Validation Study of a Target Identification Model PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Validation Study of a Target Identification Model PDF full book. Access full book title Validation Study of a Target Identification Model by Leonard A. Evans. Download full books in PDF and EPUB format.
Author: Leonard A. Evans
Publisher:
ISBN:
Category :
Languages : en
Pages : 37
Get Book Here
Book Description
A research program was undertaken to assess the validity of a previously developed mathematical model for predicting target identification probabilities. A major validation study and three auxiliary studies were conducted. The purpose of the validation study was to compare predictions of the model with empirically obtained probabilities. Stimulus materials were generated by filming a TV monitor screen upon which was presented the scene being viewed by a TV camera as it swept over a terrain model containing various targets of differing surround and contrast. These materials were subsequently projected at three different projection speeds and viewed from each of three different distances by three groups of twenty subjects. Empirical probabilities for each of 54 'flight' conditions (involving variations in contrast, resolution ratio, target angular subtense, and viewing time) were experimentally obtained and were compared with probabilities estimated from these factors by a mathematical model of target identification performance. The three auxiliary studies were designed to investigate specific assumptions or aspects of the target identification model. Specifically, they were to determine (1) whether the predicted probability of target identification is a function of display mode (static or dynamic); (2) whether performance is a function of target size independent of the relative proportion of the field of view occupied by the target; and (3) whether the target identification model predicts equally well for two different levels of system resolution. (Author).
Author: Leonard A. Evans
Publisher:
ISBN:
Category :
Languages : en
Pages : 37
Get Book Here
Book Description
A research program was undertaken to assess the validity of a previously developed mathematical model for predicting target identification probabilities. A major validation study and three auxiliary studies were conducted. The purpose of the validation study was to compare predictions of the model with empirically obtained probabilities. Stimulus materials were generated by filming a TV monitor screen upon which was presented the scene being viewed by a TV camera as it swept over a terrain model containing various targets of differing surround and contrast. These materials were subsequently projected at three different projection speeds and viewed from each of three different distances by three groups of twenty subjects. Empirical probabilities for each of 54 'flight' conditions (involving variations in contrast, resolution ratio, target angular subtense, and viewing time) were experimentally obtained and were compared with probabilities estimated from these factors by a mathematical model of target identification performance. The three auxiliary studies were designed to investigate specific assumptions or aspects of the target identification model. Specifically, they were to determine (1) whether the predicted probability of target identification is a function of display mode (static or dynamic); (2) whether performance is a function of target size independent of the relative proportion of the field of view occupied by the target; and (3) whether the target identification model predicts equally well for two different levels of system resolution. (Author).
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 37
Get Book Here
Book Description
A research program was undertaken to assess the validity of a previously developed mathematical model for predicting target identification probabilities. A major validation study and three auxiliary studies were conducted. The purpose of the validation study was to compare predictions of the model with empirically obtained probabilities. Stimulus materials were generated by filming a TV monitor screen upon which was presented the scene being viewed by a TV camera as it swept over a terrain model containing various targets of differing surround and contrast. These materials were subsequently projected at three different projection speeds and viewed from each of three different distances by three groups of twenty subjects. Empirical probabilities for each of 54 'flight' conditions (involving variations in contrast, resolution ratio, target angular subtense, and viewing time) were experimentally obtained and were compared with probabilities estimated from these factors by a mathematical model of target identification performance. The three auxiliary studies were designed to investigate specific assumptions or aspects of the target identification model. Specifically, they were to determine (1) whether the predicted probability of target identification is a function of display mode (static or dynamic); (2) whether performance is a function of target size independent of the relative proportion of the field of view occupied by the target; and (3) whether the target identification model predicts equally well for two different levels of system resolution. (Author).
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309292492
Category : Medical
Languages : en
Pages : 107
Get Book Here
Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author: Jurgen Moll
Publisher: Humana Press
ISBN: 9781493962785
Category : Medical
Languages : en
Pages : 388
Get Book Here
Book Description
This Methods in Molecular Biology book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports."
Author: Alleyn T. Plowright
Publisher: John Wiley & Sons
ISBN: 3527345299
Category : Medical
Languages : en
Pages : 396
Get Book Here
Book Description
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
Author: Marcus T. Scotti
Publisher: Springer Nature
ISBN: 3030958957
Category : Medical
Languages : en
Pages : 266
Get Book Here
Book Description
The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
Author: Mouldy Sioud
Publisher: Springer Science & Business Media
ISBN: 1597451657
Category : Medical
Languages : en
Pages : 360
Get Book Here
Book Description
Target discovery is a field that has existed for several years but is so vibrant today because of the recent progress in our understanding of the molecular mechanisms of many human diseases and the technical advances in target identification and validation. More sophisticated gene profiling technologies, such as DNA microarrays and serial analysis of gene expression, permit rapid identification of lead targets. Moreover, analysis of gene networks in living organisms allows the identification of target genes that operate in defined physiological pathways. With the sequencing of several genomes completed and the rapidly growing gene expression databases, there is now greater impetus than ever before for in silico discovery of therapeutic targets. Also, recent advances in genetic technologies have increased our ability to generate mouse models for human diseases. The implications of these genetically modified animals in drug development are several, including identification of new drug targets, predicting efficacy, and uncovering possible side effects. Together, these recent technical advances should allow researchers to make the most informed choice early and advance the chosen targets toward clinical studies. Regarding cancers, any difference between a cancer and a normal cell could potentially be exploited as a therapeutic target. The hope is that drugs targeting specific constituents or pathways in cancer cells will provide more effective therapy, either alone or in combination with other currently used anticancer drugs. In addition to drug targets, identifying new target antigens remains as much of a challenge as improving tumor vaccines already in the clinic.
Author: Eli Peli
Publisher: World Scientific
ISBN: 9789810221492
Category : Technology & Engineering
Languages : en
Pages : 438
Get Book Here
Book Description
This book is an international collection of contributions from academia, industry and the armed forces. It addresses current and emerging Spatial Vision Models and their application to the understanding, prediction and evaluation of the tasks of target detection and recognition. The discussion in many of the chapters is framed in terms of military targets and military vision aids. However, the techniques analyses and problems are by no means limited to this area of application. The detection and recognition of an armored vehicle from a reconnaissance image are performed by the same visual system used to detect and recognize a tumor in an X-ray. The analysis of the interaction of the human visual system with night vision devices is not different from the analysis needed in the case of an operator examining structures using a remote (endoscopic) camera, etc. The book is organized into three general sections. The first covers basic modeling of central (foveal) vision and its theoretical background. The second is centered on the evaluation of model performance in applications, while the third is dedicated to aspects of peripheral vision modeling and the expansion of peripheral modeling to include visual search.
Author: Darryl Leon
Publisher: CRC Press
ISBN: 1420015737
Category : Medical
Languages : en
Pages : 510
Get Book Here
Book Description
The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Ide
Author: Mouldy Sioud
Publisher: Springer Science & Business Media
ISBN: 1597452084
Category : Medical
Languages : en
Pages : 359
Get Book Here
Book Description
These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.
