Viability of Human Uterine Transplant PDF Download
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Author: Jewel Sawyer
Publisher:
ISBN:
Category :
Languages : en
Pages : 90
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Book Description
Problem: Uterine factor infertility is most commonly a result of congenital malformations or previous hysterectomy which leaves women without a functional uterus. Currently, the only options available for this form of infertility are adoption or surrogacy; however, they may not be suitable for women with political or religious prohibitions or those who desperately desire to conceive and carry their own biological children. Therefore, uterus transplant may be an option for these women if organ transplantation is acceptable. To date, there have been various animal studies but only one human trial that examines whether uterine transplant can be successfully performed. The purpose of this literature review is to assess if a surgical technique has been developed that could lead to viable human uterine transplant in the future. Methods: A literature search regarding uterine transplantation over the past ten years was performed in the Weill Cornell Medical College Online library. Search terms used include "uterine transplant", "human" and "uterine transplant", "uterus" and" transplant", "human uterine transplant", "infertility" and "transplant", and "uterine factor infertility". Results: Every study analyzed concluded that uterine transplantation could be successfully performed if a modified technique was employed. It was also found that there are specific markers of rejection such as an increase in neutrophils that could be assessed in order to offset the rejection pattern with the use of adequate immunosuppression. Conclusions: Further research on the use of elongated vascular pedicles, adequate uterine support and immunotherapy will likely significantly improve uterine transplant viability.
Author: Jewel Sawyer
Publisher:
ISBN:
Category :
Languages : en
Pages : 90
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Book Description
Problem: Uterine factor infertility is most commonly a result of congenital malformations or previous hysterectomy which leaves women without a functional uterus. Currently, the only options available for this form of infertility are adoption or surrogacy; however, they may not be suitable for women with political or religious prohibitions or those who desperately desire to conceive and carry their own biological children. Therefore, uterus transplant may be an option for these women if organ transplantation is acceptable. To date, there have been various animal studies but only one human trial that examines whether uterine transplant can be successfully performed. The purpose of this literature review is to assess if a surgical technique has been developed that could lead to viable human uterine transplant in the future. Methods: A literature search regarding uterine transplantation over the past ten years was performed in the Weill Cornell Medical College Online library. Search terms used include "uterine transplant", "human" and "uterine transplant", "uterus" and" transplant", "human uterine transplant", "infertility" and "transplant", and "uterine factor infertility". Results: Every study analyzed concluded that uterine transplantation could be successfully performed if a modified technique was employed. It was also found that there are specific markers of rejection such as an increase in neutrophils that could be assessed in order to offset the rejection pattern with the use of adequate immunosuppression. Conclusions: Further research on the use of elongated vascular pedicles, adequate uterine support and immunotherapy will likely significantly improve uterine transplant viability.
Author: Mats Brännström
Publisher: Springer Nature
ISBN: 3319941623
Category : Health & Fitness
Languages : en
Pages : 226
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Book Description
This book discusses all aspects of the uterus transplantation procedure in women who are childless because of a dysfunctional or missing uterus, from initial pre-operative investigations to follow-up after the uterine graft has been removed. All the international experts who are engaged in clinical activities and/or research in this field have contributed one or more of the book’s chapters. Since the first live birth following uterus transplantation was reported in Sweden in September 2014, the field has been rapidly evolving around the globe: the first cases in USA, Germany, China, Brazil, and Czech Republic were performed in 2016 and several other centres are preparing for clinical trials of uterus transplantation. Uterus transplantation is a subject that attracts the attention of many bioethicists, and like all other major procedures in transplantation surgery and assisted reproduction techniques, it is a complex process that requires a multidisciplinary team if it is to be successful. As such the book is a valuable resource not only for clinicians from many disciplines, but also for nurses, ethicists, psychologists and researchers.
Author: Amel Alghrani
Publisher: Cambridge University Press
ISBN: 1107160561
Category : Health & Fitness
Languages : en
Pages : 305
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Book Description
Examines emerging assisted reproductive technologies that will revolutionise the future of human reproduction and their regulation.
