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Author: John Grisham
Publisher: Focused Ultrasound Foundation
ISBN: 1495179419
Category : Medical
Languages : en
Pages : 66
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Book Description
John Grisham says THE TUMOR is the most important book he has ever written. In this short book, he provides readers with a fictional account of how a real, new medical technology could revolutionize the future of medicine by curing with sound. THE TUMOR follows the present day experience of the fictional patient Paul, an otherwise healthy 35-year-old father who is diagnosed with a malignant brain tumor. Grisham takes readers through a detailed account of Paul’s treatment and his family’s experience that doesn’t end as we would hope. Grisham then explores an alternate future, where Paul is diagnosed with the same brain tumor at the same age, but in the year 2025, when a treatment called focused ultrasound is able to extend his life expectancy. Focused ultrasound has the potential to treat not just brain tumors, but many other disorders, including Parkinson’s, Alzheimer’s, hypertension, and prostate, breast and pancreatic cancer. For more information or to order a free hardcopy of the book, please visit The Focused Ultrasound Foundation’s website www.fusfoundation.org. Here you will find a video of Grisham on the TEDx stage with the Foundation’s chairman and a Parkinson’s patient who brings the audience to its feet sharing her incredible story of a focused ultrasound “miracle.” Readers will get a taste of the narrative they expect from Grisham, but this short book will also educate and inspire people to be hopeful about the future of medical innovation.
Author: John Grisham
Publisher: Focused Ultrasound Foundation
ISBN: 1495179419
Category : Medical
Languages : en
Pages : 66
Get Book Here
Book Description
John Grisham says THE TUMOR is the most important book he has ever written. In this short book, he provides readers with a fictional account of how a real, new medical technology could revolutionize the future of medicine by curing with sound. THE TUMOR follows the present day experience of the fictional patient Paul, an otherwise healthy 35-year-old father who is diagnosed with a malignant brain tumor. Grisham takes readers through a detailed account of Paul’s treatment and his family’s experience that doesn’t end as we would hope. Grisham then explores an alternate future, where Paul is diagnosed with the same brain tumor at the same age, but in the year 2025, when a treatment called focused ultrasound is able to extend his life expectancy. Focused ultrasound has the potential to treat not just brain tumors, but many other disorders, including Parkinson’s, Alzheimer’s, hypertension, and prostate, breast and pancreatic cancer. For more information or to order a free hardcopy of the book, please visit The Focused Ultrasound Foundation’s website www.fusfoundation.org. Here you will find a video of Grisham on the TEDx stage with the Foundation’s chairman and a Parkinson’s patient who brings the audience to its feet sharing her incredible story of a focused ultrasound “miracle.” Readers will get a taste of the narrative they expect from Grisham, but this short book will also educate and inspire people to be hopeful about the future of medical innovation.
Author: Patrick Peiyong Ye
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Ultrasound neuromodulation has recently gained attention as a novel brain stimulation technology. There are several obstacles that ultrasound neuromodulation faces before the technology is ready for clinical use, including the need for optimizing ultrasound parameters, understanding of the unknown mechanism, and characterizing potential stimulation confounds. In this dissertation, I will present research addressing several of these challenges. I investigated the frequency dependence of ultrasound neuromodulation in the mouse model, with results suggesting an inherent tradeoff between spatial focusing and stimulation efficacy. In collaboration with the Baccus lab, we found evidence supporting a radiation force hypothesis for the mechanism of neuromodulation. Finally, I hypothesized that ultrasound was causing stimulation confounds via either the vestibular system or the tactile sensory system. Experiments using a vestibulotoxin mouse model suggest that stimulation of the vestibular system may play a significant role in ultrasound-elicited motor responses. Future work is still needed to address questions regarding optimal parameters, the mechanism, and stimulation confounds as ultrasound neuromodulation techniques mature.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309376211
Category : Medical
Languages : en
Pages : 103
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Book Description
Based on advances in biotechnology and neuroscience, non-invasive neuromodulation devices are poised to gain clinical importance in the coming years and to be of increasing interest to patients, clinicians,health systems, payers, and industry. Evidence suggests that both therapeutic and non-therapeutic applications of non-invasive neuromodulation will continue to expand in coming years, particularly for indications where treatments are currently insufficient, such as drug-resistant depression. Given the growing interest in non-invasive neuromodulation technologies, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders convened a workshop, inviting a range of stakeholders - including developers of devices and new technologies, researchers, clinicians, ethicists, regulators, and payers - to explore the opportunities, challenges, and ethical questions surrounding the development, regulation, and reimbursement of these devices for the treatment of nervous system disorders as well as for non-therapeutic uses, including cognitive and functional enhancement. This report highlights the presentation and discussion of the workshop.
Author: Ferenc A. Jolesz
Publisher: CRC Press
ISBN: 1420019937
Category : Medical
Languages : en
Pages : 217
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Book Description
MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr
Author: Stephen Alexander Lee
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Based on the findings presented herein, noninvasive FUS peripheral stimulation has the potential for radically shifting the traditional pharmaceutical paradigms in chronic and acute pain treatment by altering signals before being processed in the spinal cord and ultimately the brain. The studies outlined herein serve to elucidate mechanisms of FUS in the PNS, as well as provide the starting foundations for further development of FUS as an effective pain treatment.
