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Author: Samuel Cartner
Publisher: Academic Press
ISBN: 0128124326
Category : Science
Languages : en
Pages : 720
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Book Description
The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. - Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications - Includes the work of world-renowned authors - Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Author: Samuel Cartner
Publisher: Academic Press
ISBN: 0128124326
Category : Science
Languages : en
Pages : 720
Get Book Here
Book Description
The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. - Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications - Includes the work of world-renowned authors - Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Author: Allan V. Kalueff
Publisher: Humana Press
ISBN: 9781607619215
Category : Medical
Languages : en
Pages : 296
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Book Description
Animal models have traditionally played a crucial role in improving our understanding of brain pathogenesis. Zebrafish (Danio rerio) have generated considerable discoveries in the areas of genetics, embryology, endocrinology, and neuroscience. Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models. Written by leading international experts, the book covers major topics ranging from stress to learned recognition of environment, encompassing a wide spectrum of the utility of zebrafish within neurobiological disciplines. The chapters provide authoritative reviews of many zebrafish paradigms commonly used in the field today. This book will be a useful guide for zebrafish researchers, and will complement another related book from the popular Neuromethods series, Zebrafish Neurobehavioral Protocols. Comprehensive and up-to-date, Zebrafish Models in Neurobehavioral Research serves as an ideal resource for scientists new to the field as well as for established researchers seeking valuable insight into the growing utility of zebrafish in neuroscience.
Author: Christiane Nusslein-Volhard
Publisher: Oxford University Press
ISBN: 9780199638086
Category : Science
Languages : en
Pages : 342
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Book Description
The zebrafish has become one of the most important model organisms to study biological processes within a living body. As a vertebrate that has many of the strengths of invertebrate model systems, it offers numerous advantages to researchers interested in many aspects of embryonic development, physiology and disease. This book not only provides a complete set of instructions that will allow researchers to establish the zebrafish in their laboratory. It also gives a broad overview of commonly used methods and a comprehensive collection of protocols describing the most powerful techniques.
Author: Joseph A. Holden
Publisher: Cambridge University Press
ISBN: 1139620630
Category : Science
Languages : en
Pages : 157
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Book Description
The zebrafish (Danio rerio) is a valuable and common model for researchers working in the fields of genetics, oncology and developmental sciences. This full-color atlas will aid experimental design and interpretation in these areas by providing a fundamental understanding of zebrafish anatomy. Over 150 photomicrographs are included and can be used for direct comparison with histological slides, allowing quick and accurate identification of the anatomic structures of interest. Hematoxylin and eosin stained longitudinal and transverse sections demonstrate gross anatomic relationships and illustrate the microscopic anatomy of major organs. Unlike much of the current literature, this book is focused exclusively on the zebrafish, eliminating the need for researchers to exclude structures that are only found in other fish.
Author: Monte Westerfield
Publisher: Academic Press
ISBN: 0080923437
Category : Science
Languages : en
Pages : 581
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Book Description
Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is the prime model for genetic and developmental studies, as well as research in genomics. While genetically distant from humans, nonetheless the vertebrate zebrafish has comparable organs and tissues that make it the model organism for study of vertebrate development.This book, one of two new volumes in the Reliable Lab Solutions series dealing with zebrafish, brings together a robust and up-to-date collection of time-tested methods presented by the world's leading scientists. Culled from previously published chapters in Methods in Cell Biology and updated by the original authors where relevant, it provides a comprehensive collection of protocols describing the most widely used techniques relevant to the study of the cellular and developmental biology of zebrafish. The methods in this volume were hand-selected by the editors, whose goal was to a provide a handy and cost-effective collection of fail-safe methods, tips, and "tricks of the trade to both experienced researchers and more junior members in the lab. - Provides busy researchers a quick reference for time-tested methods and protocols that really work, updated where possible by the original authors - Gives pragmatic wisdom to the non-specialist from experts in the field with years of experience with trial and error
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470319429
Category : Science
Languages : en
Pages : 260
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Book Description
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Author: Robert Bryson-Richardson
Publisher: Academic Press
ISBN: 0080920616
Category : Science
Languages : en
Pages : 239
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Book Description
Zebrafish are widely considered an excellent model system for vertebrate development. The embryo is transparent, thereby enabling visualization and use of labelling and transgenic approaches. Moreover, because of the ease of inducing new mutations in zebrafish and similarity with the human genome, this organism may be used effectively for disease studies. For example, mutant zebrafish are being utilized for testing drugs that will combat a range of human diseases, from Alzheimer's and cancer to kidney failure and congenital heart disease. For the first time, this atlas provides the research community with a complete reference for zebrafish anatomy spanning the early embryo all the way to adulthood. The authors employ the technique of optical projection tomography (OPT), and offer a series of sections in multiple planes from each sample. The contents are organized by developmental stages, with over 200 images that contain annotations describing anatomical structures relevant to development. In addition, chapters feature explanatory text that highlights major developments in the zebrafish during each stage. - Provides the first comprehensive anatomical resource that covers all regions of zebrafish anatomy from the larval period to adulthood - The over 200 images include explanatory notes - Each chapter contains a concise description of key anatomical features that factor in zebrafish development - Despite many years of use as a model system, until now there has never been a guide to zebrafish at the larval stage - The book's website contains a database of over 10k sections from different regions as well as 3D images that are interactive
Author: Robert T. Gerlai
Publisher: Academic Press
ISBN: 9780128175286
Category : Medical
Languages : en
Pages : 800
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Book Description
The past decade has seen a rapid accumulation of knowledge on the behavioral characteristics of zebrafish, and increased investigation into the neurobiological basis of behavior using zebrafish. This simple vertebrate represents an ideal compromise between system complexity and practical simplicity, with its mammalian sequence homology, fecundity, and conveniently small size and transparent embryology. Behavioral and Neural Genetics of Zebrafish assembles state of the art methodologies and the most current concepts pertinent to the neurobehavioral genetics of zebrafish. Discussing its natural behavior, motor function, and learning and memory, it focuses on the fry and adult zebrafish and features a comprehensive account of modern genetic and neural methods adapted to or specifically developed for Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish will be presented, as well as a section on bioinformatics and "big-data" related questions. Focusing on this excellent translational tool, this book examines a species with which investigators may model and analyze even such complex human diseases as those associated with brain dysfunction. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes description of behavioral, genetic, and neural methods and concepts and adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Author: Claudia Harper
Publisher: CRC Press
ISBN: 1439807442
Category : Medical
Languages : en
Pages : 260
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Book Description
Like other books in the Laboratory Animal Pocket Reference Series, this guide covers all aspects pertaining to the use of these organisms including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management. In the relatively brief span
Author: Hajime Kojima
Publisher: Springer
ISBN: 9811324476
Category : Medical
Languages : en
Pages : 136
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Book Description
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
