respective frequency components. Evolution of the Vertebrate Auditory System is directed to a broad audience of biologists and clinicians, from the level of advanced undergraduate students to professionals interested in learning more about the evolution, structure, and function of the ear.
Author: Valter Tucci
Publisher: John Wiley & Sons
ISBN: 1118540719
Category : Medical
Languages : en
Pages : 648
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Book Description
The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., “systems biology” approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.
Author: Robert T. Gerlai
Publisher: Academic Press
ISBN: 0128041161
Category : Science
Languages : en
Pages : 710
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Book Description
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials - Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior - Written and edited by leading international experts
Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 0128092963
Category : Medical
Languages : en
Pages : 416
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Book Description
Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual's lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances. - Integrates current research on the actions of addictive substances in neurological disease - Includes functional foods, such as caffeine beverages, that have habituating effects on the brain - Provides a synopsis of key ideas associated with the consequences of addictive and habituating lifestyle substances