Author: Clement Hamani
Publisher: John Wiley & Sons
ISBN: 1118801040
Category : Medical
Languages : en
Pages : 518
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Book Description
Edited by an expert multidisciplinary team, Neuromodulation in Psychiatry is the first reference guide to address both invasive and non-invasive neuromodulation strategies used in psychiatry. Covers basic principles, technical aspects, clinical applications and ethical considerations Presents up-to-date evidence in comprehensive summaries suitable for all levels of experience Each technique is clearly explained along with its implications for real-world clinical practice Allows psychiatrists to make informed decisions regarding neuromodulation for their patients
Author: Jean-Michel Escoffre
Publisher: Springer
ISBN: 3319225367
Category : Medical
Languages : en
Pages : 459
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Book Description
This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.
Author: Tiago da Silva Freitas
Publisher: Springer Nature
ISBN: 3030847780
Category : Medical
Languages : en
Pages : 320
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Book Description
Neuromodulation implants are currently one of the most successful techniques in the treatment of chronic pain, a condition that affects more and more patients each year, leading to reduced quality of life as well as economic losses. Neuromodulation implants for pain are a relatively new technique and are being increasingly used around the globe. However, technical training is not available for every implanter as there are relatively few centers in the world. Further, refresher courses for low-rate implanters are not available. This book fills that gap by offering an update on the best techniques currently used, providing a step-by-step guide on how to perform these procedures correctly. Based on the experiences of leading physicians in the field, it also discusses how to manage both major and minor complications. Lastly, it covers the neuromodulatory intervention techniques used to treat chronic pain in various clinical areas. As such it is a valuable resource for pain physicians as well as neurosurgeons, orthopedists and anesthetists.
Author: Edin Mehić
Publisher:
ISBN:
Category :
Languages : en
Pages : 43
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Book Description
Transcranial ultrasound can alter brain function transiently and nondestructively, offering a new tool to study brain function now and to inform future therapies. Previous research on neuromodulation implemented pulsed low-frequency ultrasound with spatial peak temporal average intensities (ISPTA) of 0.1-10 W/cm2. That work used transducers that either insonified relatively large volumes of mouse brain (several mL) with relatively low-frequency ultrasound and produced bilateral motor responses, or relatively small volumes of brain (on the order of 0.06 mL) with relatively high-frequency ultrasound that produced unilateral motor responses. However, these previous studies have no modality for explaining how the ultrasound causes activation in the brain, and furthermore their ultrasound protocols do not allow for the precise activation that is required for the proper study of neuromodulation. This study seeks to increase anatomical specificity to neuromodulation with modulated focused ultrasound (mFU) as well as to provide an explanation for how the stimulation occurs biologically. We hypothesize that we can induce focal, central and associated peripheral activity in the motor cortex of primates using mFU in a manner comparable to electrical stimulation and capable of direct measurement by ECoG because we believe that neuromodulatory ultrasound stimulation of the brain excites neural circuits by depolarizing cells through the motor deformation of ion channels. Here, 'modulated' means modifying a focused 2-MHz carrier signal dynamically with a 500-kHz signal as in vibro-acoustography, thereby creating a low-frequency but small volume source of neuromodulation. We have shown that application of transcranial mFU to lightly anesthetized mice produces various motor movements with high spatial selectivity (on the order of 1 mm) that scales with the temporal average ultrasound intensity. Alone, mFU and focused ultrasound (FUS) each induce motor activity, including unilateral motions, though anatomical location and type of motion varied. We then moved to a primate model to determine the relative efficacy of mFU compared to electrical stimulation. Furthermore, our studies aimed to determine the biophysical processes through which they act. Currently, it is difficult to record neural activity after electric stimulation in the first few milliseconds after action potential onset due to various electrical problems. We have shown in vitro that with focused ultrasound, these problems can be bypassed. We explored the effects of this ultrasound applied to the brain by observing the resulting electrical activity induced through mechanical stimulation. We monitored neural excitation within our best approximation of the motor strip. Also of interest has been exploration of the potential research and clinical applications for targeted, transcranial neuromodulation created by modulated focused ultrasound, especially mFU's ability to produce compact sources of ultrasound at the very low frequencies (10-100s of Hertz) that correlate to the natural frequencies of the brain.
Author: Jeffrey Arle
Publisher: Academic Press
ISBN: 0128005963
Category : Medical
Languages : en
Pages : 342
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Book Description
Innovative Neuromodulation serves as an extensive reference that includes a basic introduction to the relevant aspects of clinical neuromodulation that is followed by an in-depth discussion of the innovative surgical and therapeutic applications that currently exist or are in development. This information is critical for neurosurgeons, neurophysiologists, bioengineers, and other proceduralists, providing a clear presentation of the frontiers of this exciting and medically important area of physiology. As neuromodulation remains an exciting and rapidly advancing field—appealing to many disciplines—the editors' initial work (Essential Neuromodulation, 2011) is well complemented by this companion volume. - Presents a comprehensive reference on the emerging field of neuromodulation that features chapters from leading physicians and researchers in the field - Provides commentary for perspectives on different technologies and interventions to heal and improve neurological deficits - Contains 300 full-color pages that begin with an overview of the clinical phases involved in neuromodulation, the challenges facing therapies and intraoperative procedures, and innovative solutions for better patient care
