Author: Jiguang WangPublisher: Leuven University Press
ISBN: 9789058673992
Category :
Languages : en
Pages : 206
Book Description
Variation in Sodium-Regulating Genes in Relation to Blood Pressure and Associated Phenotypes in Caucasians and Chinese
Author: Jiguang WangPublisher: Leuven University Press
ISBN: 9789058673992
Category :
Languages : en
Pages : 206
Book Description
Genetic Variation and Environmental Factors in Biological and Arterial Ageing
Author: Tim NawrotPublisher: Leuven University Press
ISBN: 9789058674609
Category : Medical
Languages : en
Pages : 168
Book Description
Ageing, the decline in survival and bodily functions, caused by damage to macromolecules and tissues is intrinsically linked to life. Although universal and unavoidable, ageing does not occur in a uniform way. In the general population, it is actually a continuously distributed phenotype, in which genetic as well as environmental factors play an interactive role and explain the large interindividual differences between biological and chronological age. Cardiovascular disorders, which find there origins in deterioration of the structure and function of the large arteries, explain a large part of morbidity and mortality in industrialized societies. In this doctoral dissertation, the focus was on telomere length and arterial stiffness as biomarkers of biological and arterial ageing, respectively. It was investigated to what extent genetic and environmental determinants of oxidative stress and inflammation impact on the ageing process. Contents include: Introduction, Arterial ageing in cardiovascular risk prediction, Genetic and environmental factors in biological and arterial ageing, Telomere length and possible link to X chromosome, Role of smoking, oxidative stress and the -174 G/C interleukin-6 polymorphism in biological and vascular ageing, Environmental factors in arterial ageing, Blood pressure and blood selenium: a cross-sectional and a longitudinal population study, Endothelial function and outdoor temperature, General Discussion, Summary, Short Curriculum Vitae.
Generation and Characterization of a Mouse Model for a Sodium Channel Based Long QT Syndrome (LQT3)
Author: Dieter NuyensPublisher: Leuven University Press
ISBN: 9789058675309
Category : Medical
Languages : en
Pages : 142
Book Description
Mechanism and Role of Cyclooxygenase-2 Up-Regulation by Photodynamic Therapy
Author: Nico HendrickxPublisher: Leuven University Press
ISBN: 9789058675286
Category : Medical
Languages : en
Pages : 154
Book Description
Role of Nitric Oxide Synthase in the Regulation of Pulmonary Vascular Tone
Author: Leifu JiangPublisher: Leuven University Press
ISBN: 9789058675422
Category : Medical
Languages : en
Pages : 128
Book Description
Nitric Oxide and Cytochrome P450 Signaling in Experimental Pulmonary Hypertension
Author: Peter PokreiszPublisher: Leuven University Press
ISBN: 9789058675668
Category :
Languages : en
Pages : 136
Book Description
Regulation of the Antibody Response to Pneumococcal Capsular Polysaccharides
Author: Axel JeurissenPublisher: Leuven University Press
ISBN: 9789058674487
Category : Medical
Languages : en
Pages : 180
Book Description
This is a Ph.D. dissertation. S. pneumoniae is a major causative agent of serious infections. Besides, the emerging resistance of S. pneumoniae to multiple antibiotic drugs is a major concern in the treatment of infections caused by this micro-organism. Therefore it is important to study the molecular mechanisms that meditate the antibody response to caps-PS. The aim of the study is to better understand the regulation and the molecular mechanisms of the immune response to pneumococcal caps-PS. The present study was undertaken to determine the role of the CD40-CD40L interaction in the murine antibody response to pneumococcal caps-PS antigens.
Genetic Modulators of Pulmonary Function in Cystic Fibrosis and Genetic Susceptibility Factors of Emphysema
Author: Jennifer S. YardenPublisher: Leuven University Press
ISBN: 9789058674807
Category : Medical
Languages : en
Pages : 192
Book Description
Cardioselective Nitric Oxide Synthase Gene Transfer to Target Myocardial Ischemia
Author: Zsolt SzelidPublisher: Leuven University Press
ISBN: 9789058674548
Category : Medical
Languages : en
Pages : 116
Book Description
This is a Ph.D. dissertation. Introduction: Cardiovascular and myocardial gene transfer, Gene delivery strategies to the cardiovascular system, Gene vector design, Adenovirus-mediated immunity and cardiovascular gene transfer, Myocardial gene transfer to target myocardial ischemia - reperfusion injury; Specific aims; Materials and methods: Construction of recombinant virus, Myocardial transfer and anti-adenoviral immunity, Gene transfer and myocardial ischemia-reperfusion injury, Statistical analysis; Results: Anti-adenoviral immunity and myocardial adenoviral gene transfer, Gene transfer and myocardial ischemia-reperfusion injury; Discussion: Pre-existing anti-adenoviral immunity and adenovirus-mediated myocardial gene transfer, Intramyocardial NOS3 gene transfer and adenovirus-mediated immune responses, Cardioselective NOS3 gene transfer and myocardial protection from reperfusion injury; General conclusions.
Genetic Analysis of Herpesvirus Entry Receptors and Host Susceptibility to Herpes Simplex Virus Infection
Author: Frank StruyfPublisher: Leuven University Press
ISBN: 9789058674012
Category : Medical
Languages : en
Pages : 142
Book Description