Author: Peter M. Fayers
Publisher: John Wiley & Sons
ISBN: 1118699459
Category : Medical
Languages : en
Pages : 460
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Book Description
Quality of life studies form an essential part of the evaluation of any treatment. Written by two authors who are well respected within this field, Quality of Life: The Assessment, Analysis and Interpretation of Patient-reported Outcomes, Second Edition lays down guidelines on assessing, analysing and interpreting quality of life data. The new edition of this standard book has been completely revised, updated and expanded to reflect many methodological developments emerged since the publication of the first edition. Covers the design of instruments, the practical aspects of implementing assessment, the analyses of the data, and the interpretation of the results Presents all essential information on Quality of Life Research in one comprehensive volume Explains the use of qualitative and quantitative methods, including the application of basic statistical methods Includes copious practical examples Fills a need in a rapidly growing area of interest New edition accommodates significant methodological developments, and includes chapters on computer adaptive testing and item banking, choosing an instrument, systematic reviews and meta analysis This book is of interest for everyone involved in quality of life research, and it is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and practitioners in the fields of cancer and other chronic diseases. Reviews of the First Edition – Winner of the first prize in the Basis of Medicine Category of the BMA Medical Book Competition 2001: “This book is highly recommended to clinicians who are actively involved in the planning, analysis and publication of QoL research.” CLINICAL ONCOLOGY “This book is highly recommended reading.” QUALITY OF LIFE RESEARCH
Author: David Price
Publisher: Routledge
ISBN: 135191345X
Category : Law
Languages : en
Pages : 605
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Book Description
Organ transplantation has been one of the miracles of modern-day medicine but, in addition to presenting enormous technical and clinical challenges, it throws up major ethical and legal issues principally from the perspective of the donor. Evolving capabilities in the spheres of both organ and tissue transplantation, coupled with rapidly-escalating demand, assert consistent and critical pressure on our ethical and legal principles and frameworks, including the expansion of the potential donor pool beyond the conventional categories of donor. This volume brings together seminal papers analyzing such matters in the context of an ever-increasingly important area of clinical practice.
Author: Jacques Donnez
Publisher: Cambridge University Press
ISBN: 1139496123
Category : Medical
Languages : en
Pages : 569
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Book Description
The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.
Author: David K. Gardner
Publisher: CRC Press
ISBN: 1482260697
Category : Medical
Languages : en
Pages : 970
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Book Description
Textbook of Assisted Reproductive Techniques has become a classic comprehensive reference for the whole team at the IVF clinic. The fourth edition comes more conveniently as a set of two separate volumes, one for laboratory aspects and the other for clinical applications. The text has been extensively revised, with the addition of several important new contributions on laboratory aspects including developing techniques such as PICSI, IMSI, and time-lapse imaging. The second volume focuses on clinical applications and includes new chapters on lifestyle factors, tailored ovarian stimulation, frozen-thawed embryo transfer, viral disease, and religious perspectives. As before, methods, protocols, and techniques of choice are presented by eminent international experts. The two volume set includes: ■ Volume One - Laboratory Perspectives ■ Volume Two - Clinical Perspectives
Author: Vassyl A. Lonchyna
Publisher: Springer Nature
ISBN: 3030846253
Category : Medical
Languages : en
Pages : 743
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Book Description
This book provides a detailed guide to the ethical considerations involved when making decisions in surgery. Chapters feature a uniform format, which feature a case that represents a real-life problem, discussion of the medical indications of that issue, the latest available medical solutions, and related ethical considerations. In some cases, more in-depth debate is provided on why a particular decision should or should not be made based-upon ethical principles. Information boxes containing key statements and relevant data in clear easy-to-digest tables facilitates the reader in being able to assimilate the most important points covered in each chapter. Difficult Decisions in Surgical Ethics: An Evidence-Based Approach is a thorough review of ethical considerations in a range of surgical scenarios encompassing both adult and pediatric topics, training surgical residents, ethical care during a pandemic, critical care, palliative care, sensitivity to religious and ethnic mores, clinical research, and innovation. It is intended to be a vital resource for practicing and trainee surgeons seeking a comprehensive up-to-date resource on ethical topics in surgical practice. The work is part of the Difficult Decisions in Surgery series covering a range of surgical specialties.
Author: The Royal Society
Publisher: National Academies Press
ISBN: 0309671132
Category : Medical
Languages : en
Pages : 239
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Book Description
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author: Maria Z. Siemionow
Publisher: Springer
ISBN: 1447163354
Category : Medical
Languages : en
Pages : 634
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Book Description
There is a paradigm shift in plastic and reconstructive surgery from the interest of developing new surgical techniques into the application of new technologies via research based studies on stem cells, tissue engineering and new field of reconstructive transplantation such as e.g. face, hand or larynx transplants. This approach is relatively novel and introduced to plastic surgery within past decade. Thus there is an urgent need to facilitate access to this new knowledge which was not traditionally a part of plastic surgery curriculum. The most efficient way of introducing these new approaches is via presentation of pertinent to different fields (stem cell, transplantation, nerve regeneration, tissue engineering) experimental models which can be used as a tool to develop technologies of interest by different groups of surgeons. These surgical specialities which will be interested and benefit from the book include: plastic and reconstructive surgeons, microsurgeons, hand surgeons, orthopaedic surgeons, neurosurgeons and transplant surgeons.
